Systematic Literature Review: Visualizing of Molecular Structures and Chemical Reactions Through Augmented Reality (AR)
Bahasa Indonesia
DOI:
10.29303/jppipa.v12i8.15052Published:
2026-08-31Downloads
Abstract
This article explores molecular structures and chemical reactions in augmented reality (AR) created between 2021-2025. The goal of this research is to identify the most advanced forms of augmented reality, materials related to molecular structures and chemical reactions that have been developed as augmented reality, and the benefits of augmented reality in the study of these topics. This study's methodology is a systematic review of the literature. Three steps are involved in conducting a systematic literature review: planning, implementation, and reporting. This article have 16 publications were found using the criteria based on the study's findings, and additional analysis was done. The analysis's findings demonstrate how different kinds of augmented reality, both marker-based and markerless, are generated molecular structures and chemical reactions. The most advanced useful is hybrid AR for molecular structures and chemical reactions. The most advanced content in the form of instructional games includes geometry and symmetrical molecules, which have been demonstrated to enhance students' molecular comprehension
Keywords:
Augmented reality Chemistry Molecular Systematic literature reviewReferences
Ardura, D., Zamora, Á., & Pérez-Bitrián, A. (2021). The role of motivation on secondary school students’ causal attributions to choose or abandon chemistry. Chemistry Education Research and Practice, 22(1), 77–92. https://doi.org/10.1039/d0rp00168f
Azuma, R. T. (1997). A Survey of Augmented Reality. Presence: Teleoperators and Virtual Environments, 6(4), 355–385. https://doi.org/10.1162/pres.1997.6.4.355
Câmara Olim, S., Nisi, V., & Romão, T. (2024). Augmented reality interactive experiences for multi-level chemistry understanding. International Journal of Child-Computer Interaction, 42(July). https://doi.org/10.1016/j.ijcci.2024.100681
Castro-Alonso, J. C., Ayres, P., & Sweller, J. (2019). Instructional Visualizations, Cognitive Load Theory, and Visuospatial Processing. In Visuospatial Processing for Education in Health and Natural Sciences (pp. 111–143). Springer International Publishing. https://doi.org/10.1007/978-3-030-20969-8_5
Chang, H. Y., Binali, T., Liang, J. C., Chiou, G. L., Cheng, K. H., Lee, S. W. Y., & Tsai, C. C. (2022). Ten years of augmented reality in education: A meta-analysis of (quasi-) experimental studies to investigate the impact. Computers and Education, 191(September), 104641. https://doi.org/10.1016/j.compedu.2022.104641
Chen, S.-Y., & Liu, S.-Y. (2020). Using augmented reality to experiment with elements in a chemistry course. Computers in Human Behavior, 111, 106418. https://doi.org/10.1016/j.chb.2020.106418
Coduto, J. R., Lazicki, A., & Leddy, J. (2024). Visualizing 3D Objects in Analytical Chemistry. Journal of Chemical Education, 101(1), 77–87. https://doi.org/10.1021/acs.jchemed.3c00821
Cortés Rodríguez, F., Dal Peraro, M., & Abriata, L. A. (2022). Online tools to easily build virtual molecular models for display in augmented and virtual reality on the web. Journal of Molecular Graphics and Modelling, 114(December). https://doi.org/10.1016/j.jmgm.2022.108164
Cortés Rodríguez, F. J., Frattini, G., Phloi-Montri, S., Pinto Meireles, F. T., Terrien, D. A., Cruz-León, S., Dal Peraro, M., Schier, E., Lindorff-Larsen, K., Limpanuparb, T., Moreno, D. M., & Abriata, L. A. (2025). MolecularWebXR: Multiuser discussions in chemistry and biology through immersive and inclusive augmented and virtual reality. Journal of Molecular Graphics and Modelling, 135(June). https://doi.org/10.1016/j.jmgm.2024.108932
Costa Coelho, F. da, de Magalhães Netto, J., & Almeida, T. O. (2022). A Case Study Using Augmented Reality for Teaching Organic Compound Reactions. 2022 IEEE Frontiers in Education Conference (FIE), 1–7. https://doi.org/10.1109/FIE56618.2022.9962460
Elford, D., Lancaster, S. J., & Jones, G. A. (2022). Fostering Motivation toward Chemistry through Augmented Reality Educational Escape Activities. A Self-Determination Theory Approach. Journal of Chemical Education, 99(10), 3406–3417. https://doi.org/10.1021/acs.jchemed.2c00428
Elford, D., Lancaster, S. J., & Jones, G. A. (2023). Augmented reality and worked examples: Targeting organic chemistry competence. Computers and Education: X Reality, 2(November), 100021. https://doi.org/10.1016/j.cexr.2023.100021
Fatemah, A., Rasool, S., & Habib, U. (2020). Interactive 3D Visualization of Chemical Structure Diagrams Embedded in Text to Aid Spatial Learning Process of Students. Journal of Chemical Education, 97(4), 992–1000. https://doi.org/10.1021/acs.jchemed.9b00690
Fombona-Pascual, A., Fombona, J., & Vicente, R. (2022). Augmented Reality, a Review of a Way to Represent and Manipulate 3D Chemical Structures. Journal of Chemical Information and Modeling, 62(8), 1863–1872. https://doi.org/10.1021/acs.jcim.1c01255
Gomollón-Bel, F. (2022). Discover the innovations that will transform energy, health, and materials science, to tackle the most urgent societal challenges and catalyse sustainable development. Chemistry International, 44(4), 4–13. https://doi.org/doi:10.1515/ci-2022-0402
Habig, S. (2020). Who can benefit from augmented reality in chemistry? Sex differences in solving stereochemistry problems using augmented reality. British Journal of Educational Technology, 51(3), 629–644. https://doi.org/10.1111/bjet.12891
Hoai, V. T. T., Son, P. N., An, D. T. T., & Anh, N. V. (2024). An Investigation into whether Applying Augmented Reality (AR) in Teaching Chemistry Enhances Chemical Cognitive Ability. International Journal of Learning, Teaching and Educational Research, 23(4), 195–216. https://doi.org/10.26803/ijlter.23.4.11
Hoai, V. T. T., Son, P. N., Em, V. V. D., & Duc, N. M. (2023). Using 3D molecular structure simulation to develop chemistry competence for Vietnamese students. Eurasia Journal of Mathematics, Science and Technology Education, 19(7). https://doi.org/10.29333/ejmste/13345
Horikoshi, R., Shirotani, D., & Shioyama, H. (2023). Studying the nomenclature of dioxins using a structure model kit based on electronic components linked with plastic tubes. Chemistry Teacher International, 5(1), 83–89. https://doi.org/10.1515/cti-2022-0051
Jeon, Y. E., Ji, J. Y., & Hong, H. G. (2024). Development and Evaluation of a Marker Arrangement-Based Mobile Augmented Reality Application for Learning Covalent and Ionic Bonding in the High School Curriculum. Journal of Chemical Education, 101(3), 1130–1138. https://doi.org/10.1021/acs.jchemed.3c01316
Keller, S., Rumann, S., & Habig, S. (2021). Cognitive load implications for augmented reality supported chemistry learning. Information (Switzerland), 12(3), 1–20. https://doi.org/10.3390/info12030096
Kenneally, C. D., & Bentley, B. (2024). A Cognitive Load Approach to Molecular Geometries: Augmented Reality Technology and Visuospatial Abilities in Chemistry. Education Sciences, 14(9). https://doi.org/10.3390/educsci14091036
Khan, K. S., Kunz, R., Kleijnen, J., & Antes, G. (2003). Five Steps to Conducting a Systematic Review. Journal of the Royal Society of Medicine, 96(3), 118–121. https://doi.org/10.1177/014107680309600304
Kum-Biocca, H. H., Farinas, E. T., Mistry, N., & Wan, Y. (2020). Molecular Augmented Reality for Design and Engineering (MADE): Effectiveness of AR Models on Discovery, Learning, and Education. In HCI International 2020 -- Late Breaking Posters (pp. 173–180). Springer International Publishing.
Laohapornchaiphan, J., & Chenprakhon, P. (2024). A Review of Research on Learning Activities Addressing the Submicroscopic Level in Chemistry. Journal of Chemical Education, 101(11), 4552–4565. https://doi.org/10.1021/acs.jchemed.4c00156
Lund, B., Harald, & H. (2016). Nordina : Nordic studies in science education. Nordic Studies in Science Education, 12(2), 157–174. Retrieved from https://www.journals.uio.no/index.php/nordina/article/view/2399/3336
Mazzuco, A., Krassmann, A. L., Reategui, E., & Gomes, R. S. (2022). A systematic review of augmented reality in chemistry education. Review of Education, 10(1), 1–26. https://doi.org/10.1002/rev3.3325
Mellander, E., & Lind, P. (2021). Recruitment to STEM studies: The roles of curriculum reforms, flexibility of choice, and attitudes. Review of Education, 9(2), 357–398. https://doi.org/10.1002/rev3.3262
Nechypurenko, P. P., Starova, T. V., Selivanova, T. V., Tomilina, A. O., & Uchitel, A. D. (2018). Use of augmented reality in chemistry education. CEUR Workshop Proceedings, 2257, 15–23. https://doi.org/10.31812/pedag.v51i0.3650
Okoli, C., & Schabram, K. (2012). A Guide to Conducting a Systematic Literature Review of Information Systems Research. SSRN Electronic Journal. https://doi.org/10.2139/ssrn.1954824
Ponticorvo, M., Di Fuccio, R., Ferrara, F., Rega, A., & Miglino, O. (2019). Multisensory Educational Materials: Five Senses to Learn. In Methodologies and Intelligent Systems for Technology Enhanced Learning, 8th International Conference (pp. 45–52). Springer International Publishing.
Rau, M. A. (2017). Conditions for the Effectiveness of Multiple Visual Representations in Enhancing STEM Learning. Educational Psychology Review, 29(4), 717–761. https://doi.org/10.1007/s10648-016-9365-3
Ripsam, M., & Nerdel, C. (2023). Teachers’ attitudes and self-efficacy toward augmented reality in chemistry education. Frontiers in Education, 8(January), 1–11. https://doi.org/10.3389/feduc.2023.1293571
Ripsam, M., & Nerdel, C. (2024). Augmented reality for chemistry education to promote the use of chemical terminology in teacher training. Frontiers in Psychology, 15(July), 1–23. https://doi.org/10.3389/fpsyg.2024.1392529
Silva, M., Bermúdez, K., & Caro, K. (2023). Effect of an augmented reality app on academic achievement, motivation, and technology acceptance of university students of a chemistry course. Computers and Education: X Reality, 2(April), 1–9. https://doi.org/10.1016/j.cexr.2023.100022
Smith, C., & Friel, C. J. (2021). Development and use of augmented reality models to teach medicinal chemistry. Currents in Pharmacy Teaching and Learning, 13(8), 1010–1017. https://doi.org/10.1016/j.cptl.2021.06.008
Syskowski, S., Lathwesen, C., Kanbur, C., Siol, A., Eilks, I., & Huwer, J. (2024). Teaching with Augmented Reality Using Tablets, Both as a Tool and an Object of Learning. Journal of Chemical Education, 101(3), 892–902. https://doi.org/10.1021/acs.jchemed.3c00607
Tarng, W., Tseng, Y., & Ou, K. (2022). Structures and Chemical Equilibrium in High School Chemistry. System, 10, 1–23. https://doi.org/10.3390/systems10050141
Vilia, P., & Candeias, A. A. (2020). Attitude towards the discipline of physics-chemistry and school achievement: revisiting factor structure to assess gender differences in Portuguese high-school students. International Journal of Science Education, 42(1), 133–150. https://doi.org/10.1080/09500693.2019.1706012
Xiao, Y., & Watson, M. (2019). Guidance on Conducting a Systematic Literature Review. Journal of Planning Education and Research, 39(1), 93–112. https://doi.org/10.1177/0739456X17723971
Yang, F. Y., & Wang, H. Y. (2023). Tracking visual attention during learning of complex science concepts with augmented 3D visualizations. Computers and Education, 193(October), 104659. https://doi.org/10.1016/j.compedu.2022.104659
Zambri, M. A., & De Backere, J. R. (2024). A Mobile Device Application for Visualizing Molecular Symmetry and Orbitals in Augmented Reality. Journal of Chemical Education, 101(2), 382–391. https://doi.org/10.1021/acs.jchemed.3c00652
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