Toothpaste Formulation Ethanol Extract Mangosteen Peel (Garcinia mangostana L.) and Test Activity Against Candida albicans

Authors

Nur Khairun Nisa Junuda , Ermina Pakki , Nur Ida

DOI:

10.29303/jppipa.v9i6.3623

Published:

2023-06-25

Issue:

Vol. 9 No. 6 (2023): June

Keywords:

Antifungals, Candidiasis, Candida albicans, Mangosteen peel, Toothpastes

Research Articles

Downloads

How to Cite

Junuda, N. K. N. ., Pakki, E., & Ida, N. . (2023). Toothpaste Formulation Ethanol Extract Mangosteen Peel (Garcinia mangostana L.) and Test Activity Against Candida albicans. Jurnal Penelitian Pendidikan IPA, 9(6), 4705–4710. https://doi.org/10.29303/jppipa.v9i6.3623

Downloads

Download data is not yet available.

Metrics

Metrics Loading ...

Abstract

The mangosteen peel contains phenol compounds that have antifungal activity. The study aimed to find out the antifungal activity in the dosage form of toothpaste against Candida albicans. The research methods used include the extraction of mangosteen peel (Garcinia mangostana L.) by maceration using 96% ethanol. The toothpaste formula was composed with an extract concentration of 1.25% (F1); 2.5% (F2); 5% (F3); and base (B). Antifungal testing was carried out by diffusion method using Potato Dextrose Agar (PDA) media. The results showed that the toothpaste formula with a concentration of F1; F2; F3; and base (B) has an average value of successive inhibition zone diameters of 11.86 mm; 12.03mm; 12.54mm; and 7.78 mm. The conclusion of the study showed that the toothpaste preparation of the ethanol extract of mangosteen fruit peel (Garcinia mangostana L.) concentration was 1.25%; 2.5%; 5% which performs antifungal activity.

References

Adugna, B. Y., Adinew, G. M., Getahun, K. A., Gurmu, A. E., Berhie, A. Y., Awoke, T., & Tessema Desta, G. (2022). Evaluation of the Antidiabetic Activity of Hydromethanolic Roots Extracts of Rumex abyssinicus Jacq: (Polygonaceae) in Swiss Albino Mice. Evidence-Based Complementary and Alternative Medicine, 2022, 1–11. https://doi.org/10.1155/2022/5193250

Behiry, S. I., Okla, M. K., Alamri, S. A., El-Hefny, M., Salem, M. Z., Alaraidh, I. A., & Salem, A. Z. (2019). Antifungal and antibacterial activities of Musa paradisiaca L. peel extract: HPLC analysis of phenolic and flavonoid contents. Processes, 7(4), 215. https://doi.org/10.3390/pr7040215

Boukhennoufa, A., Meddah, A. T. T., Meddah, B., & Sonnet, P. (2019). Comparative study of Artemisia herba alba asso and citrus aurantium essential oils. Journal of Microbiology, Biotechnology and Food Sciences, 9(3), 622–627. https://doi.org/10.15414/jmbfs.2019/20.9.3.622-627

Cao, M., Ming, X., Yin, H., & Li, L. (2019). Influence of high temperature on strength, ultrasonic velocity and mass loss of calcium carbonate whisker reinforced cement paste. Composites Part B: Engineering, 163, 438–446. https://doi.org/10.1016/j.compositesb.2019.01.030

Carr, E. C., Barton, Q., Grambo, S., Sullivan, M., Renfro, C. M., Kuo, A., & Harris, S. D. (2023). Characterization of a novel polyextremotolerant fungus, Exophiala viscosa, with insights into its melanin regulation and ecological niche. G3: Genes, Genomes, Genetics, jkad110. https://doi.org/10.1093/g3journal/jkad110

Christoper, W., Natalia, D., & Rahmayanti, S. (2018). Uji Aktivitas Antijamur Ekstrak Etanol Umbi Bawang Dayak (Eleutherine americana (Aubl.) Merr. Ex K. Heyne.) terhadap Trichophyton mentagrophytes secara In Vitro. Jurnal Kesehatan Andalas, 6(3). https://doi.org/10.25077/jka.v6i3.758

El Nahrawy, A. M., Elzwawy, A., Alam, M. M., Hemdan, B. A., Asiri, A. M., Karim, M. R., Hammad, A. B. A., & Rahman, M. M. (2021). Synthesis, structural analysis, electrochemical and antimicrobial activities of copper magnesium zirconosilicate (Cu20Mg10Si40Zr(30-x)O:(x = 0,5,7,10) Ni2+) nanocrystals. Microchemical Journal, 163, 105881. https://doi.org/10.1016/j.microc.2020.105881

Elsbury, D., Peings, Y., & Magnusdottir, G. (2021). Variation in the Holton–Tan effect by longitude. Quarterly Journal of the Royal Meteorological Society, 147(736), 1767–1787. https://doi.org/10.1002/qj.3993

He, X., Yang, D. P., Zhang, X., Liu, M., Kang, Z., Lin, C., & Luque, R. (2019). Waste eggshell membrane-templated CuO-ZnO nanocomposites with enhanced adsorption, catalysis and antibacterial properties for water purification. Chemical Engineering Journal, 369, 621–633. https://doi.org/10.1016/j.cej.2019.03.047

Herwin, H. (2022). Production of kombucha from Muntingia calabura L. leaves and evaluation of its antibacterial activity and total flavonoid content. Journal of Applied Pharmaceutical Science, 12(8), 187–192. https://doi.org/10.7324/JAPS.2022.120819

Hsu, H., Sheth, C. C., & Veses, V. (2021). Herbal extracts with antifungal activity against Candida albicans: A systematic review. Mini Reviews in Medicinal Chemistry, 21(1), 90–117. https://doi.org/10.2174/1389557520666200628032116

Kapila, Y. L. (2021). Oral health’s inextricable connection to systemic health: Special populations bring to bear multimodal relationships and factors connecting periodontal disease to systemic diseases and conditions. Periodontology, 87(1), 11–16. https://doi.org/10.1111/prd.12398

Kar, M., Chourasiya, Y., Maheshwari, R., & Tekade, R. K. (2019). Current developments in excipient science: implication of quantitative selection of each excipient in product development. In Basic fundamentals of drug delivery (pp. 29–83). Academic Press. https://doi.org/10.1016/B978-0-12-817909-3.00002-9

Khusnul, K., Kusmiati, M., Nurpalah, R., Aryantha, I. N. P., & Kartawinata, T. G. (2022). Effect of ethanol extract of Ganoderma lucidum from Tasikmalaya against the growth of Salmonella sp bacteria and some Pathogenic Fungi using the Kirby-Bauer method in vitro. Jurnal Kesehatan Bakti Tunas Husada: Jurnal Ilmu-Ilmu Keperawatan, Analis Kesehatan Dan Farmasi, 22(2), 168. https://doi.org/10.36465/jkbth.v22i2.956

Killilea, D. W., & Schultz, K. (2023). Pre-analytical variables influence zinc measurement in blood samples: Vol. medRxiv (pp. 2023–01). https://doi.org/10.1101/2023.01.12.23284491

Kossioni, A. E., Hajto-Bryk, J., Janssens, B., Maggi, S., Marchini, L., McKenna, G., & Zarzecka, J. (2018). Practical guidelines for physicians in promoting oral health in frail older adults. Journal of the American Medical Directors Association, 19(12), 1039–1046. https://doi.org/10.1016/j.jamda.2018.10.007

Kurniawan, Y. S., Fahmi, M. R. G., & Yuliati, L. (2020). Isolation and optical properties of natural pigments from purple mangosteen peels. IOP Conference Series: Materials Science and Engineering, 833(1), 12018. https://doi.org/10.1088/1757-899X/833/1/012018

Lestari, R., Admi, M., Rastina, R., Dewi, M., Nurliana, N., Harris, A., & Riady, G. (2020). The Isolation of Staphylococcus Epidermidis Bacteria in White Snapper Salted Fish (Lates Calcalifer) of Sibolga City, North Sumatera Province. J-Kesmas: Jurnal Fakultas Kesehatan Masyarakat (The Indonesian Journal of Public Health), 7(1), 44–50. https://doi.org/10.35308/j-kesmas.v7i1.1918

Pensantes-Sangay, S. J., Calla-Poma, R. D., Requena-Mendizabal, M. F., Alvino-Vales, M. I., & Millones-Gómez, P. A. (2020). Chemical Composition and Antibacterial Effect of Plantago Major Extract on Periodontal Pathogens. Pesquisa Brasileira Em Odontopediatria e Clínica Integrada, 20. https://doi.org/10.1590/pboci.2020.100

Puhalsky, Y. V, Loskutov, S. I., Vorobyov, N. I., Shaposhnikov, A. I., Chukaeva, M. A., Nagornov, D. O., & Kozhemyakov, A. P. (2023). Impact of Heavy Metals on Changes in the Biochemical Profile of Pea Root Exometabolites. Russian Agricultural Sciences, 49(2), 189–201. https://doi.org/10.3103/S106836742302009X

Raison, H., Corcoran, R., & Harris, R. V. (2021). Is toothbrushing behaviour habitual? Cues, context, motivators and patient narratives. Community Dentistry and Oral Epidemiology, 49(5), 478–486. https://doi.org/10.1111/cdoe.12624

Salzman, S., Crook, D., Crall, J. D., Hopkins, R., & Pierce, N. E. (2020). An ancient push-pull pollination mechanism in cycads. Science Advances, 6(24), 6169. https://doi.org/10.1126/sciadv.aay6169

Serra, E., Hidalgo-Bastida, L. A., Verran, J., Williams, D., & Malic, S. (2018). Antifungal activity of commercial essential oils and biocides against Candida albicans. Pathogens, 7(1), 15. https://doi.org/10.3390/pathogens7010015

Sulastri, E., Zubair, M. S., Anas, N. I., Abidin, S., Hardani, R., & Yulianti, R. (2018). Total phenolic, total flavonoid, quercetin content and antioxidant activity of standardized extract of Moringa oleifera leaf from regions with different elevation. Pharmacognosy Journal, 10(6s). https://doi.org/10.5530/pj.2018.6s.20

Tamiji, T., & Nezamzadeh-Ejhieh, A. (2019). Electrocatalytic behavior of AgBr NPs as modifier of carbon past electrode in the presence of methanol and ethanol in aqueous solution: a kinetic study. Journal of the Taiwan Institute of Chemical Engineers, 104, 130–138. https://doi.org/10.1016/j.foodhyd.2019.05.054

Wang, H., Shi, Y., Wang, D., Yao, Z., Wang, Y., Liu, J., & Wang, A. (2018). A biocontrol strain of Bacillus subtilis WXCDD105 used to control tomato Botrytis cinerea and Cladosporium fulvum Cooke and promote the growth of seedlings. International Journal of Molecular Sciences, 19(5), 1371. https://doi.org/10.3390/ijms19051371

Author Biographies

Nur Khairun Nisa Junuda, STIKes Karsa Husada Garut, Jawa Barat, Indonesia

Ermina Pakki, Islamic University of Makassar

Nur Ida, Islamic University of Makassar

License

Copyright (c) 2023 Nur Khairun Nisa Junuda; Ermin Pakki; Nur Ida

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Authors who publish with Jurnal Penelitian Pendidikan IPA, agree to the following terms:

  1. Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution 4.0 International License (CC-BY License). This license allows authors to use all articles, data sets, graphics, and appendices in data mining applications, search engines, web sites, blogs, and other platforms by providing an appropriate reference. The journal allows the author(s) to hold the copyright without restrictions and will retain publishing rights without restrictions.
  2. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in Jurnal Penelitian Pendidikan IPA.
  3. Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).