Antidiabetic Power of Belalai gajah Plant (Clinacanthus nutans)

Authors

Ariesta Albriyanti , Nur Annisa , Ananda Dwi Putri , Ruqiah Ganda Putri Panjaitan

DOI:

10.29303/jppipa.v9iSpecialIssue.4477

Published:

2023-12-31

Issue:

Vol. 9 No. SpecialIssue (2023): UNRAM journals and research based on science education, science applications towards a golden Indonesia 2045

Keywords:

Belalai gajah (Clinacanthus nutans), Blood glucose, Diabetes mellitus, MDA levels, Pancreatic histopathology

Research Articles

Downloads

How to Cite

Albriyanti, A., Annisa, N., Putri, A. D., & Panjaitan, R. G. P. (2023). Antidiabetic Power of Belalai gajah Plant (Clinacanthus nutans). Jurnal Penelitian Pendidikan IPA, 9(SpecialIssue), 1354–1362. https://doi.org/10.29303/jppipa.v9iSpecialIssue.4477

Downloads

Download data is not yet available.

Metrics

Metrics Loading ...

Abstract

This study aims to determine the decrease in rat blood glucose levels, MDA levels, and the histopathological description of pancreas after giving ethanol extract of belalai gajah plant. This study used 25 rats, grouped into 5, namely normal control, negative control (CMC-Na 0.5% dose 2 mL/200 g b.w), positive control (glibenclamide dose 0.09 mg /200 g b.w), belalai gajah plant ethanol extract (dose 30 mg/200 g b.w., and 60 mg/200 g b.w). Prior to treatment, the rats were induced into diabetes with streptozotocin-nicotinamide. The content of belalai gajah plant was tested phytochemically and antidiabetic. Potential of belalai gajah plant was tested by induction for 14 days. The results showed that ethanol extract of belalai gajah plant contained alkaloids, flavonoids, steroids, terpenoids, and phenolics. The decrease in blood glucose and MDA levels in the group given the ethanol extract of belalai gajah plant at dose of 60 mg/200 g b.w. was the same as the dose of glibenclamide 0.09 mg/200 g b.w. The results of histopathological of pancreas showed that the ethanol extract of belalai gajah plant at dose of 60 mg/200 g b.w. could improve the structure of Langerhans islets in the pancreas of diabetic rats.

References

Abdullah, N., & Kasim, K. F. (2017). In-vitro antidiabetic activity of Clinacanthus nutans extracts. International Journal Pharmacology Phytochemistry and Ethnomedicine Research, 9(6), 846–852. https://doi.org/10.25258/phyto.v9i6.8189.

Anggi, V., Safitra, D., Tandi, J., & Pakaya, D. (2022). Uji efek ekstrak etanol daun jeruk nipis terhadap gambaran histopatologi ginjal tikus model diabetes. Farmakologika Jurnal Farmasi, 19(1), 100–112. Retrieved from https://jfarma.org/index.php/farmakologika/article/view/397.

Anggraeny, E. N., Cahyani, I. M., Retnaningsih, C., Ananingsih, V. K., Prahasiwi, M. S., Nugraheni, B., & Sari, A. D. N. I. (2021). The effect of aqueous fraction of Clinacanthus nutans (Burm.F.) extract microcapsules on rat blood glucose level. Indonesian Journal of Pharmacy, 32(1), 126–131. https://doi.org/10.22146/ijp.1230

Arullappan, S., Prabu, R., Naadeirmuthu, T., & Clara, C. K. (2014). In vitro screening of cytotoxic, antimicrobial and antioxidant activities of Clinacanthus nutans (Acanthaceae) leaf extracts. Tropical Journal of Pharmaceutical Research, 13(9), 1455–1461. https://doi.org/10.4314/tjpr.v13i9.11.

Bahagia, W., Kurniawaty, E., & Mustafa, S. (2018). Potensi ekstrak buah pare (Momordhica charantia) sebagai penurun kadar glukosa darah: Manfaat di balik rasa pahit. Majority, 7(2), 177–181. Retrieved from https://juke.kedokteran.unila.ac.id/index.php/majority/article/view/1871.

Barky, A. R. E., Hussein, S. A., Eldeen, A. A. E. A., Hafez, Y. A., & Mohamed, T. M. (2017). Saponins and their potential role in diabetes mellitus. Diabetes Management, 7(1), 148– 158. Retrieved from https://www.researchgate.net/publication/315114576.

Dewinta, R. M., Mukono, I. S., & Mustika, A. (2020). Pengaruh pemberian ekstrak dandang gendis (Clinacanthus nutans) terhadap kadar glukosa darah pada tikus wistar model diabetes mellitus. Jurnal Medik Veterine, 3(1), 76–81. https://doi.org/10.20473/jmv.vol3.iss1.2020.76-81.

Dhurhania, C. E., & Novianto, A. (2018). Uji kandungan fenolik total dan pengaruhnya terhadap aktivitas antioksidan dari berbagai bentuk sediaan sarang semut (Myrmecodia pendens. Jurnal Farmasi Dan Ilmu Kefarmasian Indonesia, 5(2), 62–68. https://doi.org/10.20473/jfiki.v5i22018.62-68.

Fatimah, R. N. (2015). Diabetes mellitus tipe 2. Jurnal Majority, 4(5), 86–90. Retrieved from https://juke.kedokteran.unila.ac.id/index.php/majority/article/view/615.

Febrina, L., Helmi., & Rijai., L. (2016). Profil kadar malondialdehida, glukosa, dan kolesterol pada tikus putih yang terpapar asap rokok. Journal of Tropical Pharmacy and Chemistry, 3(4), 277–282. https://doi.org/10.25026/jtpc.v3i4.115.

Ghasemi, A., Khalifi, S., & Jedi, S. (2014). Streptozotocin-nicotinamide-induced rat model of type 2 diabetes. Acta Physiologica Hungarica, 101(4), 107–190. https://doi.org/10.1556/aphysiol.101.2014.4.2.

Hairunnisa., S., I., & Gozali, D. (2019). Ko-kristal: Nikotinamid sebagai koformer. Jurnal Ilmiah Farmako Bahari, 10(2), 113–122. https://doi.org/10.52434/jfb.v10i2.652.

Harborne, J. B. (1987). Metode fitokimia: Penuntun cara modern menganalisis tumbuhan. Bandung: ITB.

Hidayat, S. N., & Setyaningsih, E. (2021). Kulit batang kayu manis (Cinnamomum burmanii) ditinjau dari metode ekstraksi dan dosis efektif terhadap diabetes (literatur review. Symbiotic: Journal of Biological Education, 2(2), 40–54. https://doi.org/10.32939/symbiotic.v2i2.19.

Kooti, W., Farokhipour, M., Asadzadeh, Z., Larky, D. A., & Samani, M. A. (2016). The role of medicinal plants in the treatment of diabetes: A systematic review. Electron Physician, 8(1), 1832–1842. https://doi.org/10.19082%2F1832.

Kumari, M., & Jain, S. (2012). Tannins: An antinutrient with positive effect to manage diabetes. Journal Recent Science Research, 1(12), 1–8. Retrieved from http://www.isca.in/rjrs/archive/v1/i12/14.ISCA-RJRS-2012-113.php.

Larantukan, S. V. M., Setiasih, N. L. E., & Widyastuti, S. K. (2014). Pemberian ekstrak etanol kulit batang kelor glukosa darah tikus hiperglikemia. Indonesia Medicus Veterinus, 3(4), 292–299. Retrieved from https://ojs.unud.ac.id/index.php/imv/article/view/11151.

Mai, C. W., Yap, K. S. I., Kho, M. T., Ismail, N. H., Yusoff, K., Shaari, K., Chin, S. Y., & Lim, E. S. H. (2016). Mechanisms underlying the anti-inflammatory effects of Clinacanthus nutans Lindau extracts: Inhibition of cytokine production and toll-like receptor-4 activation. Frontiers in Pharmacology, 7(7), 1–11. https://doi.org/10.3389/fphar.2016.00007.

Maryam, F., Subehan., & Musthainah, L. (2020). Isolasi dan karakterisasi senyawa steroid dari ekstrak biji mahoni (Swietenia mahagoni Jacq. Jurnal Fitofarmaka Indonesia, 7(2), 6–11. https://doi.org/10.33096/jffi.v7i2.647.

Nizar, R. Z. E., Andriane, Y., & Trisnadi, S. (2020). Scoping Review: Efek daun belalai gajah (Clinacanthus nutans) terhadap penurunan kadar glukosa darah pada tikus model diabetes. Bandung Conference Series: Medical Science, 2(1), 1–10. https://doi.org/10.29313/bcsms.v2i1.1749.

Panjaitan, R. G. P., & Astuti, A. (2021). Antidiabetic activity of the leaf extract of Eurycoma Longifolia Jack. in streptozotocin-nicotinamide induced diabetic model. Pharmacognosy Journal, 13(6), 1582–1588. https://doi.org/10.5530/pj.2021.13.203.

Panjaitan, R. G. P., Handharyani, E., Chairul., & Manalu, W. (2013). Hepatoprotective of Eurycoma longifolia Jack. Roots. Indian Journal of Traditional Knowledge, 12(2), 225– 230. Retrieved from https://nopr.niscpr.res.in/bitstream/123456789/16865/1/IJTK 12%282%29 225-230.pdf.

Panjaitan, R. G. P., & Novitasari. (2021). Anti-diabetic activity of the red dragon fruit peel (Hylocereus polyrhizus) in ethanol extract against diabetic rats. Pharmacognosy Journal, 13(5), 1079–1085. https://doi.org/10.5530/pj.2021.13.140.

Prameswari, O. M., & Widjanarko, S. B. (2014). Uji efek ekstrak air daun pandan wangi terhadap penurunan kadar glukosa darah dan histopatologi tikus diabetes mellitus. Jurnal Pangan Dan Agroindustri, 2(2), 16–27. Retrieved from https://jpa.ub.ac.id/index.php/jpa/article/view/33.

Prawitasari, D. S. (2019). Diabetes melitus dan antioksidan. Jurnal Kesehatan Dan Kedokteran, 1(1), 48–52. https://doi.org/10.24123/kesdok.V1i1.2496.

Puspitasari, V., & Choerunisa, N. (2021). Kajian sistematik: Efek antidiabetes buah pare (Momordica charantia Linn.) terhadap kadar glukosa darah pada tikus yang diinduksi aloksan. Generics: Journal of Research in Pharmacy, 1(2), 18–27. https://doi.org/10.14710/genres.v1i2.11052.

Retnaningsih, C., Ananingsih, V. K., Meiliana., A., E.N., C., I.M., N., B., & Efendi, R. (2019). The effect of Clinacanthus nutans (Burm.f.) Lindau water fraction addition on hypoglycemia. International Conference on Food Science & Technology, 292, 1–9. https://doi.org/10.1088/1755-1315/292/1/012032

Safitri, Y., & Nurhayati, I. K. A. (2019). Pengaruh bengkuang (Pachyrhizus erosus) terhadap kadar glukosa darah pada penderita diabetes mellitus tipe II usia 40-50 tahun di Kelurahan Bangkinang Wilayah Kerja Puskesmas Bangkinang Kota tahun 2018. Jurnal Ners Indonesia, 3(1), 69–81. https://doi.org/10.31004/prepotif.v2i2.53.

Salimi, Y. K., Hasan, A. S., & Botutihe, D. N. (2021). Sintesis dan karakterisasi Carboxymethyl Cellulose Sodium (Na-CMC) dari selulosa eceng gondok (Eichhornia crassipes) dengan media reaksi etanol isobutanol. Jambura Journal of Chemistry, 3(1), 1–11. https://doi.org/10.34312/jambchem.v3i1.9288.

Samsuri, D. A., Samsuri., & Kendran, A. A. S. (2020). Kadar glukosa darah tikus putih (Rattus norvegicus) yang diberikan ragi tape. Indonesia Medicus Veterinus, 9(4), 531–539. https://doi.org/10.19087/imv.2020.9.4.531.

Saputra, N. T., Suartha, I. N., & Dharmayudha, A. A. G. O. (2018). Agen diabetagonik streptozotocin untuk membuat tikus putih jantan diabetes mellitus. Buletin Veteriner Udayana, 10(2), 116–121. https://doi.org/10.24843/bulvet.2018.v10.i02.p02.

Saragih, D. E., & Arsita, E. V. (2019). Kandungan fitokimia Zanthoxylum acanthopodium dan potensinya sebagai tanaman obat di wilayah Toba Samosir dan Tapanuli Utara, Sumatera Utara. Prosiding Seminar Nasional Masyarakat Biodiversitas Indonesia, 5(1), 71–76. https://doi.org/10.13057/psnmbi/m050114.

Sinulingga, S., Subandrate., & Safyudin. (2020). Uji fitokimia dan potensi antidiabetes fraksi etanol air daun benalu kersen (Dendrophtoe petandra (L) Miq. Jurnal Kedokteran Dan Kesehatan, 16(1), 76–83. https://doi.org/10.24853/jkk.16.1.76-83.

Surbekti, C., Ginting, P. A. B., Abadi, H., & Duha, Y. (2022). Uji aktivitas antidiabetes ekstrak etanol daun cengkeh (Syzygium aromaticum) terhadap tikus putih jantan dan gambaran histologi pankreas. Jurnal Farmasi Indonesia, 19(1), 2302–4291. https://doi.org/10.31001/jfi.v19i1.1375.

Sutaryono., A., S.D., & Hidayati, N. (2018). Pengaruh pemberian campuran bee pollen, rimpang kencur, kunyit dan biji pinang terhadap penurunan kadar malondialdehida (MDA) pada tikus wistar pasca paparan streptozotocin. The 3rd Universty Research Colloquium, 496–504. Retrieved from http://hdl.handle.net/11617/6820.

Viena, V., Yunita, I., Irhamni., S., & Ernilasari. (2018). Biodiversitas tumbuhan obat oleh masyarakat Gampong Pulo Seunong Kecamatan Tangse Kabupaten Pidie. Journal of Islamic Science and Technology, 4(1), 89–100. https://doi.org/10.22373/ekw.v4i1.3027.

Vinayagam, R., & Xu, B. (2015). Antidiabetic properties of dietary flavonoids: A cellular mechanism review. Nutrition Metabolism, 12(1), 60–79. https://doi.org/10.1186/s12986-015-0057-7.

Widyastuti, S., Usman, S., & Rahayu, D. (2022). Uji efektivitas antidiabetik kombinasi ekstrak daun senggani (Melastomapolyanthum Bl.) dan glibenklamid dalam menurunkan kadar glukosa darah pada mencit (Mus musculus. Jurnal Sains Dan Kesehatan, 4(3), 262–267. https://doi.org/10.25026/jsk.v4i3.1028.

Zaetun, S., Dewi, L. B. K., Wiadnya, I. B. R., & Srigede, L. (2017). Profil kadar MDA (Malondialdehide) sebagai penanda kerusakan seluler akibat radikal bebas pada tikus yang diberikan air beroksigen. Jurnal Analis Medika Bio Sains, 4(2), 63–68. https://doi.org/10.32807/jambs.v4i2.87.

Author Biographies

Ariesta Albriyanti, Program Studi Pendidikan Biologi, FKIP, Universitas Tanjungpura

Nur Annisa, Program Studi Pendidikan Biologi, FKIP, Universitas Tanjungpura

Ananda Dwi Putri, Program Studi Pendidikan Biologi, FKIP, Universitas Tanjungpura

Ruqiah Ganda Putri Panjaitan, Universitas Tanjungpura

License

Copyright (c) 2023 Ariesta Albriyanti, Nur Annisa, Ananda Dwi Putri, Ruqiah Ganda Putri Panjaitan

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Authors who publish with Jurnal Penelitian Pendidikan IPA, agree to the following terms:

  1. Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution 4.0 International License (CC-BY License). This license allows authors to use all articles, data sets, graphics, and appendices in data mining applications, search engines, web sites, blogs, and other platforms by providing an appropriate reference. The journal allows the author(s) to hold the copyright without restrictions and will retain publishing rights without restrictions.
  2. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in Jurnal Penelitian Pendidikan IPA.
  3. Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).