The Potential Of Fungi And Bacteria As α-Glucosidase Inhibitors For The Future Treatment Of Type 2 Diabetes
DOI:
10.29303/jppipa.v11i1.9457Published:
2025-01-24Issue:
Vol. 11 No. 1 (2025): In ProgressKeywords:
Bacteria, Endophyte Fungi, α-Glucosidase InhibitorsReview
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Abstract
Diabetes, a disorder of hemostasis of carbohydrate and lipid metabolism, is one of today's leading killers. The most prevalent form of diabetes is type 2 diabetes mellitus (T2DM). Rapid hydrolysis of starch by pancreatic α-amylase and α-glucosidase, followed by intestinal absorption of glucose, causes a sudden increase in blood glucose. Available therapies for T2DM are oral insulin secretagogues, sulfonylureas, repaglinide, nateglinide, biguanides, thiazolidinediones, α-glucosidase, inhibitors and insulin. However, several hypoglycemic agents have limitations, such as side effects and increased diabetes complications. α-glucosidase inhibitors are structurally similar to natural oligosaccharides with a higher affinity for α-glucosidases, and they produce a reversible inhibition of membrane-bound intestinal α-glucoside hydrolase enzymes. This causes delayed carbohydrate absorption and digestion and results in a reduction in postprandial hyperglycemia. Natural α-glucosidase inhibitor drugs from natural sources can be used as a therapeutic approach to treat postprandial hyperglycemia for their assumed lower side effect and more affordable price than synthetic drugs. In this article, the author summarizes the potential of α-glucosidase inhibitors from microorganisms, namely fungi and bacteria, along with several active compounds with better activity than commercial α-glucosidase inhibitors.
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Author Biographies
Edy Fachrial, Universitas Riau
Ismawati, Universitas Riau
Afif P Jati, Indonesia Bioinformatics Research Center
Titania T Nugroho, Universitas Riau
Saryono, Universitas Riau
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Copyright (c) 2025 Edy Fachrial, Ismawati, Afif P Jati, Titania T Nugroho, Saryono

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