Optimizing Ketamine-Propofol Collaboration to Prevent SpO₂ Decrease in TIVA Patients at RSU Emanuel Banjarnegara

Authors

Rahmaya Nova Handayani , Sakhfa Syesar Novaliyanto , Surtiningsih

DOI:

10.29303/jppipa.v11i4.10982

Published:

2025-04-25

Issue:

Vol. 11 No. 4 (2025): April: In Progress

Keywords:

Anesthesia, Ketamine, Oxygen saturation (SpO2), Propofol, Total intravenous anesthesia (TIVA)

Research Articles

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Handayani, R. N., Novaliyanto, S. S., & Surtiningsih. (2025). Optimizing Ketamine-Propofol Collaboration to Prevent SpO₂ Decrease in TIVA Patients at RSU Emanuel Banjarnegara. Jurnal Penelitian Pendidikan IPA, 11(4), 216–223. https://doi.org/10.29303/jppipa.v11i4.10982
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Abstract

Introduction: Total Intravenous Anesthesia (TIVA) is a widely used anesthetic technique that relies entirely on intravenous agents. However, one of its challenges is the potential reduction in oxygen saturation (SpO₂) during induction. Ketamine and propofol are commonly used anesthetic agents and their combination is hypothesized to optimize hemodynamic stability and prevent SpO₂ decline. Objectives: This study aims to evaluate the effectiveness of ketamine-propofol collaboration in maintaining oxygen saturation during TIVA induction at RSU Emanuel Banjarnegara. Methods: This study was a quasi-experimental study with 50 TIVA patients who met the inclusion criteria. Result: The study found that patients receiving the ketamine-propofol combination exhibited a more stable SpO₂ level compared to those receiving propofol alone. The mean decrease in SpO₂ was significantly lower in the combination group (p < 0.05), indicating the protective effect of ketamine in preventing hypoxia. The combo group also maintained hemodynamic indicators including blood pressure and heart rate better. Conclusion: The simultaneous injection of Ketamine and Propofol is beneficial in preventing a drop in SpO₂ 1 minute after induction of anesthesia compared to the combination of Propofol alone.

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Author Biographies

Rahmaya Nova Handayani, Universitas Harapan Bangsa

Sakhfa Syesar Novaliyanto, Universitas Harpan Bangsa

Surtiningsih, Universitas Harpan Bangsa

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