Formulation and Activity Test of Red Algae Extract Gel (Eucheuma cottonii) Against Propionibacterium acnes Bacteria

Authors

Nurhikma Awaluddin , Andi Meinar Dwi Rantisari Thayeb , Andi Ulfiana Utari , Akbar Awaluddin , Nur Pebrianti Caronge

DOI:

10.29303/jppipa.v9i11.5513

Published:

2023-11-25

Issue:

Vol. 9 No. 11 (2023): November

Keywords:

Acne, Antibacterial, Propionibacterium acnes, Red algae (Eucheuma cottonii)

Research Articles

Downloads

How to Cite

Awaluddin, N., Thayeb, A. M. D. R. ., Utari, A. U. ., Awaluddin, A. ., & Caronge, N. P. . (2023). Formulation and Activity Test of Red Algae Extract Gel (Eucheuma cottonii) Against Propionibacterium acnes Bacteria. Jurnal Penelitian Pendidikan IPA, 9(11), 10356–10363. https://doi.org/10.29303/jppipa.v9i11.5513
Crossref
Scopus
Google Scholar
Europe PMC

Downloads

Download data is not yet available.

Metrics

Metrics Loading ...

Abstract

Flavanoids are one of the many compounds in phenols that can denature bacterial cell membrane proteins, thus inhibiting cell growth. The purpose of this study was to formulate an anti-acne gel for the ethanolic extract of red algae (Eucheuma cottonii) and to test its antimicrobial activity against Propionibacterium acnes. The method used is laboratory research design by making antiacne gel preparations of red algae extract with concentrations of 1%, 3%, 5% and testing the antimicrobial activity with the agar diffusion method using wells on MHA media which is incubated for 1x24 hours. The results of the evaluation of the gel preparation before and after the cycling test met the requirements of organoleptic, homogeneity, pH, viscosity, and dispersibility where each formula was stable in the gel preparation. The results showed that red algae extract (Eucheuma cottonii) could be formulated and was stable in the form of an anti-acne gel and had antibacterial activity. In formula I with a concentration of 1% the inhibition zone formed was 36.33 mm, in formula II with a concentration of 3% the inhibition zone formed was 38.79 mm and in formula III with a concentration of 5% the inhibition zone formed was 34.27 mm. So which has optimal antibacterial activity against Propionibacterium acnes is formula II with a concentration of 3% and an area of ​​inhibition zone of 38.79 mm.

References

Afriyanti, R. N. (2015). Akne Vulgaris Pada Remaja. Medical Faculty of Lampung University, 4(6), 102–109. Retrieved from https://juke.kedokteran.unila.ac.id/index.php/majority/article/view/616

Amaranggana, L., & Wathoni, N. (2017). Manfaat Alga Merah (Rhodophyta) Sebagai Sumber Obat dari Bahan Alam. Farmasetika.Com (Online), 2(1), 16. https://doi.org/10.24198/farmasetika.v2i1.13203

Aqsha, A. C., N. R., S., Dea A., P., Nadya, A., Stefany V., A., Ikhfan T., J., Siti Halima, H., Novi Ayu, A. S., S., A., C., D. G., & Rif’atul I., E. (2016). Profil Pemilihan Dan Penggunaan Produk Antijerawat Yang Tepat Pada Mahasiswa. Jurnal Farmasi Komunitas, 3(1), 18–22. Retrieved from https://journal.unair.ac.id/download-fullpapers-jfk1dbe4e3b7a2full.pdf

Ardiati, K. N. (2018). Formulasi Sediaan Gel Ekstrak Daun Lidah Mertua (Sansivieria trifasciata) Dengan Gelling Sgent Karbopol - 934 Dan Uji Aktivitas Antibakteri Secara In Vitro Terhadap Staphylococcus epidermidis. Universitas Muhammadiyah Surakarta.

Dwyana, Z., & Johannes, E. (2012). Uji Efektivitas Ekstrak Alga Merah Euchema cottonii sebagai Antibakteri terhadap Bakteri Patogen. Jurnal Ilmu Kefarmasian, 7(1), 1–7. Retrieved from https://core.ac.uk/reader/25489644

Fadillah, N., Pebrianti, N., & Mukkun. (2020). Skrining Fitokimia. Makassar: Universitas Mega Rezky.

Fujiastuti, T., & Sugihartini, N. (2015). Sifat Fisik dan Daya Iritasi Gel Ekstrak Etanol Herba Pegagan (Centella asiatica L. Urban) Dengan Variasi Jenis Gelling Agent. Pharmacy, 12(01), 87–90. Retrieved from https://jurnalnasional.ump.ac.id/index.php/PHARMACY/article/view/810

Haryati, S. D., Darmawati, S., & Wilson, W. (2017). Perbandingan Efek Ekstrak Buah Alpukat (Persea americana Mill) terhadap Pertumbuhan Bakteri Pseudomonas aeruginosa dengan Metode Disk dan Sumuran. Prosiding Seminar Nasional Publikasi Hasil-Hasil Penelitian Dan Pengabdian Masyarakat “Implementasi Penelitian Dan Pengabdian Masyarakat Untuk Peningkatan Kekayaan Intelektual,†348–352. Retrieved from https://jurnal.unimus.ac.id/index.php/psn12012010/article/view/2886

Indarto, I., Narulita, W., Anggoro, B. S., & Novitasari, A. (2019). Aktivitas Antibakteri Ekstrak Daun Binahong Terhadap Propionibacterium Acnes. Biosfer: Jurnal Tadris Biologi, 10(1), 67–78. https://doi.org/10.24042/biosfer.v10i1.4102

Lingga, A. R., Pato, U., & Rossi, E. (2016). Uji Antibakteri Ekstrak Batang Kecombrang (Nicolaia speciosa Horan) terhadap Staphylococcus aureus dan Escherichia coli. JOM Faperta, 2(2), 1–15. Retrieved from https://www.neliti.com/publications/186658/uji-antibakteri-ekstrak-batang-kecombrang-nicolaia-speciosa-horan-terhadap-staph

Numberi, A. M. (2020). Uji Stabilitas Fisik Sediaan Masker Gel dari Ekstrak Alga Merah (Poryphyra sp). Majalah Farmasetika, 5(1), 1–17. https://doi.org/10.24198/mfarmasetika.v5i1.24066

Pratasik, M. C. M., Yamlean, P. V. Y., & Wiyono, W. I. (2019). Formulasi dan Uji Stabilitas Fisik Sediaan Krim Ekstrak Etanol Daun Sesewanua (Clerodendron squamatum Vahl.). Pharmacon, 8(2), 261. https://doi.org/10.35799/pha.8.2019.29289

Pringgenies, D., Setyati, W. A., Wibowo, D. S., & Djunaedi, A. (2020). Aktivitas Antibakteri Ekstrak Jeruju Acanthus ilicifolius terhadap Bakteri Multi Drug Resistant. Jurnal Kelautan Tropis, 23(2), 145–156. https://doi.org/10.14710/jkt.v23i2.5398

Rahmatullah, S., Agustin, W., & Kurnia, N. (2020). Formulasi Dan Evaluasi Sediaan Gel Hand Sanitizer Sebagai Antiseptik Tangan Dengan Variasi Basis Karbopol 940 Dan Tea Chmk Pharmaceutical Scientific Journal. Chmk Pharmaceutical Scientific Journal, 3(September 2020), 189–194. Retrieved from https://cyber-chmk.net/ojs/index.php/farmasi/article/download/847/300

Sayuti, N. A. (2015). Formulasi dan Uji Stabilitas Fisik Sediaan Gel Ekstrak Daun Ketepeng Cina (Cassia alata L.). Jurnal Kefarmasian Indonesia, 5(2). https://doi.org/10.22435/jki.v5i2.4401.74-82

Siahaan, S. P. L., Isnindar, & Rialita, A. (2013). Uji Aktivitas Antibakteri Infusa Biji Buah Langsat (Lansium Domesticum Cor.) terhadap Salmonella Typhi. Jurnal Mahasiswa PSPD FK Universitas Tanjungpura, 1(1). Retrieved from https://jurnal.untan.ac.id/index.php/jfk/article/viewFile/6340/6517

Sibero, H. T., Wayan, I., Putra, A., & Anggraini, D. I. (2019). Tatalaksana Terkini Acne Vulgaris. JK Unila, 3(2), 313. Retrieved from http://repository.lppm.unila.ac.id/43373/

Wahyuni, S. (2016). Uji Aktivitas Antibakteri Alga Merah Eucheuma spinosum Asal Perairan Galesong Kabupaten Takalar Terhadap Bakteri Salmonella thypi dan Bacillus subtilis I. Nature Methods, 7(6), 2016. Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/26849997%0Ahttp://doi.wiley.com/10.1111/jne.12374

Wijayati, N., Astutiningsih, C., Mulyati, S., & Artikel, I. (2014). Transformasi α-Pinena dengan Bakteri Pseudomonas aeruginosa ATCC 25923. Biosaintifika: Journal of Biology & Biology Education, 6(1), 24–28. https://doi.org/10.15294/biosaintifika.v6i1.2931

Winastri, N. L. A. P., Muliasari, H., & Hidayati, E. (2020). Aktivitas Antibakteri Air Perasan Dan Rebusan Daun Calincing (Oxalis corniculata L.) TERHADAP Streptococcus mutans. Berita Biologi, 19(2). https://doi.org/10.14203/beritabiologi.v19i2.3786

Zahrah, H., Mustika, A., & Debora, K. (2019). Aktivitas Antibakteri dan Perubahan Morfologi dari Propionibacterium Acnes Setelah Pemberian Ekstrak Curcuma Xanthorrhiza. Jurnal Biosains Pascasarjana, 20(3), 160. https://doi.org/10.20473/jbp.v20i3.2018.160-169

Author Biographies

Nurhikma Awaluddin, Megarezky University, Makassar

Andi Meinar Dwi Rantisari Thayeb, Health Polytechnic, Ministry of Health, Makassar

Andi Ulfiana Utari, College of Pharmaceutical Sciences, Makassar

Akbar Awaluddin, Health Polytechnic, Ministry of Health, Makassar

Nur Pebrianti Caronge, Megarezky University, Makassar

License

Copyright (c) 2023 Nurhikma Awaluddin, Andi Meinar Dwi Rantisari Thayeb, Andi Ulfiana Utari, Akbar Awaluddin, Nur Pebrianti Caronge

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Authors who publish with Jurnal Penelitian Pendidikan IPA, agree to the following terms:

  1. Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution 4.0 International License (CC-BY License). This license allows authors to use all articles, data sets, graphics, and appendices in data mining applications, search engines, web sites, blogs, and other platforms by providing an appropriate reference. The journal allows the author(s) to hold the copyright without restrictions and will retain publishing rights without restrictions.
  2. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in Jurnal Penelitian Pendidikan IPA.
  3. Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).