Anthelmintics Activity of Red Pomegranate (Punica granatum) Peel Extract and Red Pomegranate (Punica granatum) Juice in Rabbit Experimental Animals

Authors

Erna Kristinawati , Erlin Yustin Tatontos , Zainal Fikri , Urip Urip

DOI:

10.29303/jppipa.v9i4.2901

Published:

2023-04-30

Issue:

Vol. 9 No. 4 (2023): April

Keywords:

Anthelmintics, Red pomegranate, Rabbits

Research Articles

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How to Cite

Kristinawati, E. ., Tatontos, E. Y., Fikri , Z. ., & Urip, U. (2023). Anthelmintics Activity of Red Pomegranate (Punica granatum) Peel Extract and Red Pomegranate (Punica granatum) Juice in Rabbit Experimental Animals. Jurnal Penelitian Pendidikan IPA, 9(4), 2276–2281. https://doi.org/10.29303/jppipa.v9i4.2901

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Abstract

Traditional medicines from plants (herbs) are less effective due to inappropriate doses for treatment, but are relatively safe from side effects. The purpose of this study was to determine the anthelmintic activity of red pomegranate peel extract and red pomegranate juice in rabbits as experimental animals. This research is experimental research using Completely Randomized Design (CRD) and Post Test Only Control Design approach. The population for this study were rabbits (Orytolagus cuniculus), the sample for this study were 9 rabbits aged 4-5 months with a body weight of 1.5 kg - 2 kg which were divided into two treatment groups and one control group. The results of anthelmintic activity of red pomegranate peel extract (Punica granatum L) with a dose of 100 mg/ml an average activity of 43.01%, a dose of 150 mg/ml an average activity of 100% and a dose of 200 mg/ml an average activity of 50, 9%. The results of the anthelmintic activity of red pomegranate juice (Punica granatum L) with a dose of 1 ml / kg/BW an average activity of 100%, a dose of 5 ml / kg/BW an average activity of 91.67% and a dose of 10 ml /kg/ BW average activity 58.69%.

References

Apriliani, D., Suwendar., & Fitrianingsih, S. (2022). Uji Aktivitas Antelmintik Ekstrak Etanol Kulit Buah Delima (Punica granatum L.) terhadap Cacing Gelang Babi Dewasa (Ascaris suum Goeze.) dan Telurnya Secara In Vitro. Bandung Conference Series: Pharmacy, 2(2), 231–239. https://doi.org/10.29313/bcsp.v2i2.3966

Barathikannan, K., Venkatadri, B., Khusro, A., Al-Dhabi, N. A., Agastian, P., Arasu, M. V., Choi, H. S., & Kim, Y. O. (2016). Chemical analysis of Punica granatum fruit peel and its in vitro and in vivo biological properties. BMC Complementary and Alternative Medicine, 16, 264. https://doi.org/10.1186/s12906-016-1237-3

Bizhani, N. (2015). Herbal Therapy and Treatment of Worm Infections, Emphasizing Taenia solium. Iranian Journal of Public Health, 44(11), 1555–1556.

Fong, D., & Chan, M. M. (2022). Soil-Transmitted Helminth Infections. In Human Parasites (pp. 502–527). https://doi.org/10.1142/9789811236273_0020

Gunarti;, Y Tatontos, E., & Urip. (2018). Respon Imun Pada Infeksi Kecacingan Di Wilayah Puskesmas Tanjung Karang Kota Mataram. Jurnal Kesehatan Prima, I(2), 162–168.

Horton, J. (2000). Albendazole: A review of anthelmintic efficacy and safety in humans. Parasitology, 121(SUPPL.). https://doi.org/10.1017/s0031182000007290

Indriyati, L., Annida, A., & Fakhrizal, D. (2017). Tingginya angka kecacingan pasca pengobatan massal filariasis (DEC dan Albendazole) di SDN Juku Eja Pagatan. Journal of Health Epidemiology and Communicable Diseases, 3(1), 15–21. https://doi.org/10.22435/jhecds.v3i1.1810

Jacob, J., P, R., R, G., & P, L. (2019). An Overview of Phytochemical and Pharmacological Potentials of Punica granatum L. Pharmacognosy Journal, 11, 1167–1171. https://doi.org/10.5530/pj.2019.11.181

Kartika, Q.P. (2016). Efektivitas Albendazol Triple Dose dalam Pengobatan Infeksi Cacing Usus = The Effectiveness of Triple Dose Albendazole for the Treatment of Intestinal Helminth Infections.

Kemenkes RI. (2017). Pedoman Penanggulangan Kecacingan (pp. 1–14).

Kerimi, A., Nyambe-Silavwe, H., Gauer, J. S., Tomás-Barberán, F. A., & Williamson, G. (2017). Pomegranate juice, but not an extract, confers a lower glycemic response on a high–glycemic index food: randomized, crossover, controlled trials in healthy subjects. The American Journal of Clinical Nutrition, 106(6), 1384–1393. https://doi.org/10.3945/ajcn.117.161968

Leena, D., Devidas, B., & Vikas, N. (2016). Study of Anthelmintic and Antimicrobial Activity of Peel Extract of Punica Granatum Linn.

McSorley, H. J., & Maizels, R. M. (2012). Helminth infections and host immune regulation. Clinical Microbiology Reviews, 25(4), 585–608. https://doi.org/10.1128/CMR.05040-11

Méndez-Samperio, P. (2012). Immunological mechanisms by which concomitant helminth infections predispose to the development of human tuberculosis. The Korean Journal of Parasitology, 50(4), 281–286. https://doi.org/10.3347/kjp.2012.50.4.281

Mir, M. M., Umar, I., Mir, S. A., Rehma, M. U., Rather, G. H., & Banday, S. A. (2012). Quality evaluation of pomegranate crop -A review. International Journal of Agriculture and Biology, 14(4), 658–667.

Murni, A., Malelak, D., Bagus, I., Oka, M., Sudira, W., Profesi, M. P., & Hewan, D. (2015). Ekstrak Metanol Daun Pepaya Efektif sebagai Vermisidal dan Ovisidal terhadap Cacing Ascaris Suum secara In Vitro. Indonesia Medicus Veterinus Juni, 4(3), 195–204.

Mutiara, H., Parasitologi, B., Kedokteran, F., & Lampung, U. (2015). Imunitas pada Infeksi Cacing Usus Immunity in Intestinal Worm Infection. Prosiding Seminar Presentasi Artikel Ilmiah Dies Natalis FK Unila Ke 13 |, 94–99.

Nursiyah. (2013). Studi Deskriptif Tanaman Obat Tradisional yang Digunakan Orang Tua untuk Kesehatan Anak Usia Dini di Gugus Melati Kecamatan Kalijajar Kabupaten Wonosobo. In Repository Universitas Semarang.

Partridge, F. A., Forman, R., Bataille, C. J. R., Wynne, G. M., Nick, M., Russell, A. J., Else, K. J., & Sattelle, D. B. (2020). Anthelmintic drug discovery: target identification, screening methods and the role of open science. Beilstein Journal of Organic Chemistry, 16, 1203–1224. https://doi.org/10.3762/bjoc.16.105

Reshanleksmana, Ershandi;Y Tatontos, Erlin; Inayati, N. (2011). Prevalensi Kecacingan di Lingkungan Batu Dawe Kelurahan Tanjung Karang Ampenan. Media Bina Ilmiah, 10(9), 76–79.

Seeram, N. P., Zhang, Y., McKeever, R., Henning, S. M., Lee, R., Suchard, M. A., Li, Z., Chen, S., Thames, G., Zerlin, A., Nguyen, M., Wang, D., Dreher, M., & Heber, D. (2008). Pomegranate juice and extracts provide similar levels of plasma and urinary ellagitannin metabolites in human subjects. Journal of Medicinal Food, 11(2), 390–394. https://doi.org/10.1089/jmf.2007.650

Tee, M. Z., Lee, S. C., Er, Y. X., Yap, N. J., Ngui, R., Easton, A. V., Siow, V. W. Y., Ng, K. S., Boey, C. C. M., Chua, K. H., Cadwell, K., Loke, P., & Lim, Y. A. L. (2022). Efficacy of triple dose albendazole treatment for soil-transmitted helminth infections. PLoS ONE, 17(8 August), 1–21. https://doi.org/10.1371/journal.pone.0272821

Tumiwa Meivie Jeanne, Kandou Grace Debbie, & Johnson, K. B. (2021). Aspek Nonfarmakologis Pengobatan Albendazol Pada Cacingan: Review Sistematis. Indonesian Journal of Public Health and Community Medicine, 2(2), 1–13.

Y. Swarnakar, M. Shroff, Devendra Sahu, K. D. (2013). Research Article Evaluation of Anthelmintic Potential in Fruit Peel of Punica granatum Linn.

Yones, D. A., Badary, D. M., Sayed, H. M. B., Bayoumi, S. A. H., Khalifa, A. A., & El-Moghazy, A. M. (2016). Comparative Evaluation of Anthelmintic Activity of Edible and Ornamental Pomegranate Ethanolic Extracts against Schistosoma mansoni. BioMed Research International, 2016, 2872708. https://doi.org/10.1155/2016/2872708

Author Biographies

Erna Kristinawati, Poltekkes Kemenkes Mataram

Erlin Yustin Tatontos, Poltekkes Kemenkes Mataram

Zainal Fikri , Poltekkes Kemenkes Mataram

Urip Urip, Poltekkes Kemenkes Mataram

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Copyright (c) 2023 Erna Kristinawati, Erlin Yustin Tatontos, Zainal Fikri , Urip Urip

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