Analysis of Gray Matter Volume (GMV) and White Matter Hyperintensity (WMH) in Ischemic Stroke Patients with Fluid Attenuated Inversion Recovery (FLAIR) Imaging
DOI:
10.29303/jppipa.v9i7.3377Published:
2023-07-25Issue:
Vol. 9 No. 7 (2023): JulyKeywords:
FLAIR, Gray matter volume, Hyperintensity, Magnetic resonance imaging, White matterResearch Articles
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Abstract
Stroke is a serious health problem faced by almost all over the world. The occurrence of ischemic stroke could affect the gray matter volume (GMV) in the human brain. In Magnetic Resonance imaging of an ischemic stroke with a FLAIR sequence, a white lesion known as the white matter hyperintensity (WMH) is often found. We studied correlation between gray matter volume (GMV) and white matter hyperintensity (WMH) in ischemic stroke patients using fluid attenuated inversion recovery (FLAIR) sequences. The MRI data were taken randomly from ten ischemic stroke patients (mean age 46.9 years) and ten normal patients (mean age 36.8 years). FLAIR axial image parameters, i.e. TE (time echo), TR (time repetition), and TI (time inversion) were analyzed. The results reveal that the TE and TR values in FLAIR images of normal and ischemic stroke patients are classified as long TE (more than 70 ms), long TRÂ (more than 1500 ms) and long TI (more than 1700 ms). The mean GMV of ischemic stroke patients (1.371 cm3) is smaller than the GMV of normal patients (2.267 cm3). This is related to the presence of white matter hyperintensity (WMH) in ischemic stroke patients
References
Ahmed Mesrur, H., & David Mark, Y. (2018). Susceptibility Weighted Imaging: Clinical Applications And Future Directions. World Journal Of Radiology, 10(4). Https://Doi.Org/10.4329/Wjr.V10.I4.30
Alam, D. Y. (2020). Analisis Grey Matter Volume Pada Pasien Stroke Iskemik Dengan Diffusion Weighted Magnetic Resonance Imaging Tesis. Universitas Brawijaya.
Amin, M. A. (2017). Klasifikasi Kelompok Umur Manusia Berdasarkan Analisis Dimensi Fraktal Box Counting Dari Citra Wajah Dengan Deteksi Tepi Canny. MATHunesa: Jurnal Ilmiah Matematika, 5(2). Retrieved from https://ejournal.unesa.ac.id/index.php/mathunesa/article/view/19398
Badan Penelitian Dan Pengembangan KEMENKES RI. (2018). Hasil Riskesdas Tahun 2018 (P. 220) [Siwabessy_02112018]. Kementrian Kesehatan RI. Retrieved from https://kesmas.kemkes.go.id/assets/upload/dir_519d41d8cd98f00/files/hasil-riskesdas-2018_1274.pdf
Brown, R. (2023). Stroke—Symptoms And Causes. Mayo Clinic. Retrieved from https://www.mayoclinic.org/diseases-conditions/stroke/symptoms-causes/syc-20350113
Cho, A.-H., Kim, H.-R., Kim, W., & Yang, D. W. (2015). White Matter Hyperintensity In Ischemic Stroke Patients: It May Regress Over Time. Journal Of Stroke, 17(1), 60. https://doi.org/10.5853/jos.2015.17.1.60
Diao, Q., Liu, J., Wang, C., Cao, C., Guo, J., Han, T., Cheng, J., Zhang, X., & Yu, C. (2017). Gray Matter Volume Changes In Chronic Subcortical Stroke: A Cross-Sectional Study. Neuroimage: Clinical, 14, 679–684. https://doi.org/10.1016/j.nicl.2017.01.031
Grover, V. P. B., Tognarelli, J. M., Crossey, M. M. E., Cox, I. J., Taylor-Robinson, S. D., & Mcphail, M. J. W. (2015). Magnetic Resonance Imaging: Principles And Techniques: Lessons For Clinicians. Journal Of Clinical And Experimental Hepatology, 5(3), 246. https://doi.org/10.1016/j.jceh.2015.08.001
IMAIOS SAS. (2022). NMR Signal And MRI Contrast: Signal Weighting And Sequences Parameters | E-MRI. IMAIOS. Retrieved from https://www.imaios.com/en/e-mri/nmr-signal-and-mri-contrast/signal-weighting-and-sequences-parameters
Indrawati, L., Sari, W., & Dewi, C. S. (2016). Stroke, Cegah Dan Obati Sendiri (1st Ed.). Penebar Plus.
Kemenkes Republik Indonesia. (2019). Hari Stroke Sedunia 2019: Otak Sehat, SDM Unggul. Direktorat P2PTM. Retrieved from http://p2ptm.kemkes.go.id/artikel-sehat/hari-stroke-sedunia-2019-otak-sehat-sdm-unggul
Kiselev, V. G., & Novikov, D. S. (2018). Transverse NMR Relaxation In Biological Tissues. Neuroimage, 182, 149–168. https://doi.org/10.1016/j.neuroimage.2018.06.002
Kwok, W. E. (2022). Basic Principles Of And Practical Guide To Clinical MRI Radiofrequency Coils. Radiographics. https://doi.org/10.1148/rg.210110
Lutvia, H. (2016). Pengaruh Variasi Waktu Pembalik (Time Inversion) Terhadap Citra Coronal Studi Pemeriksaan MRI Kepala [Universitas Airlangga]. Retrieved from https://repository.unair.ac.id/54178/13/mpf_15-16_lut_p.pdf
Mackenzie, R. (2023, February). Gray Matter Vs White Matter. Neuroscience From Technology Networks. Retrieved from http://www.technologynetworks.com/neuroscience/articles/gray-matter-vs-white-matter-322973
Mcrobbie, D. W. (2020). Essentials Of MRI Safety. John Wiley & Sons.
Mercadante, A. A., & Tadi, P. (2022). Neuroanatomy, Gray Matter. In Statpearls [Internet]. Statpearls Publishing. Retrieved from https://www.ncbi.nlm.nih.gov/books/nbk553239/
Merino, J. G. (2019). White Matter Hyperintensities On Magnetic Resonance Imaging: What Is A Clinician To Do? Mayo Clinic Proceedings, 94(3), 380–382. https://doi.org/10.1016/j.mayocp.2019.01.016
Moghadam R, N., Rahimdel, A., Shanbehzadeh, T., & Fallah, R. (2017). Comparison Of Diffuse Weighted Imaging And Fluid Attenuation Inversion Recovery Sequences Of MRI In Brain Multiple Sclerosis Plaques Detection. Iranjchildneurol, 11, 8. Retrieved from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5329755/
Phipps, M. S., & Cronin, C. A. (2020). Management Of Acute Ischemic Stroke. BMJ, 368. https://doi.org/10.1136/bmj.l6983
Powers, S. J. (2021). MRI Physics: Tech To Tech Explanations. John Wiley & Sons.
Setiawan, A. N., Suroso, A., & Rosyid. (2016). Pengaruh Variasi Time Echo (Te) Terhadap Citra Fluid-Attenuated Inversion Recovery (FLAIR) MRI Otak. Semarang: Prodi DIV T. Radiodiagnostik dan Radioterapi Semarang Poltekkes Kemenkes Semarang. Retrieved from https://www.researchgate.net/publication/322095397_pengaruh_variasi_time_echo_te_terhadap_citra_fluid-attenuated_inversion_recovery_flair_mri_otak/citations
Wardlaw, J. M., Hernandez, M., & Munos Maniaga, S. (2015). What Are White Matter Hyperintensities Made Of? Relevance To Vascular Cognitive Impairment. Journal Of The American Heart Association, 4(6), 19. https://doi.org/10.1161/jaha.114.001140
WHO. (2020). The Top 10 Causes Of Death. World Health Organization. Retrieved from https://www.who.int/news-room/fact-sheets/detail/the-top-10-causes-of-death
Yueniwati, Y. (2016). Pencitraan Pada Stroke (1st Ed.). Universitas Brawijaya Press.
Author Biographies
Ade Lina Nur Fadlilah, Universitas Brawijaya
Johan Andoyo Effendi Noor, Universitas Brawijaya
Yuyun Yueniwati, Universitas Islam Negeri Maulana Malik Ibrahim
Karimah, Universitas Brawijaya
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Copyright (c) 2023 Ade Lina Nur Fadlilah, Johan Andoyo Effendi Noor, Yuyun Yueniwati, Karimah
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