The Effectiveness of Bougainvillea (Bougainvillea spectabilis willd) Extract on Reducing Blood Glucose in Hypercholesterolaemia White Rats

Authors

Muhammad Fakhrul Hardani , Baharuddin Hamzah , Ririen Hardani , Magfirah , Sitti Rahmawati , Purnama Ningsih

DOI:

10.29303/jppipa.v11i1.9762

Published:

2025-02-03

Issue:

Vol. 11 No. 1 (2025): In Progress

Keywords:

Bougainvillea Extract, Blood Glucose, Hypercholesterolemia model, White rats

Research Articles

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How to Cite

Hardani, M. F., Hamzah, B., Hardani, R., Magfirah, Rahmawati, S., & Ningsih, P. (2025). The Effectiveness of Bougainvillea (Bougainvillea spectabilis willd) Extract on Reducing Blood Glucose in Hypercholesterolaemia White Rats. Jurnal Penelitian Pendidikan IPA, 11(1), 842–847. https://doi.org/10.29303/jppipa.v11i1.9762

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Abstract

Bougainvillea leaves are often used by the public as a treatment by drinking boiled water, but their use as a blood sugar-lowering agent is not supported by scientific data. The purpose of this study was to determine the effect of reducing blood glucose levels and to determine the dose of extract that is effective in in white rats. The plant's herbal extract was prepared using the reflux method with 90% ethanol solvent. This study uses a laboratory experimental method to compare blood glucose levels in white rats before and after administration of herb extract at doses of 100, 200, and 300 mg/kg BW orally using high-fat feed induction and streptozotocin. Blood glucose levels were measured using a glucometer, and mice were declared positive for diabetes with fasting blood sugar levels above 126 mg/dL. The number of test animals used in this study was 30 mice, divided into 6 groups. A randomized block design was used as the research design. The study's findings revealed that administering Bougainville spectabilis willd herb extract at doses of 100, 200, and 300 mg/kg BW can reduce blood glucose in test animals with an effective dose of 200 mg/kg BW

References

Abarca-Vargas, R., & Petricevich, V. L. (2018). Bougainvillea: A Review on Phytochemistry, Pharmacology, and Toxicology. Evidence-Based Complementary and Alternative Medicine, 2018(1). https://doi.org/10.1155/2018/9070927

Abo-Elghiet, F., Ahmed, A. H., Aly, H. F., Younis, E. A., Rabeh, M. A., Alshehri, S. A., Alshahrani, K. S. A., & Mohamed, S. A. (2023a). D-Pinitol Content and Antioxidant and Antidiabetic Activities of Five Bougainvillea spectabilis Willd. Cultivars. Pharmaceuticals, 16(7), 1008. https://doi.org/10.3390/ph16071008

Abo-Elghiet, F., Ahmed, A. H., Aly, H. F., Younis, E. A., Rabeh, M. A., Alshehri, S. A., Alshahrani, K. S. A., & Mohamed, S. A. (2023b). D-Pinitol Content and Antioxidant and Antidiabetic Activities of Five Bougainvillea spectabilis Willd. Cultivars. Pharmaceuticals 2023, Vol. 16, Page 1008, 16(7), 1008. https://doi.org/10.3390/PH16071008

Afzal, M. U., Pervaiz, M., Ejaz, A., Bajwa, E., Naz, S., Saeed, Z., Ullah, S., Gillani, S. S., Kan, R. R. M., & Younas, U. (2023). A comprehensive study of the sources, extraction methods and structures of the Saponin compounds for its antidiabetic activity. Biocatalysis and Agricultural Biotechnology, 54, 102913. https://doi.org/10.1016/j.bcab.2023.102913

Alam, S., Sarker, M. M. R., Sultana, T. N., Chowdhury, M. N. R., Rashid, M. A., Chaity, N. I., Zhao, C., Xiao, J., Hafez, E. E., Khan, S. A., & Mohamed, I. N. (2022a). Antidiabetic Phytochemicals From Medicinal Plants: Prospective Candidates for New Drug Discovery and Development. Frontiers in Endocrinology, 13, 800714. https://doi.org/10.3389/FENDO.2022.800714

Alam, S., Sarker, Md. M. R., Sultana, T. N., Chowdhury, Md. N. R., Rashid, M. A., Chaity, N. I., Zhao, C., Xiao, J., Hafez, E. E., Khan, S. A., & Mohamed, I. N. (2022b). Antidiabetic Phytochemicals From Medicinal Plants: Prospective Candidates for New Drug Discovery and Development. Frontiers in Endocrinology, 13. https://doi.org/10.3389/fendo.2022.800714

Algonaiman, R., Alharbi, H. F., & Barakat, H. (2022). Antidiabetic and Hypolipidemic Efficiency of Lactobacillus plantarum Fermented Oat (Avena sativa) Extract in Streptozotocin-Induced Diabetes in Rats. Fermentation 2022, Vol. 8, Page 267, 8(6), 267. https://doi.org/10.3390/FERMENTATION8060267

AL-Ishaq, R. K., Abotaleb, M., Kubatka, P., Kajo, K., & Büsselberg, D. (2019). Flavonoids and Their Anti-Diabetic Effects: Cellular Mechanisms and Effects to Improve Blood Sugar Levels. Biomolecules, 9(9), 430. https://doi.org/10.3390/biom9090430

American Diabetes Association (ADA). (2022). Classification and Diagnosis of Diabetes: Standards of Medical Care in Diabetes. Diabetes Care, 45(Supplement_1), S17–S38. https://doi.org/10.2337/dc22-S002

Chauhan, P., Mahajan, S., Kulshrestha, A., Shrivastava, S., Sharma, B., Goswamy, H. M., & Prasad, G. B. K. S. (2016a). Bougainvillea spectabilis Exhibits Antihyperglycemic and Antioxidant Activities in Experimental Diabetes. Journal of Evidence-Based Complementary & Alternative Medicine, 21(3), 177–185. https://doi.org/10.1177/2156587215595152

Chauhan, P., Mahajan, S., Kulshrestha, A., Shrivastava, S., Sharma, B., Goswamy, H. M., & Prasad, G. B. K. S. (2016b). Bougainvillea spectabilis Exhibits Antihyperglycemic and Antioxidant Activities in Experimental Diabetes. Journal of Evidence-Based Complementary & Alternative Medicine, 21(3), 177–185. https://doi.org/10.1177/2156587215595152

Chiorcea-Paquim, A. M. (2023). Electrochemistry of Flavonoids: A Comprehensive Review. International Journal of Molecular Sciences 2023, Vol. 24, Page 15667, 24(21), 15667. https://doi.org/10.3390/IJMS242115667

Dias Soares, J., Pereira Leal, A. B., Silva, J., Almeida, JacksonR. G. S., & de Oliveira, H. (2017). Influence of flavonoids on mechanism of modulation of insulin secretion. Pharmacognosy Magazine, 13(52), 639. https://doi.org/10.4103/pm.pm_87_17

Hussain, T., Tan, B., Murtaza, G., Liu, G., Rahu, N., Saleem Kalhoro, M., Hussain Kalhoro, D., Adebowale, T. O., Usman Mazhar, M., Rehman, Z. ur, Martínez, Y., Akber Khan, S., & Yin, Y. (2020). Flavonoids and type 2 diabetes: Evidence of efficacy in clinical and animal studies and delivery strategies to enhance their therapeutic efficacy. Pharmacological Research, 152, 104629. https://doi.org/10.1016/J.PHRS.2020.104629

Jain, N. K., & Singhai, A. K. (2011). Protective effects of Phyllanthus acidus (L.) Skeels leaf extracts on acetaminophen and thioacetamide induced hepatic injuries in Wistar rats. Asian Pacific Journal of Tropical Medicine, 4(6), 470–474. https://doi.org/10.1016/S1995-7645(11)60128-4

Jiang, Y., Feng, C., Shi, Y., Kou, X., & Le, G. (2022). Eugenol improves high-fat diet/streptomycin-induced type 2 diabetes mellitus (T2DM) mice muscle dysfunction by alleviating inflammation and increasing muscle glucose uptake. Frontiers in Nutrition, 9, 1039753. https://doi.org/10.3389/FNUT.2022.1039753/BIBTEX

Joshi, B. N., Bhat, M., Kothiwale, S. K., Tirmale, A. R., & Bhargava, S. Y. (2011). Antidiabetic Properties of Azardiracta indica and Bougainvillea spectabilis: In Vivo Studies in Murine Diabetes Model. Evidence-Based Complementary and Alternative Medicine : ECAM, 2011, 561625. https://doi.org/10.1093/ECAM/NEP033

Kaushik, D., Kumar, M., Proestos, C., Oz, F., Gupta, P., Kumar, A., Kundu, P., Kaur, J., kumar, V., Anjali, A., & Xiang, J. (2023). A narrative review on the anti-inflammatory efficacy of Bougainvillea spectabilis Willd. and its various applications. Journal of Agriculture and Food Research, 12, 100570. https://doi.org/10.1016/j.jafr.2023.100570

Kumar, M., Kaushik, D., Kaur, J., Proestos, C., Oz, F., Kumar, A., Anjali, A., Elobeid, T., Terzioğlu, M. E., & Xiao, J. (2022). Assessment of Anti-Obesity Potential and Techno-Functional Properties of Bougainvillea spectabilis Willd. Bracts. Separations 2022, Vol. 9, Page 399, 9(12), 399. https://doi.org/10.3390/SEPARATIONS9120399

Mandal, M., Sarkar, M., Khan, A., Biswas, M., Masi, A., Rakwal, R., Agrawal, G. K., Srivastava, A., & Sarkar, A. (2022). Reactive Oxygen Species (ROS) and Reactive Nitrogen Species (RNS) in plants– maintenance of structural individuality and functional blend. Advances in Redox Research, 5, 100039. https://doi.org/10.1016/J.ARRES.2022.100039

Paul, S., Ali, A., & Katare, R. (2020). Molecular complexities underlying the vascular complications of diabetes mellitus – A comprehensive review. Journal of Diabetes and Its Complications, 34(8), 107613. https://doi.org/10.1016/j.jdiacomp.2020.107613

Russo, B., Picconi, F., Malandrucco, I., & Frontoni, S. (2019). Flavonoids and Insulin-Resistance: From Molecular Evidences to Clinical Trials. International Journal of Molecular Sciences, 20(9), 2061. https://doi.org/10.3390/ijms20092061

Sarkar, C., Chaudhary, P., Jamaddar, S., Janmeda, P., Mondal, M., Mubarak, M. S., & Islam, M. T. (2022). Redox Activity of Flavonoids: Impact on Human Health, Therapeutics, and Chemical Safety. Chemical Research in Toxicology, 35(2), 140–162. https://doi.org/10.1021/ACS.CHEMRESTOX.1C00348/ASSET/IMAGES/MEDIUM/TX1C00348_0009.GIF

Sarswati Prakash, B., Bhawana, K., Pooja, N., Vishwadeepak, K., & Divya, N. (2022). Pretreatment Of Albino Rats With Poly Herbal Extract Of Andrographis Paniculata, Bougainvillea Spectabilis And Cinnamomum Tamala For Protection Against Streptozotocin Induced Diabetes Mellitus Pretreatment Of Albino Rats With Poly Herbal Extract Of Andrographis Paniculata, Bougainvillea Spectabilis And Cinnamomum Tamala For Protection Against Streptozotocin Induced Diabetes Mellitus. NeuroQuantology, 20(10), 4022–4033. https://doi.org/10.14704/nq.2022.20.10.NQ55393

Saxena, N., Chudasama, Y., Chawada, H., Kumar, C., Sanyal, D., Dasgupta, S., & Chaturvedi, A. K. (2023). Antibacterial And Antifungal Properties Of Bougainvillea Spectabilis Andtecoma Stans Plant Extracts Against Human Pathogens. Journal of Survey in Fisheries Sciences. https://doi.org/10.53555/sfs.v10i3.2602

Singh, H., & Singh, H. (2024). Comprehensive Review:-Bougainvillea Spectabilis 1*. World Journal of Pharmaceutical Research, 13. https://doi.org/10.20959/wjpr202411-32660

Sutjiatmo, A. B., Sukandar, E. Y., Sinaga, R., Hernawati, R., & Vikasari, S. N. (2013). Efek Antikolesterol Ekstrak Etanol Daun Cerme (Phyllanthus acidus (L.) Skeels) Pada Tikus Wistar Betina. Kartika Jurnal Ilmiah Farmasi, 1(1). https://doi.org/10.26874/kjif.v1i1.1

Author Biographies

Muhammad Fakhrul Hardani, Tadulako University

Baharuddin Hamzah, Tadulako University

Ririen Hardani, Tadulako University

Magfirah, Tadulako University

Sitti Rahmawati, Tadulako University

Purnama Ningsih, Tadulako University

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Copyright (c) 2025 Muhammad Fakhrul Hardani, Baharuddin Hamzah, Ririen Hardani, Magfirah, Sitti Rahmawati, Purnama Ningsih

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