Histopathological Features and Diagnosis of Breast Cancer
DOI:
10.29303/jppipa.v10i11.8469Published:
2024-11-25Issue:
Vol. 10 No. 11 (2024): NovemberKeywords:
Breast cancer, Diagnosis, Histopathological features, Mammary carcinomaReview
Downloads
How to Cite
Downloads
Metrics
Abstract
In Indonesia, the high number of breast cancer cases is not always followed by complete clinical and histopathological determination, even though clinical and histopathological staging is needed to determine the diagnosis and further management. Breast cancer is a malignant mass originates from the uncontrolled division of cells in breast tissue Breast cancer or mammary carcinoma is a lump that grows and develops abnormally in the cells and tissues located in the breast, such as the fat tissue and connective tissue in the breast, ducts and lobules. The histopathological examination procedure is that the patient must undergo a biopsy. Biopsy results can be used to diagnose breast cancer and also monitor the success of therapy. Mammary carcinoma can spread to surrounding tissue or to other organs through blood vessels. Breast cancer is the most common cancer in Indonesia. The prognosis of breast cancer is determined by the 5 years survival rate. The survival rate for cancer sufferers in Indonesia is low compared to other developing countries, namely 51.07%. This research is in the form of a literature review with 14 papers as references. The results obtained were that invasive ductal carcinoma was the most common mammary carcinoma and grade II-III was found to be the dominant grade.
References
Alkhafaji, S., Wolf, D. M., Magbanua, M. J. M., J. Van ‘T Veer, L., Park, J. W., Esserman, L., & Mukhtar, R. A. (2024). Circulating tumor cells in early lobular versus ductal breast cancer and their associations with prognosis. Npj Breast Cancer, 10(1), 17. https://doi.org/10.1038/s41523-024-00623-9
Amin, M. B., Greene, F. L., Edge, S. B., Compton, C. C., Gershenwald, J. E., Brookland, R. K., Meyer, L., Gress, D. M., Byrd, D. R., & Winchester, D. P. (2017). The Eighth Edition AJCC Cancer Staging Manual: Continuing to build a bridge from a population‐based to a more “personalized” approach to cancer staging. CA: A Cancer Journal for Clinicians, 67(2), 93–99. https://doi.org/10.3322/caac.21388
Barili, V., Ambrosini, E., Bortesi, B., Minari, R., De Sensi, E., Cannizzaro, I. R., Taiani, A., Michiara, M., Sikokis, A., Boggiani, D., Tommasi, C., Serra, O., Bonatti, F., Adorni, A., Luberto, A., Caggiati, P., Martorana, D., Uliana, V., Percesepe, A., … Pellegrino, B. (2024). Genetic Basis of Breast and Ovarian Cancer: Approaches and Lessons Learnt from Three Decades of Inherited Predisposition Testing. Genes, 15(2), 219. https://doi.org/10.3390/genes15020219
Barroso-Sousa, R., & Metzger-Filho, O. (2016). Differences between invasive lobular and invasive ductal carcinoma of the breast: Results and therapeutic implications. Therapeutic Advances in Medical Oncology, 8(4), 261–266. https://doi.org/10.1177/1758834016644156
Bonni, S., Brindley, D. N., Chamberlain, M. D., Daneshvar-Baghbadorani, N., Freywald, A., Hemmings, D. G., Hombach-Klonisch, S., Klonisch, T., Raouf, A., Shemanko, C. S., Topolnitska, D., Visser, K., Vizeacoumar, F. J., Wang, E., & Gibson, S. B. (2024). Breast Tumor Metastasis and Its Microenvironment: It Takes Both Seed and Soil to Grow a Tumor and Target It for Treatment. Cancers, 16(5), 911. https://doi.org/10.3390/cancers16050911
Budzik, M. P., Fudalej, M. M., & Badowska-Kozakiewicz, A. M. (2021). Histopathological analysis of mucinous breast cancer subtypes and comparison with invasive carcinoma of no special type. Scientific Reports, 11(1), 5770. https://doi.org/10.1038/s41598-021-85309-z
Chiang, C.-L., Liang, H.-L., Chou, C.-P., Huang, J.-S., Yang, T.-L., Chou, Y.-H., & Pan, H.-B. (2016). Easily recognizable sonographic patterns of ductal carcinoma in situ of the breast. Journal of the Chinese Medical Association, 79(9), 493–499. https://doi.org/10.1016/j.jcma.2016.03.009
Davis, A. A., Gerratana, L., Clifton, K., Medford, A. J., Velimirovic, M., Hensing, W. L., Bucheit, L., Shah, A. N., D’Amico, P., Reduzzi, C., Zhang, Q., Dai, C. S., Denault, E. N., Bagegni, N. A., Opyrchal, M., Ademuyiwa, F. O., Bose, R., Gradishar, W. J., Behdad, A., … Cristofanilli, M. (2022). Circulating tumour DNA characterisation of invasive lobular carcinoma in patients with metastatic breast cancer. eBioMedicine, 86, 104316. https://doi.org/10.1016/j.ebiom.2022.104316
Elsaeid, Y. M., Elmetwally, D., & Eteba, S. M. (2019). Association between ultrasound findings, tumor type, grade, and biological markers in patients with breast cancer. Egyptian Journal of Radiology and Nuclear Medicine, 50(1), 53. https://doi.org/10.1186/s43055-019-0048-1
Fares, J., Fares, M. Y., Khachfe, H. H., Salhab, H. A., & Fares, Y. (2020). Molecular principles of metastasis: A hallmark of cancer revisited. Signal Transduction and Targeted Therapy, 5(1), 28. https://doi.org/10.1038/s41392-020-0134-x
Giannandrea, F., & Fargnoli, S. (2017). Environmental Factors Affecting Growth and Occurrence of Testicular Cancer in Childhood: An Overview of the Current Epidemiological Evidence. Children, 4(1), 1. https://doi.org/10.3390/children4010001
Goliwas, K. F., Richter, J. R., Pruitt, H. C., Araysi, L. M., Anderson, N. R., Samant, R. S., Lobo-Ruppert, S. M., Berry, J. L., & Frost, A. R. (2017). Methods to Evaluate Cell Growth, Viability, and Response to Treatment in a Tissue Engineered Breast Cancer Model. Scientific Reports, 7(1), 14167. https://doi.org/10.1038/s41598-017-14326-8
Hrizat, A., & Brachtel, E. (2022). Metastatic Breast Cancer: Cytology Diagnosis with Implications for Treatment. Journal of Molecular Pathology, 4(1), 1–14. https://doi.org/10.3390/jmp4010001
Huang, S., Gongye, R., Zou, S., Hee, J. Y., & Tang, K. (2023). Menopausal status, age at menopause and risk of all-cause mortality among Chinese women: Findings from a 10-year prospective study. BMJ Public Health, 1(1), e000332. https://doi.org/10.1136/bmjph-2023-000332
Huysentruyt, L. C., & Seyfried, T. N. (2010). Perspectives on the mesenchymal origin of metastatic cancer. Cancer and Metastasis Reviews, 29(4), 695–707. https://doi.org/10.1007/s10555-010-9254-z
Koufopoulos, N., Pateras, I. S., Gouloumis, A. R., Ieronimaki, A. I., Zacharatou, A., Spathis, A., Leventakou, D., Economopoulou, P., Psyrri, A., Arkadopoulos, N., & Panayiotides, I. G. (2022). Diagnostically Challenging Subtypes of Invasive Lobular Carcinomas: How to Avoid Potential Diagnostic Pitfalls. Diagnostics, 12(11), 2658. https://doi.org/10.3390/diagnostics12112658
Kundu, S., & Acharya, S. S. (2024). Exploring the triggers of premature and early menopause in India: A comprehensive analysis based on National Family Health Survey, 2019–2021. Scientific Reports, 14(1), 3040. https://doi.org/10.1038/s41598-024-53536-9
Makhlouf, S., Atallah, N. M., Polotto, S., Lee, A. H. S., Green, A. R., & Rakha, E. A. (2024). Deciphering the Clinical Behaviour of Invasive Lobular Carcinoma of the Breast Defines an Aggressive Subtype. Cancers, 16(10), 1893. https://doi.org/10.3390/cancers16101893
Marrazzo, E., Frusone, F., Milana, F., Sagona, A., Gatzemeier, W., Barbieri, E., Bottini, A., Canavese, G., Rubino, A. O., Eboli, M. G., Rossetti, C. M., Testori, A., Errico, V., De Luca, A., & Tinterri, C. (2020). Mucinous breast cancer: A narrative review of the literature and a retrospective tertiary single-centre analysis. The Breast, 49, 87–92. https://doi.org/10.1016/j.breast.2019.11.002
Martinez-Calle, N., Isbell, L. K., Cwynarski, K., & Schorb, E. (2021). Treatment of elderly patients with primary CNS lymphoma. Annals of Lymphoma, 5, 2–2. https://doi.org/10.21037/aol-20-30
Missaoui, A. M., Hamza, F., Belabed, W., Mellouli, M., Maaloul, M., Charfi, S., Jardak, I., Sellami-Boudawara, T., Rekik, N., & Abid, M. (2023). Warthin-like papillary thyroid carcinoma: A case report and comprehensive review of the literature. Frontiers in Endocrinology, 14, 1210943. https://doi.org/10.3389/fendo.2023.1210943
Naponelli, V., Rocchetti, M. T., & Mangieri, D. (2024). Apigenin: Molecular Mechanisms and Therapeutic Potential against Cancer Spreading. International Journal of Molecular Sciences, 25(10), 5569. https://doi.org/10.3390/ijms25105569
Ng, B., Puspitaningtyas, H., Wiranata, J. A., Hutajulu, S. H., Widodo, I., Anggorowati, N., Sanjaya, G. Y., Lazuardi, L., & Sripan, P. (2023). Breast cancer incidence in Yogyakarta, Indonesia from 2008–2019: A cross-sectional study using trend analysis and geographical information system. PLOS ONE, 18(7), e0288073. https://doi.org/10.1371/journal.pone.0288073
Peters, A., Keating, M.-M., Nikonova, A., Doucette, S., & Prica, A. (2023). Management of Marginal Zone Lymphoma: A Canadian Perspective. Current Oncology, 30(2), 1745–1759. https://doi.org/10.3390/curroncol30020135
Rädler, P. D., Wehde, B. L., Triplett, A. A., Shrestha, H., Shepherd, J. H., Pfefferle, A. D., Rui, H., Cardiff, R. D., Perou, C. M., & Wagner, K.-U. (2021). Highly metastatic claudin-low mammary cancers can originate from luminal epithelial cells. Nature Communications, 12(1), 3742. https://doi.org/10.1038/s41467-021-23957-5
Reardon, D., & Arvold, N. (2014). Treatment options and outcomes for glioblastoma in the elderly patient. Clinical Interventions in Aging, 357. https://doi.org/10.2147/CIA.S44259
Riggio, A. I., Varley, K. E., & Welm, A. L. (2021). The lingering mysteries of metastatic recurrence in breast cancer. British Journal of Cancer, 124(1), 13–26. https://doi.org/10.1038/s41416-020-01161-4
Rossi, E. D., Pantanowitz, L., & Hornick, J. L. (2021). Cytologic and histological features of rare nonepithelial and nonlymphoid tumors of the thyroid. Cancer Cytopathology, 129(8), 583–602. https://doi.org/10.1002/cncy.22404
Royce Sadler, D. (2014). The futility of attempting to codify academic achievement standards. Higher Education, 67(3), 273–288. https://doi.org/10.1007/s10734-013-9649-1
Rudolph, A., Chang-Claude, J., & Schmidt, M. K. (2016). Gene–environment interaction and risk of breast cancer. British Journal of Cancer, 114(2), 125–133. https://doi.org/10.1038/bjc.2015.439
Ruscitto, F., Roda, N., Priami, C., Migliaccio, E., & Pelicci, P. G. (2022). Beyond Genetics: Metastasis as an Adaptive Response in Breast Cancer. International Journal of Molecular Sciences, 23(11), 6271. https://doi.org/10.3390/ijms23116271
Schindler, L. A., Burkholder, G. J., Morad, O. A., & Marsh, C. (2017). Computer-based technology and student engagement: A critical review of the literature. International Journal of Educational Technology in Higher Education, 14(1), 25. https://doi.org/10.1186/s41239-017-0063-0
Sinaga, E. S., Ahmad, R. A., Shivalli, S., & Hutajulu, S. H. (2018). Age at diagnosis predicted survival outcome of female patients with breast cancer at a tertiary hospital in Yogyakarta, Indonesia. Pan African Medical Journal, 31. https://doi.org/10.11604/pamj.2018.31.163.17284
Smolarz, B., Nowak, A. Z., & Romanowicz, H. (2022). Breast Cancer—Epidemiology, Classification, Pathogenesis and Treatment (Review of Literature). Cancers, 14(10), 2569. https://doi.org/10.3390/cancers14102569
So, W. K. W., Law, B. M. H., Ng, M. S. N., He, X., Chan, D. N. S., Chan, C. W. H., & McCarthy, A. L. (2021). Symptom clusters experienced by breast cancer patients at various treatment stages: A systematic review. Cancer Medicine, 10(8), 2531–2565. https://doi.org/10.1002/cam4.3794
Sukmana, D. J., Mentari, I. N., & Anjelin, D. P. (2021). Study of Creatinin Levels of Patients Receiving Antipsycotic Treatment at Mutiara Sukma Psychiatric Hospital, Nusa Tenggara Barat. Medicra (Journal of Medical Laboratory Science/Technology), 4(2), 83–87. https://doi.org/10.21070/medicra.v4i2.1616
Tabár, L., Bozó, R., Dean, P. B., Ormándi, K., Puchkova, O., Oláh-Németh, O., Németh, I. B., Veréb, Z., Yen, M.-F., Chen, L.-S., Chen, H.-H., & Vörös, A. (2023). Does Diffusely Infiltrating Lobular Carcinoma of the Breast Arise from Epithelial–Mesenchymal Hybrid Cells? International Journal of Molecular Sciences, 24(13), 10752. https://doi.org/10.3390/ijms241310752
Tay, T. K. Y., & Tan, P. H. (2021). Papillary neoplasms of the breast—Reviewing the spectrum. Modern Pathology, 34(6), 1044–1061. https://doi.org/10.1038/s41379-020-00732-3
Yersal, O. (2014). Biological subtypes of breast cancer: Prognostic and therapeutic implications. World Journal of Clinical Oncology, 5(3), 412. https://doi.org/10.5306/wjco.v5.i3.412
Zarychta, E., & Ruszkowska-Ciastek, B. (2022). Cooperation between Angiogenesis, Vasculogenesis, Chemotaxis, and Coagulation in Breast Cancer Metastases Development: Pathophysiological Point of View. Biomedicines, 10(2), 300. https://doi.org/10.3390/biomedicines10020300
Author Biographies
Ghina Shadrina Rienti Sepestian, Universitas Mataram
Fathul Djannah, Universitas Mataram
License
Copyright (c) 2024 Ghina Shadrina Rienti Sepestian, Fathul Djannah
This work is licensed under a Creative Commons Attribution 4.0 International License.
Authors who publish with Jurnal Penelitian Pendidikan IPA, agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution 4.0 International License (CC-BY License). This license allows authors to use all articles, data sets, graphics, and appendices in data mining applications, search engines, web sites, blogs, and other platforms by providing an appropriate reference. The journal allows the author(s) to hold the copyright without restrictions and will retain publishing rights without restrictions.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in Jurnal Penelitian Pendidikan IPA.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
