Design of PCF-SPR for Early Detection of Skin Cancer Infected Cells
DOI:
10.29303/jppipa.v8i5.2120Published:
2022-11-30Downloads
Abstract
In this work, we carried out a numerical investigation of the PCF-SPR biosensor for the early detection of infected skin cancer cells and healthy cells. The study was conducted using the COMSOL Multiphysics-based FEM method. The dielectric material used in this PCF design is fused silica, while the plasmonic material is gold. The study was conducted to test the effect of the thickness of the plasmonic layer and the size of the air hole diameter on the PCF-SPR. It was found that the larger the diameter of the air hole in the proposed sensor gives a smaller confinement loss value, while the thicker the plasmonic material used also gives a small confinement loss value. The proposed PCF-SPR has a wavelength sensitivity in detecting skin cancer-infected cells of 7000 nm/RIU. These results indicate that the proposed sensor has a good performance in detecting cells infected with skin cancer.
Keywords:
PCF-SPR biosensor, Skin cancer detection, Numerical Investigation, High-PerformanceReferences
Abdullah-Al-Shafi, M., & Sen, S. (2020). Design and analysis of a chemical sensing octagonal photonic crystal fiber (O-PCF) based optical sensor with high relative sensitivity for terahertz (THz) regime. Sensing and Bio-Sensing Research, 29. https://doi.org/10.1016/j.sbsr.2020.100372
Danlard, I., Mensah, I. O., & Akowuah, E. K. (2022). Design and numerical analysis of a fractal cladding PCF-based plasmonic sensor for refractive index, temperature, and magnetic field. Optik, 258. https://doi.org/10.1016/j.ijleo.2022.168893
Dash, J. N., & Jha, R. (2016). Highly Sensitive Side-Polished Birefringent PCF-Based SPR Sensor in near IR. Plasmonics, 11(6), 1505–1509. https://doi.org/10.1007/s11468-016-0203-8
Irawan, D., Azhar, A., & Ramadhan, K. (2022). High-Performance Compensation Dispersion with Apodization Chirped Fiber Bragg Grating for Fiber Communication System. Jurnal Penelitian Pendidikan IPA, 8(2), 992–999. https://doi.org/10.29303/jppipa.v8i2.1521
Irawan, D., Ramadhan, K., Saktioto, S., Fitmawati, F., Hanto, D., & Widiyatmoko, B. (2022a). Hexagonal two layers-photonics crystal fiber based on surface plasmon resonance with gold coating biosensor easy to fabricate. Indonesian Journal of Electrical Engineering and Computer Science, 28(1), 146. https://doi.org/10.11591/ijeecs.v28.i1.pp146-154
Irawan, D., Ramadhan, K., Saktioto, S., & Marwin, A. (2022). Performance comparison of Topas chirped fiber bragg grating sensor with tanh and gaussian apodization. Indonesian Journal of Electrical Engineering and Computer Science, 26(3), 1477–1485. https://doi.org/10.11591/ijeecs.v26.i3.pp1477-1485
Irawan, D., Ramadhan, K., Saktioto, T., Fitmawati, F., Hanto, D., & Widiyatmoko, B. (2022b). High-Performance of Star-Photonics Crystal Fiber Based on Surface Plasmon Resonance Sensor. Indian Journal of Pure & Applied Physics, 60(9), 727–733. https://doi.org/https://doi.org/10.56042/ijpap.v60i9.64411
Irawan D, S. T. (2014). Drug Delivery System Model using Optical Tweezer Spin Control. Journal of Biosensors & Bioelectronics, 05(03). https://doi.org/10.4172/2155-6210.1000159
Liu, Q., Ma, Z., Wu, Q., & Wang, W. (2020). The biochemical sensor based on liquid-core photonic crystal fiber filled with gold, silver and aluminum. Optics and Laser Technology, 130. https://doi.org/10.1016/j.optlastec.2020.106363
Mahfuz, M. Al, Mollah, M. A., Momota, M. R., Paul, A. K., Masud, A., Akter, S., & Hasan, M. R. (2019). Highly sensitive photonic crystal fiber plasmonic biosensor: Design and analysis. Optical Materials, 90, 315–321. https://doi.org/10.1016/j.optmat.2019.02.012
Mo, X., Lv, J., Liu, Q., Jiang, X., & Si, G. (2021). A magnetic field SPR sensor based on temperature self-reference. Sensors, 21(18). https://doi.org/10.3390/s21186130
Mollah, M. A., Yousufali, M., Ankan, I. M., Rahman, M. M., Sarker, H., & Chakrabarti, K. (2020). Twin core photonic crystal fiber refractive index sensor for early detection of blood cancer. Sensing and Bio-Sensing Research, 29. https://doi.org/10.1016/j.sbsr.2020.100344
Rahman, K. M. M., Alam, M. S., & Islam, M. A. (2021). Highly Sensitive Surface Plasmon Resonance Refractive Index Multi-Channel Sensor for Multi-Analyte Sensing. IEEE Sensors Journal, 21(24), 27422–27432. https://doi.org/10.1109/JSEN.2021.3126624
Rahman, M. T., Datto, S., & Sakib, M. N. (2021). Highly sensitive circular slotted gold-coated micro channel photonic crystal fiber based plasmonic biosensor. OSA Continuum, 4(6), 1808. https://doi.org/10.1364/osac.425279
Rakibul Islam, M., Iftekher, A. N. M., Rakibul Hasan, K., Nayen, M. J., & Bin Islam, S. (2020). Dual-polarized highly sensitive surface-plasmon-resonance-based chemical and biomolecular sensor. Applied Optics, 59(11), 3296. https://doi.org/10.1364/ao.383352
Ramadhan, K. (2020). Dispersi multi-layer pada inti serat optik moda tunggal. Seminar Nasional Fisika Universitas Riau V (SNFUR-5), 1–5.
Ramadhan, K., & Saktioto, T. (2021). Integrasi Chirping dan Apodisasi Bahan TOPAS untuk Peningkatan Kinerja Sensor Serat Kisi Bragg. Komunikasi Fisika Indonesia, 18(2), 111–123. https://doi.org/http://dx.doi.org/10.31258/jkfi.18.2.111-123
Ramola, A., Marwaha, A., & Singh, S. (2021). Design and investigation of a dedicated PCF SPR biosensor for CANCER exposure employing external sensing. Applied Physics A: Materials Science and Processing, 127(9). https://doi.org/10.1007/s00339-021-04785-2
Rifat, A. A., Mahdiraji, G. A., Ahmed, R., Chow, D. M., Sua, Y. M., Shee, Y. G., & Adikan, F. R. M. (2016). Copper-graphene-based photonic crystal fiber plasmonic biosensor. IEEE Photonics Journal, 8(1). https://doi.org/10.1109/JPHOT.2015.2510632
Sakib, N., Hassan, W., & Rahman, T. (2021). Performance study of a highly sensitive plasmonic sensor based on microstructure photonics using an outside detecting method. OSA Continuum, 4(10), 2615. https://doi.org/10.1364/osac.433758
Saktioto, T., Ramadhan, K., Soerbakti, Y., Irawan, D., & Okfalisa. (2021a). Apodization sensor performance for TOPAS fiber Bragg grating. Telkomnika, 19(6). https://doi.org/http://dx.doi.org/10.12928/telkomnika.v19i6.21669
Saktioto, T., Ramadhan, K., Soerbakti, Y., Irawan, D., & Okfalisa. (2021b). Integration of chirping and apodization of Topas materials for improving the performance of fiber Bragg grating sensors. Journal of Physics: Conference Series, 2049(1). https://doi.org/10.1088/1742-6596/2049/1/012001
Tsai, C. C. (2012). Water distribution in cancer and normal cells.
Wu, T., Shao, Y., Wang, Y., Cao, S., Cao, W., Zhang, F., Liao, C., He, J., Huang, Y., Hou, M., & Wang, Y. (2017). Surface plasmon resonance biosensor based on gold-coated side-polished hexagonal structure photonic crystal fiber. Optics Express, 25(17), 20313. https://doi.org/10.1364/oe.25.020313
Yan, X., Wang, Y., Cheng, T., & Li, S. (2021). Photonic crystal fiber spr liquid sensor based on elliptical detective channel. Micromachines, 12(4). https://doi.org/10.3390/mi12040408
Yaroslavsky, A. N., Patel, R., Salomatina, E., Li, C., Lin, C., Al-Arashi, M., & Neel, V. (2012). High-contrast mapping of basal cell carcinomas. Optics Letters, 37(4), 644. https://doi.org/10.1364/ol.37.000644
Yasli, A. (2021). Cancer Detection with Surface Plasmon Resonance-Based Photonic Crystal Fiber Biosensor. Plasmonics, 16(5), 1605–1612. https://doi.org/10.1007/s11468-021-01425-6
Yasli, A., & Ademgil, H. (2019). Effect of plasmonic materials on photonic crystal fiber based surface plasmon resonance sensors. Modern Physics Letters B, 33(13). https://doi.org/10.1142/S0217984919501574
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