Immune Response to Dengue Fever Infection in Endemic Areas of Lombok Barat
DOI:
10.29303/jppipa.v11i12.13163Published:
2025-12-25Downloads
Abstract
Dengue infection makes the body create immune responses, such as the formation of immunoglobulins. In Lombok Barat, 222 DHF cases with three fatalities are reported, with a CFR of 1.4%. The aim of this study was to determine the immune response to dengue fever in West Lombok. Analytical observational research method with cross-sectional study. Population included DHF patients in endemic areas of Lombok Barat, a total of 33 respondents suspected of dengue fever. Data on immune responses were gathered using dengue IgM and IgG tests. Respondent immune responses exhibited that 21.2% tested positive and 78.8% tested negative for IgM, while 63.6% tested positive and 36.4% tested negative for IgG. Statistical analysis of dengue fever infection with IgM using the Chi-square test obtained p = 0.049 <α = 0.05, while dengue fever infection with IgG was p = 0.113 > α = 0.05. The results of the analysis showed that there was a significant relationship between dengue fever infection and IgM test results, but there was no significant relationship between dengue fever infection and IgG test results. Most of the DHF infections in Lombok Barat were categorized as primary infections.
Keywords:
Dengue infection IgG IgM Immune responseReferences
Abdul, H. H. (2023). The Relationship between Mosquito Nest Eradication Behavior and the Habit of Using Mosquito Repellent Against Dengue Hemorrhagic Fever in Pekat Village, Sumbawa District, Sumbawa Regency. Jurnal Penelitian Pendidikan IPA, 9(1), 87–92. https://doi.org/10.29303/jppipa.v9i1.2035 DOI: https://doi.org/10.29303/jppipa.v9i1.2035
Arshad, S., Ahmed, M., Khan, F., Khurram, M., & Usman, B. (2021). Presenting Complaints in Acute Dengue Infection and Differences in Presenting Complaints between Primary and Secondary Dengue Infections. Cureus, 13(11), e19320. https://doi.org/10.7759/cureus.19320 DOI: https://doi.org/10.7759/cureus.19320
Arsyadin, A., Aqwam, A., Khairunissa, R., Endang, H. K., Rosita, R., & Fahrul, H. A. (2023). Dengue Hemorrhagic Fever in Bima City: A Study. Jurnal Penelitian Pendidikan IPA, 9(6), 4869–4879. https://doi.org/10.29303/jppipa.v9i6.4787 DOI: https://doi.org/10.29303/jppipa.v9iSpecialIssue.7236
Baitanu, J. Z., Masihin, L., Rustan, L. D., Siregar, D., & Aiba, S. (2022). Hubungan antara Usia, Jenis Kelamin, Mobilitas, dan Pengetahuan dengan Kejadian Demam Berdarah Dengue di Wulauan, Kabupaten Minahasa. MANUJU, 4(5), 1230-1241. https://doi.org/10.33024/mnj.v4i5.6348 DOI: https://doi.org/10.33024/mnj.v4i5.6348
Bhatia, S., Bansal, D., Patil, S., Pandya, S., Ilyas, Q. M., & Imran, S. (2022). A Retrospective Study of Climate Change Affecting Dengue: Evidences, Challenges and Future Directions. Frontiers in Public Health, 10(May), 1–16. https://doi.org/10.3389/fpubh.2022.884645 DOI: https://doi.org/10.3389/fpubh.2022.884645
Bhatt, S., Gething, P. W., Brady, O. J., Messina, J. P., Farlow, A. W., Moyes, C. L., … Hay, S. I. (2013). The Global Distribution and Burden of Dengue. Nature, 496(7446), 504–507. https://doi.org/10.1038/nature12060 DOI: https://doi.org/10.1038/nature12060
Burrell, C. J., Howard, C. R., & Murphy, F. A. (2017). Epidemiology of Viral Infections. In Fenner and White’s Medical Virology, pp. 185–203. https://doi.org/10.1016/B978-0-12-375156-0.00013-8 DOI: https://doi.org/10.1016/B978-0-12-375156-0.00013-8
Changal, K. H., Raina, A. H., Raina, A., Raina, M., Bashir, R., Latief, M., … Changal, Q. H. (2016). Differentiating Secondary from Primary Dengue Using IgG to IgM Ratio in Early Dengue: An Observational Hospital Based Clinico-Serological Study from North India. BMC Infectious Diseases, 16(1), 715. https://doi.org/10.1186/s12879-016-2053-6 DOI: https://doi.org/10.1186/s12879-016-2053-6
Chua, M. N., Luong, C. Q., Rusmil, K., Wirawan, D. N., Nallusamy, R., & Pitisuttithum, P. (2014). Clinical Efficacy and Safety of a Novel Tetravalent Dengue Vaccine in Healthy Children in Asia: A Phase 3, Randomised. The Lancet, 6736(14), 1–8. http://dx.doi.org/10.1016/S0140-6736(14)61060-6
Dikes Provinsi NTB. (2021). Jumlah Kasus Demam Berdarah Dangue (DBD) di Provinsi NTB Tahun 2021. Dikes Provinsi NTB. Retrieved from https://data.ntbprov.go.id/dataset/jumlah-kasus-demam-berdarah-dangue-dbd-di-provinsi-ntb
Dinas Kesehatan Lombok Barat. (2022). Profil Kesehatan Lombok Barat Tahun 2022.
Dwiyanthi, K. L., Setiani, O., & Adi, M. S. (2023). Spatial Analysis of Dengue Hemorrhagic Fever Incidents Distribution and Dengue Virus Detection in Tanjung Priok. Jurnal Penelitian Pendidikan IPA, 9(SpecialIssue), 815–821. https://doi.org/10.29303/jppipa.v9iSpecialIssue.5394 DOI: https://doi.org/10.29303/jppipa.v9iSpecialIssue.5394
Facchinelli, L., Badolo, A., & McCall, P. J. (2023). Biology and Behaviour of Aedes aegypti in the Human Environment: Opportunities for Vector Control of Arbovirus Transmission. Viruses, 15(3). https://doi.org/10.3390/v15030636 DOI: https://doi.org/10.3390/v15030636
Guzman, M. G., & Harris, E. (2015). Dengue. Lancet (London, England), 385(9966), 453–465. https://doi.org/10.1016/S0140-6736(14)60572-9 DOI: https://doi.org/10.1016/S0140-6736(14)60572-9
Kaligis, E. C., Ratag, B. T., & Langi, F. F. L. (2023). Analysis of Dengue Hemorrhagic Fever Surveillance Data (2012-2021) in Indonesia. Indonesian Journal of Public Health and Preventive Medicine, 2(1). https://doi.org/10.35790/ijphpm.v2i1.51398
Kemenkes RI. (2022). Profil Kesehatan Indonesia. Jakarta: Kementerian Kesehatan RI.
Kemenkes RI. (2023). Atasi Dengue, Kemenkes Kembangkan Dua Teknologi ini – Sehat Negeriku. Jakarta: Kementerian Kesehatan RI.
Khetarpal, N., & Khanna, I. (2016). Dengue Fever: Causes, Complications, and Vaccine Strategies. Journal of Immunology Research, 2016(3). https://doi.org/10.1155/2016/6803098 DOI: https://doi.org/10.1155/2016/6803098
Klein, S. L., & Flanagan, K. L. (2016). Perbedaan Jenis Kelamin dalam Respons Imun. Nature Reviews Immunology, 16(10), 626–638. https://doi.org/10.1038/nri.2016.90 DOI: https://doi.org/10.1038/nri.2016.90
Kusuma, S. S. (2025). Clinical Manisfestations and Complications of Dengue Infection in Children: Insights and Comparisons with Adult Cases. Cermin Dunia Kedokteran, 52(8), 6–9. https://doi.org/10.55175/cdk.v52i8.1518 DOI: https://doi.org/10.55175/cdk.v52i8.1518
Lambrechts, L., Scott, T. W., & Gubler, D. J. (2010). Consequences of the Expanding Global Distribution of Aedes albopictus for Dengue Virus Transmission. PLOS Neglected Tropical Diseases, 4(5), e646. https://doi.org/10.1371/journal.pntd.0000646 DOI: https://doi.org/10.1371/journal.pntd.0000646
Marvianto, D., Ratih, O. D., & Wijaya, K. F. N. (2023). Infeksi Dengue Sekunder: Patofisiologi, Diagnosis, dan Implikasi Klinis. Cermin Dunia Kedokteran, 50(2), 70–74. https://doi.org/10.55175/cdk.v50i2.518 DOI: https://doi.org/10.55175/cdk.v50i2.518
Misnawati, M., Yusriadi, Y., Astri, Z., Abbas, A., & Asbar, A. (2025). Exploring Teachers' Initial Perceptions of Corpus Linguistics and Their Readiness to Incorporate Corpora in Classroom Instruction: A Qualitative Analysis. The Qualitative Report, 30(1), 3024-3042. https://doi.org/10.46743/2160-3715/2025.6867 DOI: https://doi.org/10.46743/2160-3715/2025.6867
Nastiti, S. A., Ramadanintyas, K. N., & Marsanti, A. S. (2021). Factors Related to Incident Dengue Hemorrhagic Fever (DHF). Jurnal Kesehatan Prima, 15(2), 149–155. https://doi.org/10.32.807/jkp.v15i2.681 DOI: https://doi.org/10.32807/jkp.v15i2.681
Panggabean, M., Panggabean, Y. C., Siahaan, L., Sinambela, A. H., Sepala, I., & Siregar, S. (2025). The Relationship between House Environmental Condition and Mosquito Larvae Density (Diptera: Culicidae) in Medan Denai Sub-District, Medan City. Jurnal Penelitian Pendidikan IPA, 11(7), 1066–1074. https://doi.org/10.29303/jppipa.v11i7.11076 DOI: https://doi.org/10.29303/jppipa.v11i7.11076
Purba, I. E., Nababan, D., & Kaban, E. S. (2023). Risk Factors of Dengue Hemorrhagic Fever. Jurnal Penelitian Pendidikan IPA, 9(10), 8131–8139. https://doi.org/10.29303/jppipa.v9i10.4882 DOI: https://doi.org/10.29303/jppipa.v9i10.4882
Puspita, D., & Aryati, A. (2018). SD Dengue Duo® (NS1, IgG, IgM) Rapid Test dalam Menunjang Diagnosis Infeksi Virus Dengue. Indonesian Journal of Clinical Pathology and Medical Laboratory, 16(2), 97. https://doi.org/10.24293/ijcpml.v16i2.980 DOI: https://doi.org/10.24293/ijcpml.v16i2.980
Rahmah, A., Sary, L., Perdana, A. A., & Sary, L. (2023). Prevention Behavior of Dengue Hemorrhagic Fever in Community Leaders in the Work Area of the Hajimena Health Center, South lampung Regency. Jurnal Penelitian Pendidikan IPA, 9(7), 5346–5352. https://doi.org/10.29303/jppipa.v9i7.3741 DOI: https://doi.org/10.29303/jppipa.v9i7.3741
Sabrina, P. I. (2024). Profil Penderita DBD pada Anak di Rumah Sakit Umum Karsa Husada Batu Tahun 2021-2023 (Undergraduate Thesis). Universitas Islam Negeri Maulana Malik Ibrahim. Retrieved from http://etheses.uin-malang.ac.id/71712/1/210701110010.pdf
Schaefer, T. J., Panda, P. K., & Wolford, R. W. (2023). Dengue Fever. Treasure Island (FL).
Sim, S., & Dimopoulos, G. (2010). Dengue Virus Inhibits Immune Responses in Aedes aegypti Cells. PLOS ONE, 5(5), e10678. https://doi.org/10.1371/journal.pone.0010678 DOI: https://doi.org/10.1371/journal.pone.0010678
Sukmawathi, N., Sawitri, A., & Megawati, I. (2024). Implementation of the Dengue Fever Surveillance System at the Klungkung District Health Office. Journal La Medihealtico, 5(1), 1134–1144. https://doi.org/10.37899/journallamedihealtico.v5i5.1685 DOI: https://doi.org/10.37899/journallamedihealtico.v5i5.1685
Sukohar, A. (2014). Demam Berdarah Dengue (DBD). Medula, 2(2), 1–15. Retrieved from https://media.neliti.com/media/publications/152633-ID-demam-berdarah-dengue-dbd.pdf
Tatontos, E. Y., Fihiruddin, F., & Inayati, N. (2021). Accurate Detection of Viral Serotipe Dengue Hemorrhagic Fever Through Aedes Sp Mosquitos Using Reverse Transcriptase Polymerase Chain Reaction (RT-PCR). Jurnal Riset Kesehatan, 10(2 SE-Articles), 148–152. https://doi.org/10.31983/jrk.v10i2.7706 DOI: https://doi.org/10.31983/jrk.v10i2.7706
Tatontos, E. Y., Getas, I. W., & Urip, U. (2022). Effectiveness of the Combination of Lethal Ovitrap Attractant of Local Organic Materials and Natural Larvicides in Dengue Hemorrhagic Fever Endemic Areas. Jurnal Penelitian Pendidikan IPA, 8(6), 2961–2968. https://doi.org/10.29303/jppipa.v8i6.2448 DOI: https://doi.org/10.29303/jppipa.v8i6.2448
Trisnadewi, N. N. L., & Wande, I. N. (2016). Demam Berdarah Dengue (DBD), Pemeriksaan Serologi, Infeksi Primer, Infeksi Sekunder. E-Jurnal Medika Udayana, 5(8). Retrieved from https://ojs.unud.ac.id/index.php/eum/article/view/22872
Urip, U., Rizki, K., Tatontos, E. Y., Gunarti, G., & Kholik, K. (2023). The Density of Aedes aegypti Larvae Density and the Incidence of Dengue Hemorrhagic Fever in the Pesingahan Environment, Pagesangan Barat Village, Mataram. Info Kesehatan, 21(1). https://doi.org/10.31965/infokes.vol21iss1.986 DOI: https://doi.org/10.31965/infokes.Vol21.Iss1.986
Utama, I. M. S., Lukman, N., Sukmawati, D. D., Alisjahbana, B., Alam, A., Murniati, D., … Parwati, K. T. M. (2019). Dengue Viral Infection in Indonesia: Epidemiology, Diagnostic Challenges, and Mutations from an Observational Cohort Study. PLOS Neglected Tropical Diseases, 13(10), e0007785. https://doi.org/10.1371/journal.pntd.0007785 DOI: https://doi.org/10.1371/journal.pntd.0007785
Waggoner, J. J. (2016). Clinical Presentation in Nicaraguan with Zika Virus, Chikunguna Virus, and Dengue Virus. Clinical Infectious Diseases, 63, 1584-1590. https://doi.org/10.1093/cid/ciw589 DOI: https://doi.org/10.1093/cid/ciw589
Wang, W. H., Lin, C. Y., Chang, K., Urbina, A. N., Assavalapsakul, W., Thitithanyanont, A., … Wang, S. F. (2019). A Clinical and Epidemiological Survey of the Largest Dengue Outbreak in Southern Taiwan in 2015. International Journal of Infectious Diseases, 88, 88–99. https://doi.org/10.1016/j.ijid.2019.09.007 DOI: https://doi.org/10.1016/j.ijid.2019.09.007
Wang, W. H., Urbina, A. N., Chang, M. R., Assavalapsakul, W., Lu, P. L., Chen, Y. H., & Wang, S. F. (2020). Dengue Hemorrhagic Fever – A Systemic Literature Review of Current Perspectives on Pathogenesis, Prevention and Control. Journal of Microbiology, Immunology and Infection, 53(6), 963–978. https://doi.org/10.1016/j.jmii.2020.03.007 DOI: https://doi.org/10.1016/j.jmii.2020.03.007
WHO. (2009). DHF Guidelines for Diagnosis, Treatment, Prevention and Control. WHO. https://doi.org/10.1176/pn.41.1.0029b
WHO. (2011). Comprehensive Guidelines for Prevention and Control of Dengue and Dengue Haemorrhagic Fever. In WHO Regional Publication SEARO. https://doi.org/10.1017/CBO9781107415324.004
WHO. (2018). Integrated Management Strategy for Dengue Prevention and Control in the Region of the Americas. WHO.
WHO. (2023). Dengue- Global situation. Retrieved from https://www.who.int/emergencies/disease-outbreak-news/item/2023-DON498
Wila, R. W., & Nusa, R. (2020). Gambaran Klinis dan Respon Imun Penderita Demam Berdarah Dengue di Rumah Sakit Kristen Lindi Mara Sumba Timur Selama Bulan Januari Sampai dengan Desember 2018. Balaba: Jurnal Litbang Pengendalian Penyakit Bersumber Binatang Banjarnegara, 16(2), 209–216. https://doi.org/10.22435/blb.v16i2.2816 DOI: https://doi.org/10.22435/blb.v16i2.2816
Yandika, A. (2022). Hubungan antara Tingkat Pendidikan dan Tingkat Pengetahuan Masyarakat Terhadap Kejadian Demam Berdarah. Cerdika: Jurnal Ilmiah Indonesia, 2(10), 874–882. https://doi.org/10.59141/cerdika.v2i10.458 DOI: https://doi.org/10.59141/cerdika.v2i10.458
Yung, C. F., Lee, K. S., Thein, T. L., Tan, L. K., Gan, V. C., Wong, J. G. X., … Leo, Y. S. (2015). Dengue Serotype-Specific Differences in Clinical Manifestation, Laboratory Parameters and Risk of Severe Disease in Adults, Singapore. American Journal of Tropical Medicine and Hygiene, 92(5), 999–1005. https://doi.org/10.4269/ajtmh.14-0628 DOI: https://doi.org/10.4269/ajtmh.14-0628
Yuniar, V. T., Raharjo, M., Martini, M., & Nurjazuli, N. (2024). Hubungan Pengetahuan dengan Kejadian Demam Berdarah Dengue di Kota Lubuklinggau Sumatera Selatan. Jurnal Kesehatan Lingkungan Indonesia, 23(2), 234-240. https://doi.org/10.14710/jkli.23.2.234-240 DOI: https://doi.org/10.14710/jkli.23.2.234-240
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