Intermittent Fasting as New Approaches as Anti Aging for Preventing Age-associated Diseases
DOI:
10.29303/jppipa.v9i11.5492Published:
2023-11-25Issue:
Vol. 9 No. 11 (2023): NovemberKeywords:
Anti aging, Disease, Intermittent FastingReview
Downloads
How to Cite
Downloads
Metrics
Abstract
The aging process is inherently linked to an increased susceptibility to various chronic conditions, such as cardiovascular diseases, diabetes, and neurodegenerative disorders. The aim of this research is to delves into the current body of knowledge surrounding intermittent fasting and its potential implications in preventing age-related diseases. The methodological approach used in this research is systematic review. Research search using PRISMA strategy by searching journal articles from various databases including Scopus, Proquest, Science Direct, CINAHL, and Google Scholar in the last five years from 2019 to 2023. The results of PRISMA found 333 articles identified through the five databases contained in research methods and screened through titles. Result this research is the promising role of intermittent fasting in promoting anti-aging effects and preventing age-associated diseases through its multifaceted influence on cellular and molecular mechanisms. As an innovative avenue, intermittent fasting holds the potential to revolutionize strategies aimed at enhancing healthy aging and longevity.
intermittent fasting as new approaches as anti aging for preventing age-associated diseases
Â
References
Abdullah, S. R., Azizul, N. H., Zin, R. M. W. M., Sulaiman, N. S., Khalid, N. M., Jahn, R. J. M. S. M., Khalil, M. K. N., Abu Seman, N., Abidin, N. A. Z., Ali, A., Tan, Y. Z., Omar, A., Johari, M. Z., Aziz, N. S. A., Baharudin, A., Seman, Z., Wong, N. I., Rasip, M. L. M., Yusof, H. M., & Noh, M. F. M. (2022). Cardiometabolic and Anthropometric Outcomes of Intermittent Fasting Among Civil Servants With Overweight and Obesity: Study Protocol for a Nonrandomized Controlled Trial. JMIR Research Protocols, 11(8). https://doi.org/10.2196/33801
Alotaibi, M. I., Elsamad, G., Aljardahi, A. N., Alghamdi, A. N., Alotaibi, A. I., Alorabi, H. M., Alzahrani, K. M., & Abdel-Moneim, A. S. (2023). Changes in dietary and lifestyle behaviors and mental stress among medical students upon Ramadan diurnal intermittent fasting: a prospective cohort study from Taif/Saudi Arabia. BMC Public Health, 23(1), 1462. https://doi.org/10.1186/s12889-023-16385-1
Andrieieva, O., Hakman, A., Kashuba, V., Vasylenko, M., Patsaliuk, K., Koshura, A., & Istyniuk, I. (2019). Effects Of Physical Activity On Aging Processes In Elderly Persons. Journal of Physical Education and Sport, 19. https://doi.org/10.7752/jpes.2019.s4190
Brocchi, A., Rebelos, E., Dardano, A., Mantuano, M., & Daniele, G. (2022). Effects of Intermittent Fasting on Brain Metabolism. In Nutrients, 14 (6). https://doi.org/10.3390/nu14061275
Chen, S., Han, R., & Liu, H. (2022). A Bibliometric and Visualization Analysis of Intermittent Fasting. Frontiers in Public Health, 10. https://doi.org/10.3389/fpubh.2022.946795
Cignarella, F., Cantoni, C., Ghezzi, L., Salter, A., Dorsett, Y., Chen, L., Phillips, D., Weinstock, G. M., Fontana, L., Cross, A. H., Zhou, Y., & Piccio, L. (2018). Intermittent Fasting Confers Protection in CNS Autoimmunity by Altering the Gut Microbiota. Cell Metabolism, 27(6). https://doi.org/10.1016/j.cmet.2018.05.006
da-Silva, R. A. D., Szmuchrowski, L. A., Rosa, J. P. P., Santos, M. A. P. Dos, de Mello, M. T., Savoi, L., Porto, Y. F., de Assis Dias Martins Júnior, F., & Drummond, M. D. M. (2023). Intermittent Fasting Promotes Weight Loss without Decreasing Performance in Taekwondo. Nutrients, 15(14). https://doi.org/10.3390/nu15143131
de-Cabo, R., & Mattson, M. P. (2019). Effects of Intermittent Fasting on Health, Aging, and Disease. New England Journal of Medicine, 381(26). https://doi.org/10.1056/nejmra1905136
Dokpuang, D., Zhiyong Yang, J., Nemati, R., He, K., Plank, L. D., Murphy, R., & Lu, J. (2023). Magnetic resonance study of visceral, subcutaneous, liver and pancreas fat changes after 12 weeks intermittent fasting in obese participants with prediabetes. Diabetes Research and Clinical Practice 202, 110775. https://doi.org/10.1016/j.diabres.2023.110775
Dong, T. A., Sandesara, P. B., Dhindsa, D. S., Mehta, A., Arneson, L. C., Dollar, A. L., Taub, P. R., & Sperling, L. S. (2020). Intermittent Fasting: A Heart Healthy Dietary Pattern? In American Journal of Medicine 133 (8). https://doi.org/10.1016/j.amjmed.2020.03.030
Dou, Y., Jiang, Y., Chen, X., Zhang, Y., Wang, Y., Chen, H., He, W., & Yan, W. (2023). Intermittent dietary carbohydrate restriction versus calorie restriction and cardiometabolic profiles: A randomized trial. Obesity, 31 (9). https://doi.org/10.1002/oby.23855
Duregon, E., Pomatto-Watson, L. C. D. D., Bernier, M., Price, N. L., & de Cabo, R. (2021). Intermittent fasting: from calories to time restriction. In GeroScience, 43 (8). https://doi.org/10.1007/s11357-021-00335-z
Elias, A., Padinjakara, N., & Lautenschlager, N. T. (2023). Effects of intermittent fasting on cognitive health and Alzheimer’s disease. Nutrition Reviews. 81 (9). 1225-1233 https://doi.org/10.1093/nutrit/nuad021
Elsworth, R. L., Monge, A., Perry, R., Hinton, E. C., Flynn, A. N., Whitmarsh, A., Hamilton-Shield, J. P., Lawrence, N. S., & Brunstrom, J. M. (2023). The Effect of Intermittent Fasting on Appetite: A Systematic Review and Meta-Analysis. Nutrients 15 (11). https://doi.org/10.3390/nu15112604
Fanti, M., Mishra, A., Longo, V. D., & Brandhorst, S. (2021). Time-Restricted Eating, Intermittent Fasting, and Fasting-Mimicking Diets in Weight Loss. In Current Obesity Reports, 10 (2). https://doi.org/10.1007/s13679-021-00424-2
Gonzales, M. M., Garbarino, V. R., Pollet, E., Palavicini, J. P., Kellogg, D. L., Kraig, E., & Orr, M. E. (2022). Biological aging processes underlying cognitive decline and neurodegenerative disease. In Journal of Clinical Investigation, 132(10). https://doi.org/10.1172/JCI158453
Gudden, J., Arias Vasquez, A., & Bloemendaal, M. (2021). The effects of intermittent fasting on brain and cognitive function. In Nutrients. 13 (9). https://doi.org/10.3390/nu13093166
Han, S. C., Kang, J. I., Choi, Y. K., Boo, H. J., Yoon, W. J., Kang, H. K., & Yoo, E. S. (2023). Intermittent Fasting Modulates Immune Response by Generating Tregs via TGF-β Dependent Mechanisms in Obese Mice with Allergic Contact Dermatitis. Biomolecules & therapeutics, 10 (2023). https://doi.org/10.4062/biomolther.2023.053
Hanun, J. N., Hassan, F., & Jiang, J. J. (2021). Occurrence, Fate, And Sorption Behavior Of Contaminants Of Emerging Concern To Microplastics: Influence Of The Weathering/Aging Process. Journal of Environmental Chemical Engineering, 9 (5) https://doi.org/10.1016/j.jece.2021.106290
Kim, B. H., Joo, Y., Kim, M. S., Choe, H. K., Tong, Q., & Kwon, O. (2021). Effects of intermittent fasting on the circulating levels and circadian rhythms of hormones. In Endocrinology and Metabolis, 36 (4). https://doi.org/10.3803/ENM.2021.405
Küçük, A. N., & Çiftçi, S. (2023). The role of intermittent fasting and the ketogenic diet in cancer disease: can they replace the Mediterranean diet?. European Journal of Cancer Prevention : The Official Journal of the European Cancer Prevention Organisation (ECP), 32(6):533-543. https://doi.org/10.1097/cej.0000000000000820
Lange, M., Nadkarni, D., Martin, L., Newberry, C., Kumar, S., & Kushner, T. (2023). Intermittent fasting improves hepatic end points in nonalcoholic fatty liver disease: A systematic review and meta-analysis. Hepatology Communications, 7(8). https://doi.org/10.1097/hc9.0000000000000212
Liu, H., Javaheri, A., Godar, R. J., Murphy, J., Ma, X., Rohatgi, N., Mahadevan, J., Hyrc, K., Saftig, P., Marshall, C., McDaniel, M. L., Remedi, M. S., Razani, B., Urano, F., & Diwan, A. (2017). Intermittent Fasting Preserves Beta-Cell Mass In Obesity-Induced Diabetes Via The Autophagy-Lysosome Pathway. Autophagy, 13(11). https://doi.org/10.1080/15548627.2017.1368596
Maretalinia, Rusmitasari, H., Supriatin, Amaliah, L., Sukmawati, E., & Suwarni, L. (2023). Factors influencing the utilization of the Modern Family Planning (MFP) Method Under The National Health Insurance In Indonesia: An Analysis Of The 2017 IDHS. Public Health of Indonesia, 9(2). https://doi.org/10.36685/phi.v9i2.694
Marjot, T., Tomlinson, J. W., Hodson, L., & Ray, D. W. (2023). Timing of energy intake and the therapeutic potential of intermittent fasting and time-restricted eating in NAFLD. Gut, 2023 (329998). https://doi.org/10.1136/gutjnl-2023-329998
Mattson, M. P., Longo, V. D., & Harvie, M. (2017). Impact of intermittent fasting on health and disease processes. In Ageing Research Reviews, 39, October 2017, 46-58. https://doi.org/10.1016/j.arr.2016.10.005
Moleong, L. J. (2018). Metodologi Penelitian Kualitatif cetakan XI. Bandung: PT Remaja Rosdakarya.
Nowosad, K., & Sujka, M. (2021). Effect of Various Types of Intermittent Fasting (IF) on Weight Loss and Improvement of Diabetic Parameters in Human. In Current Nutrition Reports, 10 (2). https://doi.org/10.1007/s13668-021-00353-5
Oliveira, L. da C., Morais, G. P., de Oliveira, F. P., Mata, M. M., Veras, A. S. C., da Rocha, A. L., Elias, L. L. K., Teixeira, G. R., de Moraes, C., Cintra, D. E., Ropelle, E. R., de Moura, L. P., Pauli, J. R., de Freitas, E. C., Rorato, R., & da Silva, A. S. R. (2023). Intermittent fasting combined with exercise training reduces body mass and alleviates hypothalamic disorders induced by high-fat diet intake. Journal of Nutritional Biochemistry, 119. 109372 https://doi.org/10.1016/j.jnutbio.2023.109372
Pan, Y. Le, Kalume, A., Wang, C., & Santarpia, J. (2021). Atmospheric aging processes of bioaerosols under laboratory-controlled conditions: A review. In Journal of Aerosol Science, 155, 105767 https://doi.org/10.1016/j.jaerosci.2021.105767
Parveen, S., & Alhazmi, Y. A. (2022). Impact of Intermittent Fasting on Metabolic Syndrome and Periodontal Disease—A Suggested Preventive Strategy to Reduce the Public Health Burden. In International Journal of Environmental Research and Public Health, 19 (21). https://doi.org/10.3390/ijerph192114536
Pelc, M. A. (2023). The Effects Of Intermittent Fasting And A Low-Carbohydrate Diet On Type 2 Diabetes. Jaapa, 36(7), 26–29. https://doi.org/10.1097/01.jaa.0000923536.23229.d3
Roy, Y. J., & Lyutakov, I. (2023). The effect of Ramadan and intermittent fasting on the development of Helicobacter pylori-induced peptic ulcers. British Journal of Hospital Medicine (London, England : 2005), 84(7), 1–6. https://doi.org/10.12968/hmed.2022.0369
Schmidt, M. W., Brenner, W., Gebhard, S., Schmidt, M., Singer, S., Weidenbach, L., Hahn, H., Puzankova, D., Blau-Schneider, B., Lehnert, A., Battista, M. J., Almstedt, K., Lütkemeyer, A., Radsak, M. P., Mähringer-Kunz, A., Krajnak, S., Linz, V. C., Schwab, R., Gabriel, B., & Anic, K. (2023). Effects Of Intermittent Fasting On Quality Of Life Tolerance Of Chemotherapy In Patients With Gynecological Cancers: Study Protocol Of A Randomized-Controlled Multi-Center Trial. Frontiers in Oncology, 13 (2023). https://doi.org/10.3389/fonc.2023.1222573
Silverii, G. A., Cresci, B., Benvenuti, F., Santagiuliana, F., Rotella, F., & Mannucci, E. (2023). Effectiveness of intermittent fasting for weight loss in individuals with obesity: A meta-analysis of randomized controlled trials. Nutrition, Metabolism and Cardiovascular Diseases, 33 (8), 1481-1489. https://doi.org/10.1016/j.numecd.2023.05.005
Stockman, M. C., Thomas, D., Burke, J., & Apovian, C. M. (2018). Intermittent Fasting: Is the Wait Worth the Weight? Current obesity reports, 7 (2). https://doi.org/10.1007/s13679-018-0308-9
Su, Y., Zhang, Z., Zhu, J., Shi, J., Wei, H., Xie, B., & Shi, H. (2021). Microplastics Act As Vectors For Antibiotic Resistance Genes In Landfill Leachate: The Enhanced Roles Of The Long-Term Aging Process. Environmental Pollution, 270, 116278. https://doi.org/10.1016/j.envpol.2020.116278
Sugiyono. (2019). Metode Penelitian Kuantitatif, Kualitatif, dan R&D (1st ed.). Bandung: Penerbit Alfabeta.
Sugiyono. (2020). Metode Penelitian Kualitatif. Bandung : Alfabeta.
Swift, A., Liew, S., Weinkle, S., Garcia, J. K., & Silberberg, M. B. (2021). The Facial Aging Process from the “inside Out.†Aesthetic Surgery Journal, 41(10). https://doi.org/10.1093/asj/sjaa339
Tay, A., Pringle, H., Penning, E., Plank, L. D., & Murphy, R. (2020). Profast: A Randomized Trial Assessing The Effects Of Intermittent Fasting And Lacticaseibacillus Rhamnosus Probiotic Among People With Prediabetes. Nutrients, 12(11). https://doi.org/10.3390/nu12113530
Tinsley, G. M., & La Bounty, P. M. (2015). Effects of intermittent fasting on body composition and clinical health markers in humans. Nutrition Reviews, 73(10). https://doi.org/10.1093/nutrit/nuv041
Valentina, E., Carolina, A., Yaroleth, C., Fabiana, S., Emilia, B., Angelica, P., & Sharon, V. (2023). Intermittent fasting for health care, a review. In Archivos Latinoamericanos de Nutricion (Vol. 73, Issue 1). https://doi.org/10.37527/2023.73.1.006
Xiong, F., Jiang, K., Wu, Y., Lou, C., Ding, C., Zhang, W., Zhang, X., Li, C., Zheng, H., & Gao, H. (2023). Intermittent fasting alleviates type 1 diabetes-induced cognitive dysfunction by improving the frontal cortical metabolic disorder. Biochimica et Biophysica Acta - Molecular Basis of Disease, 1869(7). https://doi.org/10.1016/j.bbadis.2023.166725
Xu, S., Jiang, Y., Zhang, Y., Xu, W., Zhang, H., Yan, Q., Gao, L., & Shang, L. (2022). Dietary recommendations for fasting days in an alternate-day intermittent fasting pattern: A randomized controlled trial. Nutrition, 102. 111735. https://doi.org/10.1016/j.nut.2022.111735
Yang, M., Chen, W., He, L., Liu, D., Zhao, L., & Wang, X. (2022). Intermittent Fasting—A Healthy Dietary Pattern for Diabetic Nephropathy. Nutrients, 14 (9). https://doi.org/10.3390/nu14193995
Ye, Y. F., Zhang, M. X., Lin, Z., & Tang, L. (2022). Is Intermittent Fasting Better Than Continuous Energy Restriction for Adults with Overweight and Obesity? In Diabetes, Metabolic Syndrome and Obesity (Vol. 15). https://doi.org/10.2147/DMSO.S376409
Yücel, A. H.Y, Adar, A., Korkut, B., Kalem, P., İncı, H., & Adahan, D. (2022). The effects of intermittent fasting on nighttime blood pressure levels. Journal of Experimental and Clinical Medicine (Turkey), 39(3). https://doi.org/10.52142/omujecm.39.3.38
Zang, B. Y., He, L. X., & Xue, L. (2022). Intermittent Fasting: Potential Bridge of Obesity and Diabetes to Health? In Nutrients, 14 (5). https://doi.org/10.3390/nu14050981
Zhang, Q., Zhang, C., Wang, H., Ma, Z., Liu, D., Guan, X., Liu, Y., Fu, Y., Cui, M., & Dong, J. (2022). Intermittent Fasting versus Continuous Calorie Restriction: Which Is Better for Weight Loss? Nutrients, 14(9). https://doi.org/10.3390/nu14091781
Author Biographies
Yesi Rosalia, Udayana University
I Wayan Juli Sumadi, Medical Faculty, Udayana University
License
Copyright (c) 2023 Yesi Rosalia, I Wayan Juli Sumadi

This work is licensed under a Creative Commons Attribution 4.0 International License.
Authors who publish with Jurnal Penelitian Pendidikan IPA, agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution 4.0 International License (CC-BY License). This license allows authors to use all articles, data sets, graphics, and appendices in data mining applications, search engines, web sites, blogs, and other platforms by providing an appropriate reference. The journal allows the author(s) to hold the copyright without restrictions and will retain publishing rights without restrictions.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in Jurnal Penelitian Pendidikan IPA.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).