Advancing Mandibular Reconstruction for Ameloblastoma: A Literature Review on the Role of Virtual Surgical Planning and Custom 3D Implants
DOI:
10.29303/jppipa.v11i12.11069Published:
2025-12-31Downloads
Abstract
Ameloblastoma is a benign yet locally aggressive odontogenic tumor often requiring extensive mandibular resection, leading to significant anatomical and functional deficits. Traditional reconstruction techniques frequently fall short in restoring facial symmetry, occlusal function, and aesthetic outcomes. Virtual surgical planning (VSP) has revolutionized mandibular reconstruction by enabling digitally guided, patient-specific workflows. This literature review evaluates the integration of VSP in managing ameloblastoma-related mandibular defects, particularly with custom titanium implants, lattice structures, and artificial intelligence. Evidence suggests that VSP enhances surgical precision, shortens operative time, and improves aesthetic and functional outcomes. The convergence of virtual planning, additive manufacturing, and AI underscores VSP's emerging status as the gold standard in maxillofacial oncologic surgery.
Keywords:
3D printing Ameloblastoma Artificial intelligence Custom implants Mandibular reconstruction Virtual surgical planningReferences
Antony, A. K., Chen, W. F., Kolokythas, A., Weimer, K. A., & Cohen, M. N. (2011). Use of virtual surgery and stereolithography-guided osteotomy for mandibular reconstruction with the free fibula. Plastic and Reconstructive Surgery, 128(5), 1080–1084. https://doi.org/10.1097/PRS.0b013e31822b6723 DOI: https://doi.org/10.1097/PRS.0b013e31822b6723
Ardila, C. M., Hernández-Arenas, Y., & Álvarez-Martínez, E. (2022). Mandibular Body Reconstruction Utilizing a Three-Dimensional Custom-Made Porous Titanium Plate: A Four-Year Follow-Up Clinical Report. Case Reports in Dentistry, 2022. https://doi.org/10.1155/2022/5702066 DOI: https://doi.org/10.1155/2022/5702066
Chakraborty, S., Guha, R. P., Naskar, S., & Banerjee, R. (2022). Custom-Made 3D Titanium Plate for Mandibular Reconstruction in Surgery of Ameloblastoma: A Novel Case Report. Surgical Techniques Development, 11(3), 98–104. https://doi.org/10.3390/std11030009 DOI: https://doi.org/10.3390/std11030009
Ciocca, L., Mazzoni, S., Fantini, M., Persiani, F., Baldissara, P., Marchetti, C., & Scotti, R. (2012). A CAD/CAM-prototyped anatomical condylar prosthesis connected to a custom-made bone plate to support a fibula free flap. Medical and Biological Engineering and Computing, 50(7), 743–749. https://doi.org/10.1007/s11517-012-0898-4 DOI: https://doi.org/10.1007/s11517-012-0898-4
Cortese, A., Spirito, F., Claudio, P. P., Lo Muzio, L., Ruggiero, A., & Gargiulo, M. (2023). Mandibular Reconstruction after Resection of Ameloblastoma by Custom-Made CAD/CAM Mandibular Titanium Prosthesis: Two Case Reports, Finite Element Analysis and Discussion of the Technique. Dentistry Journal, 11(4). https://doi.org/10.3390/dj11040106 DOI: https://doi.org/10.3390/dj11040106
Du, R., Su, Y. X., Yan, Y., Choi, W. S., Yang, W. F., Zhang, C., Chen, X., Curtin, J. P., Ouyang, J., & Zhang, B. (2020). A Systematic Approach for Making 3D-Printed Patient-Specific Implants for Craniomaxillofacial Reconstruction. Engineering, 6(11), 1291–1301. https://doi.org/10.1016/j.eng.2020.02.019 DOI: https://doi.org/10.1016/j.eng.2020.02.019
Hazm, O. B., Nadhum, N. S., & Shaheed, A. M. (2024). Mandible Reconstruction with 3D Printed Models. Dentistry 3000, 12(1). https://doi.org/10.5195/d3000.2024.538 DOI: https://doi.org/10.5195/d3000.2024.538
Hijazi, K. M., Dixon, S. J., Armstrong, J. E., & Rizkalla, A. S. (2024). Titanium Alloy Implants with Lattice Structures for Mandibular Reconstruction. In Materials (Vol. 17, Issue 1). Multidisciplinary Digital Publishing Institute (MDPI). https://doi.org/10.3390/ma17010140 DOI: https://doi.org/10.3390/ma17010140
Hirsch, D. L., Garfein, E. S., Christensen, A. M., Weimer, K. A., Saddeh, P. B., & Levine, J. P. (2009). Use of Computer-Aided Design and Computer-Aided Manufacturing to Produce Orthognathically Ideal Surgical Outcomes: A Paradigm Shift in Head and Neck Reconstruction. Journal of Oral and Maxillofacial Surgery, 67(10), 2115–2122. https://doi.org/10.1016/j.joms.2009.02.007 DOI: https://doi.org/10.1016/j.joms.2009.02.007
Mongan, J., Moy, L., & Kahn, C. E. (2020). Checklist for Artificial Intelligence in Medical Imaging (CLAIM): A Guide for Authors and Reviewers. In Radiology: Artificial Intelligence (Vol. 2, Issue 2). Radiological Society of North America Inc. https://doi.org/10.1148/ryai.2020200029 DOI: https://doi.org/10.1148/ryai.2020200029
Moro, A., Pelo, S., Gasparini, G., Saponaro, G., Todaro, M., Pisano, G., D’Amato, G., & Doneddu, P. (2020). Virtual Surgical Planning for Reconstruction of Giant Ameloblastoma of the Mandible. Annals of Plastic Surgery, 85(1), 43–49. https://doi.org/10.1097/SAP.0000000000002390 DOI: https://doi.org/10.1097/SAP.0000000000002390
Murr, L. E., Gaytan, S. M., Medina, F., Lopez, H., Martinez, E., MacHado, B. I., Hernandez, D. H., Martinez, L., Lopez, M. I., Wicker, R. B., & Bracke, J. (2010). Next-generation biomedical implants using additive manufacturing of complex cellular and functional mesh arrays. Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences, 368(1917), 1999–2032. https://doi.org/10.1098/rsta.2010.0010 DOI: https://doi.org/10.1098/rsta.2010.0010
Pankert, T., Lee, H., Peters, F., Hölzle, F., Modabber, A., & Raith, S. (2023). Mandible segmentation from CT data for virtual surgical planning using an augmented two-stepped convolutional neural network. International Journal of Computer Assisted Radiology and Surgery, 18(8), 1479–1488. https://doi.org/10.1007/s11548-022-02830-w DOI: https://doi.org/10.1007/s11548-022-02830-w
Park, S., Kim, H., Shim, E., Hwang, B. Y., Kim, Y., Lee, J. W., & Seo, H. (2022). Deep Learning-Based Automatic Segmentation of Mandible and Maxilla in Multi-Center CT Images. Applied Sciences (Switzerland), 12(3). https://doi.org/10.3390/app12031358 DOI: https://doi.org/10.3390/app12031358
Probst, F. A., Liokatis, P., Mast, G., & Ehrenfeld, M. (2023). Virtual planning for mandible resection and reconstruction. In Innovative Surgical Sciences (Vol. 8, Issue 3, pp. 137–148). Walter de Gruyter GmbH. https://doi.org/10.1515/iss-2021-0045 DOI: https://doi.org/10.1515/iss-2021-0045
Reichart, P. A., Philipsen, H. P., & Sonner, S. (1995). Ameloblastoma: Biological Profile of 3677 Cases. In Eur ’j Cancer (Vol. 31, Issue 2). DOI: https://doi.org/10.1016/0964-1955(94)00037-5
Roser, S. M., Ramachandra, S., Blair, H., Grist, W., Carlson, G. W., Christensen, A. M., Weimer, K. A., & Steed, M. B. (2010). The accuracy of virtual surgical planning in free fibula mandibular reconstruction: Comparison of planned and final results. Journal of Oral and Maxillofacial Surgery, 68(11), 2824–2832. https://doi.org/10.1016/j.joms.2010.06.177 DOI: https://doi.org/10.1016/j.joms.2010.06.177
Rustemeyer, J., Melenberg, A., & Sari-Rieger, A. (2014). Costs incurred by applying computer-aided design/computer-aided manufacturing techniques for the reconstruction of maxillofacial defects. Journal of Cranio-Maxillofacial Surgery, 42(8), 2049–2055. https://doi.org/10.1016/j.jcms.2014.09.014 DOI: https://doi.org/10.1016/j.jcms.2014.09.014
Ryan, G., Pandit, A., & Apatsidis, D. P. (2006). Fabrication methods of porous metals for use in orthopaedic applications. In Biomaterials (Vol. 27, Issue 13, pp. 2651–2670). https://doi.org/10.1016/j.biomaterials.2005.12.002 DOI: https://doi.org/10.1016/j.biomaterials.2005.12.002
Semerci, Z. M., & Yardımcı, S. (2024). Empowering Modern Dentistry: The Impact of Artificial Intelligence on Patient Care and Clinical Decision Making. In Diagnostics (Vol. 14, Issue 12). Multidisciplinary Digital Publishing Institute (MDPI). https://doi.org/10.3390/diagnostics14121260 DOI: https://doi.org/10.3390/diagnostics14121260
Shaheen, E., Sun, Y., Jacobs, R., & Politis, C. (2017). Three-dimensional printed final occlusal splint for orthognathic surgery: design and validation. International Journal of Oral and Maxillofacial Surgery, 46(1), 67–71. https://doi.org/10.1016/j.ijom.2016.10.002 DOI: https://doi.org/10.1016/j.ijom.2016.10.002
Sharaf, B., Levine, J. P., Hirsch, D. L., Bastidas, J. A., Schiff, B. A., & Garfein, E. S. (2010). Importance of computer-aided design and manufacturing technology in the multidisciplinary approach to head and neck reconstruction. Journal of Craniofacial Surgery, 21(4), 1277–1280. https://doi.org/10.1097/SCS.0b013e3181e1b5d8 DOI: https://doi.org/10.1097/SCS.0b013e3181e1b5d8
Shin, D. H., Kim, H. J., Oh, J. S., & Moon, S. Y. (2025). Enhancing Mandibular Reconstruction with Surgeon–Bioengineer Collaboration: A Protocol for Virtual Surgical Planning. Applied Sciences (Switzerland), 15(2). https://doi.org/10.3390/app15020687 DOI: https://doi.org/10.3390/app15020687
Succo, G., Berrone, M., Battiston, B., Tos, P., Goia, F., Appendino, P., & Crosetti, E. (2015). Step-by-step surgical technique for mandibular reconstruction with fibular free flap: Application of digital technology in virtual surgical planning. European Archives of Oto-Rhino-Laryngology, 272(6), 1491–1501. https://doi.org/10.1007/s00405-014-3078-3 DOI: https://doi.org/10.1007/s00405-014-3078-3
Tarsitano, A., Battaglia, S., Ricotta, F., Bortolani, B., Cercenelli, L., Marcelli, E., Cipriani, R., & Marchetti, C. (2018). Accuracy of CAD/CAM mandibular reconstruction: A three-dimensional, fully virtual outcome evaluation method. Journal of Cranio-Maxillofacial Surgery, 46(7), 1121–1125. https://doi.org/10.1016/j.jcms.2018.05.010 DOI: https://doi.org/10.1016/j.jcms.2018.05.010
Tarsitano, A., Del Corso, G., Ciocca, L., Scotti, R., & Marchetti, C. (2015). Mandibular reconstructions using computer-aided design/computer-aided manufacturing: A systematic review of a defect-based reconstructive algorithm. Journal of Cranio-Maxillofacial Surgery, 43(9), 1785–1791. https://doi.org/10.1016/j.jcms.2015.08.006 DOI: https://doi.org/10.1016/j.jcms.2015.08.006
Tarsitano, A., Mazzoni, S., Cipriani, R., Scotti, R., Marchetti, C., & Ciocca, L. (2014). The CAD-CAM technique for mandibular reconstruction: An 18 patients oncological case-series. Journal of Cranio-Maxillofacial Surgery, 42(7), 1460–1464. https://doi.org/10.1016/j.jcms.2014.04.011 DOI: https://doi.org/10.1016/j.jcms.2014.04.011
van Baar, G. J. C., Forouzanfar, T., Liberton, N. P. T. J., Winters, H. A. H., & Leusink, F. K. J. (2018). Accuracy of computer-assisted surgery in mandibular reconstruction: A systematic review. In Oral Oncology (Vol. 84, pp. 52–60). Elsevier Ltd. https://doi.org/10.1016/j.oraloncology.2018.07.004 DOI: https://doi.org/10.1016/j.oraloncology.2018.07.004
Wilde, F., Hanken, H., Probst, F., Schramm, A., Heiland, M., & Cornelius, C. P. (2015). Multicenter study on the use of patient-specific CAD/CAM reconstruction plates for mandibular reconstruction. International Journal of Computer Assisted Radiology and Surgery, 10(12), 2035–2051. https://doi.org/10.1007/s11548-015-1193-2 DOI: https://doi.org/10.1007/s11548-015-1193-2
Zhang, L., Liu, Z., Li, B., Yu, H., Shen, S. G., & Wang, X. (2016). Evaluation of computer-assisted mandibular reconstruction with vascularized fibular flap compared to conventional surgery. Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, 121(2), 139–148. https://doi.org/10.1016/j.oooo.2015.10.005 DOI: https://doi.org/10.1016/j.oooo.2015.10.005
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