Effects of Stem Cell Therapy on Keloid Treatment: A Literature Review
DOI:
10.29303/jppipa.v10i6.3865Published:
2024-06-30Downloads
Abstract
Fibroblasts that produce excess collagen and growth factors play a role in the pathogenesis of keloid formation. In general, keloids are treated with intralesional corticosteroids alone or with a combination of other modalities, but the recurrence rate is still relatively high, so alternative treatments such as stem cells are being investigated, one of which is Mesenchymal Stem Cells (MSC), which have proven to be useful in healing keloids. Therefore, this literature review aims to discuss the effects of stem cell therapy in the treatment of keloids. In this literature review, 36 journals were used that discussed stem cell therapy in the treatment of keloids taken from various journal sources, namely Google Scholar, Pubmed, Medline, Ebsco, Hindawi, and Cochrane which were published within the last 10 years. According to the source, MSC is divided into 2 types, namely Adipose Mesenchymal Stem Cells (AMSC) and Bone Marrow Mesenchymal Stem Cells (BMMSC). In several studies, AMSC is known to reduce the expression of TGF-β1, COL-1, and COL-2 proteins, and has been shown to inhibit the proliferation of fibroblasts in keloid patients. Whereas in the BMMSC study that was applied with Hydroxybutyl chitosan (HBC) and Arg-Gly-Asp (RGD) hydrogels for 7 days, it was shown to significantly reduce nodular collagen fibers (p<0.05). Keloids occur due to excessive production of collagen and are influenced by various factors such as age, gender, skin color, and genetics. Stem cell therapy, such as MSC, has been proven in various studies to be an alternative treatment for keloids
Keywords:
Keloid treatment, Review, Stem cell therapyReferences
Bojanic, C., To, K., Hatoum, A., Jessie Shea, K. T. M. S., Khan, W., & Malata, C. M. (2021). Mesenchymal Stem Cell Therapy in Hypertrophic and Keloid Scars. Cell and Tissue Research, 383(3), 915–930. https://doi.org/10.1007/S00441-020-03361-Z/TABLES/4.
Chen, H., Hou, K., Wu, Y., & Liu, Z. (2022). Use of Adipose Stem Cells Against Hypertrophic Scarring or Keloid. Frontiers in Cell and Developmental Biology, 9. https://doi.org/10.3389/fcell.2021.823694
Elsaie, M. L. (2021). Update on management of keloid and hypertrophic scars: A systemic review. Journal of Cosmetic Dermatology, 20(9), 2729–2738. https://doi.org/10.1111/jocd.14310
Fang, F., Huang, R.-L., Zheng, Y., Liu, M., & Huo, R. (2016). Bone marrow derived mesenchymal stem cells inhibit the proliferative and profibrotic phenotype of hypertrophic scar fibroblasts and keloid fibroblasts through paracrine signaling. Journal of Dermatological Science, 83(2), 95–105. https://doi.org/10.1016/j.jdermsci.2016.03.003
Heo, J. S., Choi, Y., & Kim, H. O. (2019). Adipose-Derived Mesenchymal Stem Cells Promote M2 Macrophage Phenotype through Exosomes. Stem Cells International, 2019, 1–10. https://doi.org/10.1155/2019/7921760
Hu, M. S., Leavitt, T., Malhotra, S., Duscher, D., Pollhammer, M. S., Walmsley, G. G., Maan, Z. N., Cheung, A. T. M., Schmidt, M., Huemer, G. M., Longaker, M. T., & Lorenz, H. P. (2015). Stem Cell-Based Therapeutics to Improve Wound Healing. Plastic Surgery International, 2015, 1–7. https://doi.org/10.1155/2015/383581
Huang, C., Wu, Z., Du, Y., & Ogawa, R. (2020). The Epidemiology of Keloids. In Textbook on Scar Management (pp. 29–35). Springer International Publishing. https://doi.org/10.1007/978-3-030-44766-3_4
Khandpur, S., Gupta, S., & Gunaabalaji, D. R. (2021). Stem cell therapy in dermatology. Indian Journal of Dermatology, Venereology and Leprology, 87(6), 753. https://doi.org/10.25259/IJDVL_19_20
Li, J., Li, Z., Wang, S., Bi, J., & Huo, R. (2022). Exosomes from human adipose-derived mesenchymal stem cells inhibit production of extracellular matrix in keloid fibroblasts via downregulating transforming growth factor-β2 and Notch-1 expression. Bioengineered, 13(4), 8515–8525. https://doi.org/10.1080/21655979.2022.2051838
Lim, K. H., Itinteang, T., Davis, P. F., & Tan, S. T. (2019). Stem Cells in Keloid Lesions: A Review. Plastic and Reconstructive Surgery - Global Open, 7(5), e2228. https://doi.org/10.1097/GOX.0000000000002228
Liu, J., Ren, J., Su, L., Cheng, S., Zhou, J., Ye, X., Dong, Y., Sun, S., Qi, F., Liu, Z., Pleat, J., Zhai, H., & Zhu, N. (2018). Human adipose tissue-derived stem cells inhibit the activity of keloid fibroblasts and fibrosis in a keloid model by paracrine signaling. Burns, 44(2), 370–385. https://doi.org/10.1016/j.burns.2017.08.017
Luan, A., Duscher, D., Whittam, A. J., Paik, K. J., Zielins, E. R., Brett, E. A., Atashroo, D. A., Hu, M. S., Lee, G. K., Gurtner, G. C., Longaker, M. T., & Wan, D. C. (2016). Cell-Assisted Lipotransfer Improves Volume Retention in Irradiated Recipient Sites and Rescues Radiation-Induced Skin Changes. Stem Cells, 34(3), 668–673. https://doi.org/10.1002/stem.2256
Manoharan, A., & Rao, S. M. (2020). Analysis of risk factors behind keloid. International Journal of Research in Dermatology, 6(2), 138. https://doi.org/10.18203/issn.2455-4529.IntJResDermatol20200011
McGinty, S., & Siddiqui, W. J. (2022). Keloid. Pubmed.
Menaldi, S. L. S. W., Bramono, K., & Indriatmi, W. (2016). Ilmu Penyakit Kulit dan Kelamin. Edisi Ketu. Fakultas Kedokteran Universitas Indonesia.
Nangole, F. W., & Agak, G. W. (2019). Keloid pathophysiology: fibroblast or inflammatory disorders? JPRAS Open, 22, 44–54. https://doi.org/10.1016/j.jpra.2019.09.004
Ojeh, N., Bharatha, A., Gaur, U., & Forde, A. L. (2020). Keloids: Current and emerging therapies. Scars, Burns & Healing, 6. https://doi.org/10.1177/2059513120940499
Qu, C., Bao, Z., Zhang, X., Wang, Z., Ren, J., Zhou, Z., Tian, M., Cheng, X., Chen, X., & Feng, C. (2019). A thermosensitive RGD-modified hydroxybutyl chitosan hydrogel as a 3D scaffold for BMSCs culture on keloid treatment. International Journal of Biological Macromolecules, 125, 78–86. https://doi.org/10.1016/j.ijbiomac.2018.12.058
Seo, B. F., & Jung, S.-N. (2016). The Immunomodulatory Effects of Mesenchymal Stem Cells in Prevention or Treatment of Excessive Scars. Stem Cells International, 2016, 1–8. https://doi.org/10.1155/2016/6937976
Shaheen, A. A. (2017). Risk Factors of Keloids: A Mini Review. Austin Journal of Dermatology, 4(2). https://doi.org/10.26420/austinjdermatolog.2017.1074
Wang, H., Li, Y., Yue, Z., Liu, Y., Chen, Q., Hu, D., & Han, J. (2022). Adipose-Derived Stem Cell Exosomes Inhibit Hypertrophic Scaring Formation by Regulating Th17/Treg Cell Balance. BioMed Research International, 2022, 1–12. https://doi.org/10.1155/2022/9899135
Wang, X., Ma, Y., Gao, Z., & Yang, J. (2018). Human adipose-derived stem cells inhibit bioactivity of keloid fibroblasts. Stem Cell Research & Therapy, 9(1), 40. https://doi.org/10.1186/s13287-018-0786-4
Xie, F., Teng, L., Xu, J., Lu, J., Zhang, C., Yang, L., Ma, X., & Zhao, M. (2020). Adipose‑derived mesenchymal stem cells inhibit cell proliferation and migration and suppress extracellular matrix synthesis in hypertrophic‑scar and keloid fibroblasts. Experimental and Therapeutic Medicine, 21(2), 139. https://doi.org/10.3892/etm.2020.9571
Xiong, M., Zhang, Q., Hu, W., Zhao, C., Lv, W., Yi, Y., Wu, Y., & Wu, M. (2020). Exosomes From Adipose-Derived Stem Cells: The Emerging Roles and Applications in Tissue Regeneration of Plastic and Cosmetic Surgery. Frontiers in Cell and Developmental Biology, 8. https://doi.org/10.3389/fcell.2020.574223
Xu, J.-H., Xu, S.-Q., Ding, S.-L., Yang, H., Huang, X., & Shi, H.-F. (2022). Bone marrow mesenchymal stem cells alleviate the formation of pathological scars in rats. Regenerative Therapy, 20, 86–94. https://doi.org/10.1016/j.reth.2022.03.004
Yang, J., Li, S., He, L., & Chen, M. (2021). Adipose-derived stem cells inhibit dermal fibroblast growth and induce apoptosis in keloids through the arachidonic acid-derived cyclooxygenase-2/prostaglandin E2 cascade by paracrine. Burns & Trauma, 9. https://doi.org/10.1093/burnst/tkab020
Zahorec, P., Sarkozyova, N., Ferancikova, N., Bukovcan, P., Danisovic, L., Bohac, M., Tomas, M., & Koller, J. (2021). Autologous Mesenchymal Stem Cells Application in Post-Burn Scars Treatment: a Preliminary Study. Cell and Tissue Banking, 22(1), 39–46. https://doi.org/10.1007/S10561-020-09862-Z/METRICS.
Zhou, J., Shen, J.-Y., Tao, L.-E., & Chen, H. (2022). The Inhibition of Adipose-Derived Stem Cells on the Invasion of Keloid Fibroblasts. International Journal of Medical Sciences, 19(12), 1796–1805. https://doi.org/10.7150/ijms.68646
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