Vol. 11 No. 11 (2025): November
Open Access
Peer Reviewed

Microplastic and Nanoplastic Pollution in Pregnant Women: Contribution to Preterm Birth and Health Policy Implications

Authors

Arga Setyo Adji , Alan Dharmasaputra , Florencia Audrey , Grace Eka Wijayanti , Luh Putu Diah Ayuning , Bambang Edi Suwito , Angela Puspita

DOI:

10.29303/jppipa.v11i11.13225

Published:

2025-11-25

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Abstract

Microplastic and nanoplastic pollution has emerged as a major environmental and public health issue, particularly in developing countries such as Indonesia, where contamination levels are among the highest in the world. Recent findings from Ekspedisi Sungai Nusantara (2022) revealed microplastic concentrations of up to 636 particles per liter in East Java’s rivers, indicating widespread exposure through water, air, and food sources. Indonesia also ranks third globally in plastic pollution, contributing approximately 3.4 million tons annually. This study employs a literature review and policy analysis approach to assess the impact of microplastic exposure on maternal and fetal health, with an emphasis on preterm birth risk and the adequacy of current regulatory frameworks. Evidence from human and animal studies indicates that microplastics can translocate across the placental barrier, inducing oxidative stress, inflammation, and endocrine disruption that may impair fetal development and increase the risk of preterm birth. Despite the implementation of the Regulation of the Minister of Health of the Republic of Indonesia No. 2 of 2025 concerning reproductive health, the absence of explicit environmental pollutant protection clauses highlights a critical policy gap. Strengthening intersectoral collaboration among the Ministry of Environment, the Ministry of Health, and the Ministry of Marine Affairs and Fisheries is essential to establish national safety thresholds, implement continuous monitoring, and integrate reproductive health protections into environmental policies. This study underscores the urgent need for comprehensive microplastic management strategies and maternal health safeguards to mitigate the growing risks associated with microplastic and nanoplastic exposure in Indonesia.

Keywords:

Environmental policy Maternal health Microplastics Nano-plastics Placental exposure Preterm birth

References

Adji, A. S. (2024). Analysis of Ministry of Health Regulation No. 30 of 2022 on Hospital Service Quality in Indonesia. ARRUS Journal of Social Sciences and Humanities, 4(3), 310. https://doi.org/10.35877/soshum2582 DOI: https://doi.org/10.35877/soshum2582

Alijagic, A., Hedbrant, A., Persson, A., Larsson, M., Engwall, M., & Särndahl, E. (2023). NLRP3 inflammasome as a sensor of micro-and nanoplastics immunotoxicity. Frontiers in Immunology, 14, 1178434. https://doi.org/10.3389/fimmu.2023.1178434 DOI: https://doi.org/10.3389/fimmu.2023.1178434

Amereh, F., Amjadi, N., Mohseni-Bandpei, A., Isazadeh, S., Mehrabi, Y., Eslami, A., Naeiji, Z., & Rafiee, M. (2022). Placental Plastics in Young Women From General Population Correlate With Reduced Foetal Growth in Iugr Pregnancies. Environmental Pollution (Barking, Essex : 1987). https://doi.org/10.1016/J.ENVPOL.2022.120174 DOI: https://doi.org/10.1016/j.envpol.2022.120174

Anifowoshe, A. T., Akhtar, M. N., Majeed, A., Singh, A. S., Ismail, T. F., & Nongthomba, U. (2025). Microplastics: A threat to Fetoplacental unit and Reproductive systems. Toxicology Reports, 101938. https://doi.org/10.1016/j.toxrep.2025.101938 DOI: https://doi.org/10.1016/j.toxrep.2025.101938

Bai, J., Chen, M., Xu, W., Zhou, F., Tang, J., Liu, X., Li, H., Wang, Y., & Zhang, H. (2024). Microplastics cause embryonic growth retardation and placental dysfunction via ER stress and apoptosis. Toxicology, 500, 153612. https://doi.org/10.1016/j.tox.2024.153612

Braun, T., Ehrlich, L., Henrich, W., Koeppel, S., Lomako, I., Schwabl, P., & Liebmann, B. (2021). Detection of Microplastic in Human Placenta and Meconium in a Clinical Setting. Pharmaceutics, 13(7). https://doi.org/10.3390/PHARMACEUTICS13070921 DOI: https://doi.org/10.3390/pharmaceutics13070921

Cai, Y., Li, C., Zhao, Y. A., Banni, M., Tchounwou, P. B., Cai, Y., Li, C., & Zhao, Y. (2021). A Review of the Migration and Transformation of Microplastics in Inland Water Systems. International Journal of Environmental Research and Public Health, 19(1), 148. https://doi.org/10.3390/IJERPH19010148 DOI: https://doi.org/10.3390/ijerph19010148

Choi, M., Park, S., & Kim, Y. (2025). Microplastics and human health: unraveling the toxicological mechanisms and exposure routes. Environmental Research, 242, 118237. https://doi.org/10.1016/j.envres.2025.118237

Dibbon, K. C., Mercer, G. V, Maekawa, A. S., Hanrahan, J., Steeves, K. L., Ringer, L. C. M., Simpson, A. J., Simpson, M. J., Baschat, A. A., Kingdom, J. C., & others. (2024). Polystyrene micro-and nanoplastics cause placental dysfunction in mice. Biology of Reproduction, 110(1), 211–218. https://doi.org/10.1093/biolre/ioad126 DOI: https://doi.org/10.1093/biolre/ioad126

Elizalde-Velázquez, G. A., & Gómez-Oliván, L. M. (2021). Microplastics in Aquatic Environments: A Review on Occurrence, Distribution, Toxic Effects, and Implications for Human Health. Science of The Total Environment, 780, 146551. https://doi.org/10.1016/J.SCITOTENV.2021.146551 DOI: https://doi.org/10.1016/j.scitotenv.2021.146551

Fan, J., & Ha, Y. (2025). Micro-and Nanoplastics and the Immune System: Mechanistic Insights and Future Directions. Immuno, 5(4), 52. https://doi.org/10.3390/immuno5040052 DOI: https://doi.org/10.3390/immuno5040052

Fournier, S. B., D’Errico, J. N., Adler, D. S., Kollontzi, S., Goedken, M. J., Fabris, L., & Stapleton, P. A. (2020). Nanopolystyrene translocation and fetal deposition after maternal inhalation in rats. Toxicological Sciences, 176(2), 244–255. https://doi.org/10.1093/toxsci/kfaa132 DOI: https://doi.org/10.21203/rs.3.rs-39676/v1

Gao, J., Chen, R., Li, W., & Liu, J. (2023). Potential Health Impact of Microplastics: A Review of Environmental and Human Exposure Evidence. Science of The Total Environment, 894, 165041. https://doi.org/10.1016/j.scitotenv.2023.165041 DOI: https://doi.org/10.1016/j.scitotenv.2023.165041

Halfar, J., Čabanová, K., Vávra, K., Delongová, P., Motyka, O., Špaček, R., Kukutschová, J., Šimetka, O., & Heviánková, S. (2023). Microplastics and additives in patients with preterm birth: The first evidence of their presence in both human amniotic fluid and placenta. Chemosphere, 343, 140301. https://doi.org/10.1016/j.chemosphere.2023.140301 DOI: https://doi.org/10.1016/j.chemosphere.2023.140301

Hasanah, U., Amqam, H., Septami, A. E., Chalid, M., & Aris, A. Z. (2024). Plasticizing Pregnancy: Microplastics Identified in Expectant Mothers’ Feces. Environmental Health Insights. https://doi.org/10.1177/11786302241235810 DOI: https://doi.org/10.1177/11786302241235810

Inam, Ö. (2025). Impact of microplastics on female reproductive health: insights from animal and human experimental studies. Archives of Gynecology and Obstetrics, 312, 77–92. https://doi.org/10.1007/s00404-024-07929-w DOI: https://doi.org/10.1007/s00404-024-07929-w

IPEN. (2024). Indonesia Microplastics Crisis. In International Pollutants Elimination Network. Retrieved from https://ipen.org/news/indonesia-microplastics-crisis

Isfarin, N. N., Fara, M. E., Krisna, H. N., Machdani, S., & Munir, M. (2024). Microplastics in Indonesian land and aquatic environment: From research activities to regulation policies. Marine Pollution Bulletin, 206. https://doi.org/10.1016/J.MARPOLBUL.2024.116813 DOI: https://doi.org/10.1016/j.marpolbul.2024.116813

Jin, X., Fu, X., Lu, W., & Wang, H. (2023). The Effects of Riverside Cities on Microplastics in River Water: A Case Study on the Southern Jiangsu Canal, China. Science of The Total Environment, 858, 159783. https://doi.org/10.1016/J.SCITOTENV.2022.159783 DOI: https://doi.org/10.1016/j.scitotenv.2022.159783

Jinesh, S., & Aditi, P. (2025). Health Implications of Microplastic Exposure in Pregnancy and Early Childhood: A Systematic Review. International Journal of Women’s Health, 17, 2805–2818. https://doi.org/10.2147/IJWH.S497366 DOI: https://doi.org/10.2147/IJWH.S497366

Jochum, M., Garcia, M., Hammerquist, A., Howell, J., Stanford, M., Liu, R., Olewine, M., El Hayek, E., Phan, E., Showalter, L., & others. (2025). Elevated Micro-and Nanoplastics Detected in Preterm Human Placentae. Research Square, rs--3. https://doi.org/10.21203/rs.3.rs-5903715/v1 DOI: https://doi.org/10.21203/rs.3.rs-5903715/v1

Kementerian Kesehatan, R. I. (2025). Peraturan Menteri Kesehatan Republik Indonesia Nomor 2 Tahun 2025 tentang Penyelenggaraan Upaya Kesehatan Reproduksi. Retrieved from https://shorturl.asia/3CfdA

Kompas.com. (2024). Indonesia penyumbang polusi plastik terbesar ke-3 di dunia. Retrieved from https://www.kompas.id/artikel/indonesia-penyumbang-polusi-plastik-terbesar-ke-3-di-dunia

Kusbijantoro, Y. B., Naufizdihar, N. A., & Adji, A. S. (2022). Potensi Ekstrak Moringa Oleifera Untuk Mengatasi Gastroenteritis Bakteri. JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia. Retrieved from https://api.semanticscholar.org/CorpusID:248223784 DOI: https://doi.org/10.53366/jimki.v9i3.460

Lara, L. Z., Bertoldi, C., Alves, N. M., & Fernandes, A. N. (2021). Sorption of Endocrine Disrupting Compounds Onto Polyamide Microplastics Under Different Environmental Conditions Behaviour and Mechanism. The Science of the Total Environment, 796. https://doi.org/10.1016/J.SCITOTENV.2021.148983 DOI: https://doi.org/10.1016/j.scitotenv.2021.148983

Li, S., Ding, F., Flury, M., Wang, Z., Xu, L., Li, S., Jones, D. L., & Wang, J. (2022). Macro- and Microplastic Accumulation in Soil After 32 Years of Plastic Film Mulching. Environmental Pollution, 300, 118945. https://doi.org/10.1016/J.ENVPOL.2022.118945 DOI: https://doi.org/10.1016/j.envpol.2022.118945

Li, X., Zhao, R., Wang, D., & Tang, L. (2024). Effects of Microplastic Exposure on Human Digestive, Reproductive, and Respiratory Systems. Environmental Science & Technology. https://doi.org/10.1021/acs.est.3c09524 DOI: https://doi.org/10.1021/acs.est.3c09524

Liu, S., Liu, X., Guo, J., Yang, R., Wang, H., Sun, Y., Chen, B., & Dong, R. (2022). The association between microplastics and microbiota in placentas and meconium: the first evidence in humans. Environmental Science & Technology, 57(46), 17774–17785. https://doi.org/10.1021/acs.est.2c04706 DOI: https://doi.org/10.1021/acs.est.2c04706

Medley, E. A., Godoy, L. E., Brown, N. J., Perera, F. P., Miller, R. L., Hernandez-Vargas, H., & Trasande, L. (2023). Systematic review of placental translocation of microplastics. Environment International, 176, 107998. https://doi.org/10.1016/j.envint.2023.107998 DOI: https://doi.org/10.1016/j.envint.2023.107998

Motomura, K., Romero, R., Galaz, J., Tao, L., Garcia-Flores, V., Xu, Y., Done, B., Arenas-Hernandez, M., Miller, D., Gutierrez-Contreras, P., & others. (2022). Fetal and maternal NLRP3 signaling is required for preterm labor and birth. JCI Insight, 7(16), e158238. https://doi.org/10.1172/jci.insight.158238 DOI: https://doi.org/10.1172/jci.insight.158238

Naderi Kalali, E., Lotfian, S., Entezar Shabestari, M., Khayatzadeh, S., Zhao, C., & Yazdani Nezhad, H. (2023). A Critical Review of the Current Progress of Plastic Waste Recycling Technology in Structural Materials. Current Opinion in Green and Sustainable Chemistry, 40, 100763. https://doi.org/10.1016/J.COGSC.2023.100763 DOI: https://doi.org/10.1016/j.cogsc.2023.100763

Oliveira, C. W. L., Oliveira, L. F. A. M., Garcia, J., Weingrill, R. B., Urschitz, J., Souza, S. T., Fonseca, E. J. S., Ospina-Prieto, S., & Borbely, A. U. (2025). First Evidence of Microplastic Accumulation in Placentas and Umbilical Cords From Pregnancies in Brazil. Anais Da Academia Brasileira de Ciencias, 3(Suppl 3). https://doi.org/10.1590/0001-3765202520241298 DOI: https://doi.org/10.1016/j.placenta.2025.08.094

Ragusa, A., Notarstefano, V., Svelato, A., Belloni, A., Gioacchini, G., Blondeel, C., Zucchelli, E., Luca, C., D’avino, S., Gulotta, A., Carnevali, O., & Giorgini, E. (2022). Raman Microspectroscopy Detection and Characterisation of Microplastics in Human Breastmilk. Polymers, 14(13). https://doi.org/10.3390/POLYM14132700 DOI: https://doi.org/10.3390/polym14132700

Ragusa, A., Svelato, A., Santacroce, C., Catalano, P., Notarstefano, V., Carnevali, O., Papa, F., Rongioletti, M. C. A., Baiocco, F., Draghi, S., D’Amore, E., Rinaldo, D., Matta, M., & Giorgini, E. (2020). Plasticenta: First evidence of microplastics in human placenta. Environment International, 146, 106274. https://doi.org/10.1016/j.envint.2020.106274 DOI: https://doi.org/10.1016/j.envint.2020.106274

Rolsky, C., & Kelkar, V. (2021). Degradation of polyvinyl alcohol in us wastewater treatment plants and subsequent nationwide emission estimate. International Journal of Environmental Research and Public Health, 18(11). https://doi.org/10.3390/IJERPH18116027/S1 DOI: https://doi.org/10.3390/ijerph18116027

Sharma, R., Kumari, U., & Kumar, S. (2024). Impact of Microplastics on Pregnancy and Fetal Development. A Systematic Review. Cureus, 16(5). https://doi.org/10.7759/cureus.60548 DOI: https://doi.org/10.7759/cureus.60712

Wang, D., Su, L., Ruan, H. D., Chen, J., Lu, J., Lee, C. H., & Jiang, S. Y. (2021). Quantitative and Qualitative Determination of Microplastics in Oyster, Seawater and Sediment From the Coastal Areas in Zhuhai, China. Marine Pollution Bulletin, 164, 112000. https://doi.org/10.1016/J.MARPOLBUL.2021.112000 DOI: https://doi.org/10.1016/j.marpolbul.2021.112000

Wang, X., Li, J., Zhang, M., Chen, H., & Liu, P. (2025). A review of microplastic pollution and human health risk assessment. Frontiers in Environmental Science, 13, 1606332. https://doi.org/10.3389/fenvs.2025.1606332 DOI: https://doi.org/10.3389/fenvs.2025.1606332

Wright, S. L., & Kelly, F. J. (2017). Plastic and Human Health: A Micro Issue? Environmental Science & Technology, 51(12), 6634–6647. https://doi.org/10.1021/acs.est.7b00423 DOI: https://doi.org/10.1021/acs.est.7b00423

Yang, L., Zhang, Y., Kang, S., Wang, Z., & Wu, C. (2021). Microplastics in Soil: A Review on Methods, Occurrence, Sources, and Potential Risk. Science of The Total Environment, 780, 146546. https://doi.org/10.1016/J.SCITOTENV.2021.146546 DOI: https://doi.org/10.1016/j.scitotenv.2021.146546

Yu, S., Mu, Y., Wang, K., Wang, L., Wang, C., Yang, Z., Liu, Y., Li, S., & Zhang, M. (2024). Gestational exposure to 1-NP induces ferroptosis in placental trophoblasts via CYP1B1/ERK signaling pathway leading to fetal growth restriction. Chemico-Biological Interactions, 387, 110812. https://doi.org/10.1016/j.cbi.2023.110812 DOI: https://doi.org/10.1016/j.cbi.2023.110812

Zhao, X., & You, F. (2024). Microplastic Human Dietary Uptake from 1990 to 2018 Grew across 109 Major Developing and Industrialized Countries but Can Be Halved by Plastic Debris Removal. Environmental Science & Technology, 58, 19091–19102. https://doi.org/10.1021/acs.est.4c00010 DOI: https://doi.org/10.1021/acs.est.4c10354

Zhu, M., Li, X., Lin, W., Zeng, D., Yang, P., Ni, W., Chen, Z., Lin, B., Lai, L., Ouyang, Z., & Fan, J. (2024). Microplastic Particles Detected in Fetal Cord Blood, Placenta, and Meconium: A Pilot Study of Nine Mother–Infant Pairs in South China. Toxics, 12(12), 850. https://doi.org/10.3390/toxics12120850 DOI: https://doi.org/10.3390/toxics12120850

Zurub, R. E., Cariaco, Y., Wade, M. G., & Bainbridge, S. A. (2023). Microplastics exposure: Implications for human fertility, pregnancy and child health. Frontiers in Endocrinology, 14, 1330396. https://doi.org/10.3389/fendo.2023.1330396 DOI: https://doi.org/10.3389/fendo.2023.1330396

Author Biographies

Arga Setyo Adji, Airlangga University

Author Origin : Indonesia

Alan Dharmasaputra, Hang Tuah University

Author Origin : Indonesia

Florencia Audrey, Hang Tuah University

Author Origin : Indonesia

Grace Eka Wijayanti, Hang Tuah University

Author Origin : Indonesia

Luh Putu Diah Ayuning, Hang Tuah University

Author Origin : Indonesia

Bambang Edi Suwito, Universitas Nahdlatul Ulama Surabaya

Author Origin : Indonesia

Angela Puspita, Hang Tuah University

Author Origin : Indonesia

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How to Cite

Adji, A. S., Dharmasaputra, A., Audrey, F., Wijayanti, G. E., Ayuning, L. P. D., Suwito, B. E., & Puspita, A. (2025). Microplastic and Nanoplastic Pollution in Pregnant Women: Contribution to Preterm Birth and Health Policy Implications. Jurnal Penelitian Pendidikan IPA, 11(11), 172–182. https://doi.org/10.29303/jppipa.v11i11.13225