Routine Hematology Findings in Pulmonary Tuberculosis Cases at Regional General Hospital of Dr. Pirngadi, Medan, Indonesia
DOI:
10.29303/jppipa.v11i2.10370Published:
2025-02-25Issue:
Vol. 11 No. 2 (2025): FebruaryKeywords:
Erythrocyte sedimentation rate, Hemoglobin, Leukocytes, Pulmonary tuberculosis, Routine hematologicResearch Articles
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Abstract
Pulmonary Tuberculosis (TB) is an infection of the lung parenchyma caused by Mycobacterium tuberculosis and is transmitted via droplets. A routine hematological examination is crucial for evaluating disease progression, complications, and therapeutic responses. Thus, this study aimed to To identify routine hematological characteristics in pulmonary tuberculosis patients in RSUD Dr. Pirngadi Kota Medan. This observational study with cross-sectional design included 105 pulmonary tuberculosis patients, that selected via total sampling technique from 2019 to 2020. Data on demographic characteristics (age, sex, and occupation) and hematological profiles were analyzed. The majority of patients were male (67.6%), aged 46–55 years (24.8%), and worked as self-employed (47.6%). Hematological profiles showed elevated neutrophils (72.4%) and erythrocyte sedimentation rate (53.3%), alongside reduced hemoglobin (58.1%), hematocrit (61%), and lymphocytes (83.8%). Most patients had normal number of leukocytes (52.4%), platelets (63.8%), monocytes (47.6%), eosinophils (87.6%), and basophils (99%). he most characteristic routine hematological changes in pulmonary tuberculosis patients include decreased hemoglobin, hematocrit, and lymphocytes, as well as increased neutrophils and erythrocyte sedimentation rate. These findings emphasize the importance of hematological examination in the diagnosis and monitoring of pulmonary tuberculosis.
References
Aravindhan, V., Bobhate, A., Sathishkumar, K., Patil, A., Kumpatla, S., & Viswanathan, V. (2022). Unique Reciprocal Association Seen Between Latent Tuberculosis Infection and Diabetes Is Due to Immunoendocrine Modulation (DM-LTB-1). Frontiers in Microbiology, 13(884374). https://doi.org/10.3389/fmicb.2022.884374
Argan, R. J. A., & Elq, A. H. A. (2021). Trombositopenia Imun terkait Tuberkulosis. Jurnal Kedokteran & Ilmu kedokteran Saudi. https://doi.org/10.4103/sjmms.sjmms
Badan Pusat Statistik Provinsi Sumatera Utara. (2020). Jumlah Kasus Penyakit Menurut Kabupaten/Kota dan Jenis Penyakit di Provinsi Sumatera Utara 2020. BPS Sumut.
Bahar, A., & Amin, Z. (2017). Tuberkulosis Paru. In Buku Ajar Ilmu Penyakit Dalam (6th ed., pp. 863–883). Interna Publishing.
Banerjee, M., Chaudhary, B. L., & Shukla, S. (2015). Hematological Profile Among Pulmoary Tuberculosis Patients In Tertiary Care Hospital. International Journal Of Bioassays, 4(5), 3900–3901. Retrieved from https://www.ijbio.com/articles/hematological-profile-among-pulmonary-tuberculosis-patients-in-tertiary-care-hospital.pdf
Burhan, E., Soeroto, A. Y., & Isbaniah, F. (2020). Pedoman Nasional Pelayanan Kedokteran Tata Laksana Tuberkulosis. Kementerian Kesehatan RI.
Brahmadhi, A., & Annisa, Y. (2016). Perbandingan antara Penderita Tuberkulosis Perokok dan Bukan Perokok Berdasarkan Basil Tahanan Asam (BTA) di RSUD Banyumas. Jurnal Ilmiah Ilmu-Ilmu Kesehatan, 14(3), 113–118. https://doi.org/10.30595/medisains.v14i3.1620
Ergiana, S. D., Wardani D. P. W., Sudarsono, T. A., & Mulyono, A. (2022). Jurnal Surya Mandalika, 8(2), 62-77. https://doi.org/10.33084/jsm.v8i2.3482
Ellies-Tunjung, S. (2020). Status Kadar Hemoglobin Dan Jenis Leukosit Pada Pasien TB Paru Di Surabaya. The Journal Of Muhammadiyah Medical Laboratory Technologist, 3(1), 53–59. https://doi.org/10.30651/jmlt.v3i1.4013
Fathana, P. B., Buanayuda, G. W., & Putri, N. A. (2017). Hematologic Examination In Pulmonary Tuberculosis Patient Addmitted In General Hospital West Nusa Tenggara Barat Province in 2011-2012. Jurnal Kedokteran, 2(3), 27–37. https://doi.org/10.29303/jku.v2i3.65
Fitria, E., Ramadhan, R., & Rosdiana, R. (2017). Karakteristik Penderita Tuberkulosis Paru di Puskesmas Rujukan Mikroskopis Kabupaten Aceh Besar. Sel Jurnal Penelitian Kesehatan, 4(1), 13–20. https://doi.org/10.22435/sel.v4i1.1441
Fitri, L. D., Marlindawani, J., & Purba, A. (2018). Kepatuhan Minum Obat pada Pasien Tuberkulosis Paru. Jurnal Ilmu Kesehatan Masyarakat, 7(01), 33–42. https://doi.org/10.33221/jikm.v7i1.50
Gupta, A., Sural, S., Rousa, S., Koner, B. C., Bhalotra, A., & Chawla, R. (2021). Positive QuantiFERON test and the severity of COVID-19 disease: A prospective study. Indian Journal of Tuberculosis, 68, 474–480. https://doi.org/10.1016/j.ijtb.2020.12.013
Haryanik, M. A. P., Noveyani, A. E., & Meikalynda, A. (2023). Descriptive Epidemiology of Tuberculosis during 2019-2022 in the Working Area of Arjasa Primary Healthcare, Jember Regency. Contagion: Scientific Periodical Journal of Public Health and Coastal Health, 5(1), 113–125. https://doi.org/10.30829/contagion.v5i1.1481
Hidayat, T., & Firdhania, N. (2023). Hububgan Antara Persepsi Ancaman Terhadap Kesehatan dengan Tingkat Kepatuhan Minum Obat pada Penderita TB Paru. Jurnal Ilmu Kesehatan Insan Sehat Stikes Intan Martapura, 11(2). https://doi.org/10.54004/jikis.v11i2.132
Honda, T., Uehara, T., Matsumoto, G., Arai, S., & Sugano, M. (2016). Neutrophil left shift and white blood cell count as markers of bacterial infection. Clinica Chimica Acta; International Journal of Clinical Chemistry, 457, 46–53. Retrieved from https://api.semanticscholar.org/CorpusID:24016355
Kalma, K., Rafika, R., & Bahctiar, A. R. (2019). Trombosit dan Kadar Hemoglobin Pada Pasien Tuberkulosis Konsumsi Obat Anti Tuberkulosis (OAT). Jurnal Media Analis Kesehatan, 10(2), 143–148. https://doi.org/10.32382/mak.v10i2.1302
Kasih, K. N., & Sulastina, N. A. (2019). Analisi Laju Endap Darah Pada Pasien Tuberkulosis Paru. Jurnal Aisyiyah Medika, 4(1), 45–51. https://doi.org/10.36729/jam.v4i1.970
Kassa, E., Enawgaw, B., Gelaw, A., & Gelaw, B. (2016). Effect of anti-tuberculosis drugs on hematological profiles of tuberculosis patients attending at University of Gondar Hospital, Northwest Ethiopia. BMC Hematology, 16(1), 1–11. https://doi.org/10.1186/s12878-015-0037-1
Khaironi, S., Rahmita, M., & Siswani, R. (2017). Gambaran Jumlah Leukosit dan Jenis Leukosit Pada Pasien Tuberkulosis Paru Sebelum Pengobatan Dengan Setelah Pengobatan Satu Bulan Intensif Di Puskesmas Pekanbaru. Jurnal Analis Kesehatan Klinikal Sains, 5(2), 68–70. Retrieved from https://moraref.kemenag.go.id/documents/article/99047180253281917
Khariri. (2020). Pemeriksaan Basil Tahan Asam (BTA) pada Sputum dengan Pewarnaan Ziehl Neelsen ( ZN ) Sebagai Metode Populer untuk Penegakkan Diagnosis TB Paru. Sinergitas Multidisiplin Ilmu Pengetahuan Dan Teknologi, 3(1), 132–139. Retrieved from https://jurnal.yapri.ac.id/index.php/semnassmipt/article/view/159
Lasut, N. M., Rotty, L. W. A., & Polii, E. B. I. (2016). Gambaran Kadar Hemoglobin Dan Trombosit PadaPasien Tuberkulosis Paru Di RSUP. PROF.Dr. R. D. Kandou Manado PeriodeJanuari 2014–Desember 2014. Jurnal Ilmiah Kedokteran Klinik, 4(1), https://doi.org/10.35790/ecl.v4i1.11025
Maphasa, R. E., Mayer, M., & Dube, A. (2021). The Macrophage Response to Mycobacterium Tuberculosis and Opportunities for Autophagy Inducing Nanomedicines for Tuberculosis Therapy. Front Cell Infect Microbiol, 8(10). https://doi.org/10.3389/fcimb.2020.618414
Mandal, S. K., & Chavan, L. (2016). Hematological Profile in Patients Suffering from Tuberculosis and Treatment Response. Journal of Medical Science and Clinical Research, 4(10), 13146–13150. https://dx.doi.org/10.18535/jmscr/v4i10.56
Mulidan, M., Dedi, D., & Khadafi, M. (2021). Dukungan Keluarga Berhubungan dengan Kepatuhan Minum Obat pada Pasien Tuberkulosis Paru. Penelitian Perawat Profesional, 3(3), 575–584. https://doi.org/10.37287/jppp.v3i3.549
Netty, N., Kasman, K., & Ayu, S. D. (2018). Hubungan Peran Petugas Kesehatan Dan Dukungan Keluarga Dengan Tingkat Kepatuhan Minum Obat Pada Penderita Tuberkulosis (TB) Paru Bta Positif di Wilayah Kerja UPT. Puskesmas Martapura 1. An-Nadaa: Jurnal Kesehatan Masyarakat, 5(1), 45–50. https://doi.org/10.31602/ann.v5i1.1728
Ramadhan, R., Fitria, E., & Rosdiana. (2017). Deteksi Mycbacterium Tuberkulosis dengan Pemeriksan Mikroskopis dan Teknik PCR Pada Penderita Tuberkulosis Paru di Puskesmas Darul Imarah. Jurnal Penelitian Kesehatan, 4(2), 74–79. https://doi.org/10.22435/sel.v4i2.1463
Rampa, E., Fitrianingsih, & Sinaga, H. (2020). Hasil Pemeriksaan Leukosit, Trombosit dan Hemoglobin pada Penderita Tuberkulosis yang Mengkonsumsi OAT di RSAL Dr. Soedibjo Sardadi Kota Jayapura. Health Science (Ghs), 5(2), 78–83. https://dx.doi.org/10.33846/ghs5206
Ruditya, D. N. (2017). Hubungan Antara Karakterikstik Penderita TB dengan Kepatuhan Memeriksakan Dahak Selama Pengobatan. Jurnal Berkala Epidemiologi, 3(2), 122–133. Retrieved from https://e-journal.unair.ac.id/JBE/article/download/1649/1270
Rumimpunu, R., Maramis, F. R., & Kolibu, F. K. (2018). Hubungan Antara Dukungan Keluarga dan Dorongan Petugas Kesehatan Dengan Kepatuhan Berobat Penderita Tuberkulosis Paru di Puskesmas Likupang Kabupaten Minahasa Utara. Jurnal KESMAS, 7(4). Retrieved from https://ejournal.unsrat.ac.id/index.php/kesmas/article/view/23114
Sadewo, S. W., Salam, A., & Rialita, A. (2016). Gambaran Status Anemia pada Pasien Tuberkulosis Paru di Unit Pengobatan Penyakit Paru-Paru Provinsi Kalimantan Barat Tahun 2010-2012. Jurnal Cerebellum, 2(3), 596–598. Retrieved from https://www.neliti.com/id/publications/193104
Sari, I. D., Mubasyiroh, R., & Supardi, S. (2017). Hubungan Pengetahuan dan Sikap dengan Kepatuhan Berobat pada Pasien TB Paru yang Rawat Jalan di Jakarta Tahun 2014. Media Penelitian Dan Pengembangan Kesehatan, 26(4), 243–248. https://doi.org/10.22435/mpk.v26i4.4619.
Siallagan, A., Tumanggor, L. S., & Sihotang, M. (2023). Hubungan Dukungan Keluarga dengan Kepatuhan Minum Obat pada Pasien Tuberculosis Paru. Penelitian Perawat Profesional, 5(3), 1199–1208. https://doi.org/10.37287/jppp.v5i3.1779
Sherman, H., Fauzi, Z. I., Panjaitan, R. M., & Taringan, R. (2023). Analysis of Adherence Factors to Tuberculosis Therapy at the PB Selayang II Health Center, Medan City. Scientific Periodical Jurnal of Public Health and Coastal Health, 5(4), http://dx.doi.org/10.30829/contagion.v5i4.17797
Shafee, M., Abbas, F., Ashraf, M., & Mengal, M. A. (2014). Hematological Profile and Risk Factors Associated With Pulmonary Tuberculosis Patients in Quetta, Pakistan. Pakistan Jurnal of Medical Sciences Online, 30(1), 36-40. https://doi.org/10.12669/pjms.301.4129
Sinaga, H. (2019). Examination of Pulmonary Tuberculosis Patients At the Regional General Hospital (Rsud) Jayapura. Jurnal Riset Kesehatan, 8(2), 21. https://doi.org/10.31983/jrk.v8i2.5364
Sulochana, S., Subhashini, V., & Srinivasan, C. (2018). Pulmonary tuberculosis. Asian Journal of Pharmaceutical and Clinical Research, 11(4), 169–172. https://doi.org/10.22159/ajpcr.2018.v11i4.23177
Talakua, R. W., Latuconsina, V. Z., & Malawat, S. H. (2021). Gambaran Kadar Hemoglobin dan Indeks Eritrosit pada Pasien Tuberkulosis Paru di RSUD Dr. M. Haulussy Ambon Priode Januari 2017 - April 2018. Pameri Pattimura Medical Review, 2(2), 82-89. https://doi.org/10.30598/pamerivol2issue2page82-89
Utami, N. A., Tunru, I. S. A., & Yusnita, Y. (2018). Hubungan Tingkat Pengetahuan Terhadap Keberhasilan Pengobatan Tuberkulosis di Puskesmas Kecamatan Johar Baru Jakarta Pusat Tahun 2016. Jurnal Kedokteran dan Kesehatan, 12(2). https://doi.org/10. 33533/jpm.v12i2.262
World Health Organization. (2020a). Global tuberculosis report 2020. Retrieved from https://iris.who.int/bitstream/handle/10665/336069/9789240013131-eng.pdf
World Health Organization. (2020). Tuberculosis. Retrieved from http://apps.who.int/iris/bitstream/10665/191102/1/9789241565059
World Health Organization. (2021). Tuberculosis. Retrieved from http://apps.who.int/iris/bitstream/10665/191102/1/9789241565059
Wulandini, P., Saputra, R., Sartika, W., & Qomariah, S. (2020). Hubungan peran pengawasan petugas kesehatan terhadap kepatuhan konsumsi obat pasien TBC di wilayah kerja Puskesmas Perawang Kec. Tualang Kabupaten Siak. Jurnal Kesehatan Masyarakat Maritim, 3(3), 155–160. Retrieved from https://journal.unhas.ac.id/index.php/jkmmunhas/article/view/12218
Author Biographies
Jenny Ria Sihombing, Universitas HKBP Nommensen
Gabriella M.C. Sipahutar, Martha Friska Multatuli Hospital
Nathalia E.R. Sipahutar, At-Taqwa Gumawang Islamic Hospital
Rotua Chatarina Simanjuntak, Universitas HKBP Nommensen
Suhartomi, Universitas Prima Indonesia
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Copyright (c) 2025 Jenny Ria Sihombing, Gabriella M.C. Sipahutar, Nathalia E.R. Sipahutar, Rotua Chatarina Simanjuntak, Suhartomi

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