Content of Banten Leaf Extract (Lannea Coromandelica (Houtt.) Merr.) Traditional Medicine of Lombok as an Antipyretic in Mice (Mus Musculus)
DOI:
10.29303/jppipa.v10i4.6756Published:
2024-04-25Downloads
Abstract
The Sasak tribe, who are the indigenous inhabitants of Lombok Island, use banten (Lannea coromandelica (Houtt.) Merr.) leaves as a medicinal plant to reduce fever. Fever is a physiological response to infection, characterized by a body temperature above the normal range of approximately ± 37 ℃. If left untreated, fever can cause dehydration, lack of oxygen, nerve damage, dizziness, decreased appetite, weakness, and muscle pain. To minimize these effects, antipyretics such as paracetamol can be used. However, prolonged or excessive use of paracetamol can cause hepatotoxicity, hepatic necrosis, renal tubular necrosis, and hypoglycemic coma. Therefore, it is necessary to develop alternative herbal medicines to treat fever. The aim of this study is to determine the content and antipyretic effect of banten leaf extract, which was obtained through ethanol extraction. The antipyretic ability test utilized five groups: the negative control group, positive control group, and test groups receiving doses of 1 mg/25gBB, 3 mg/25gBB, and 10 mg/25gBB of ethanol extract of banten leaves. Fever induction was induced using the DPT-HB vaccine. The study found that the ethanol extract of banten leaves contained flavonoids (572.38 mg QE/gram extract), phenols (200.82 mg GAE/gram extract), and antioxidants (2.5063 mg GAE/gram extract with DPPH). The percentage of antioxidant inhibition in banten leaves between 9.68-47.16 %. Additionally, all test groups of the ethanol extract of banten leaves exhibited antipyretic activity. The antipyretic effect of the 3 mg/25gBB dose was equivalent to that of paracetamol. Similarly, the antipyretic effect of the 10 mg/25gBB dose was almost identical to that of paracetamol at 5 hours after treatment.
Keywords:
Antipyretic, Banten leaves (L. coromandelica), DPT-HB vaccine, Fever, Traditional medicineReferences
Antipyretic and Anti-Nociceptive Effects of Methanol Extract of Leaves of Fimbristylis miliacea in Mice Model. Journal of Ethnopharmacology, 243, 112080. https://doi.org/
1016/j.jep.2019.112080
Saleem, U., Ahmad, B., Ahmad, M., Hussain, K., & Bukhari, N. I. (2015). Anti-Nociceptive, Anti-Inflammatory and Anti-Pyretic Activities of Latex and Leaves Methanol Extract of Euphorbia helioscopia. Asian Pacific Journal of Tropical Disease, 5(4), 322–328. https://doi.org/10.1016/S2222-1808(14)60791-X
Sambou, C. N. (2022). Tanaman Herbal yang Memiliki Aktivitas Antipiretik. Majalah INFO Sains, 3(2). https://doi.org/10.55724/jis.v3i2.57
Selvaraj, D., Kotapadu, A., Sampurna, B., & Krishnan, C. (2015). Detection of Active Constituents from the Leaf Extract of Lannea Coromandelica by Gc-Ms Testing and Assessment of Its Pharmacological Activity. International Journal of Pharmaceutical Sciences and Research, 6(3), 1217-1221. Retrieved from https://ijpsr.com/?action=download_pdf&p
ostid=19285
Suharyanto, S., & Hayati, T. N. (2021). Penetapan Kadar Flavonoid Total Ekstrak Buah Gambas (Luffa acutangula (L.) Roxb.) dengan Metode Spektrofotometri UV-Vis. Pharmacon: Jurnal Farmasi Indonesia, 18(1). https://doi.
org/10.23917/pharmacon.v18i01.10916
Sultana, S., Asif, H. M., Akhtar, N., & Ahmad, K. (2015). Medicinal Plants with Potential Antipyretic Activity: A Review. Asian Pacific Journal of Tropical Disease, 5, S202–S208. https://doi.org/10.1016/
S2222-1808(15)60890-8
Widyaningrum, N. R., & Ningrum, A. N. (2021). Identifikasi Kromatografi Lapis Tipis dan Aktivitas Antipiretik Ekstrak Etanol Daun Ipomoea Carnea Jacq Melalui Induksi Pepton pada Mencit Jantan. Avicenna: Journal of Health Research, 4(2). https://doi.org/10.36419/avicenna.
v4i2.534
Widyasari, R., Yuspitasari, D., Fadli, F., Masykuroh, A., & Tahuhiddah, W. (2018). Uji Aktivitas Antipiretik Ekstrak Daun Sisik Naga (Pyrrosia piloselloides (L.) M.G. Price) terhadap Tikus Putih (Rattus Norvegicus) Jantan Galur Wistar yang Diinduksi Pepton 5%. JIFFK: Jurnal Ilmu Farmasi dan Farmasi Klinik, 15(01), 22. https://doi.org/10.31942/jiffk.
v15i01.2169
Yassir, M., & Asnah, A. (2019). Pemanfaatan Jenis Tumbuhan Obat Tradisional di Desa Batu Hamparan Kabupaten Aceh Tenggara. Biotik: Jurnal Ilmiah Biologi Teknologi dan Kependidikan, 6(1). https://doi.org/10.22373/biotik.v6i1.4039
License
Copyright (c) 2024 Wanda Qoriasmadillah, Nirwana Haqiqi, Zuhratul Iman, Tri Wahyu Setyaningrum, Dining Aidil Candri, Andri Frediansyah, Eka Sunarwidhi Prasedya
This work is licensed under a Creative Commons Attribution 4.0 International License.
Authors who publish with Jurnal Penelitian Pendidikan IPA, agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution 4.0 International License (CC-BY License). This license allows authors to use all articles, data sets, graphics, and appendices in data mining applications, search engines, web sites, blogs, and other platforms by providing an appropriate reference. The journal allows the author(s) to hold the copyright without restrictions and will retain publishing rights without restrictions.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in Jurnal Penelitian Pendidikan IPA.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
