Assessment of Metformin Stability and Its Removal from Water by Pumice-Based Zeolite
DOI:
10.29303/jppipa.v9i7.3965Published:
2023-07-25Issue:
Vol. 9 No. 7 (2023): JulyKeywords:
Adsorption, Environmental Science, Metformin, Pumice, ZeoliteResearch Articles
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Abstract
Metformin (MET) is an emerging contaminant often found in aquatic environments due to incompletely metabolized after consumption in the human body, where some of its doses are excreted in unchanged form through urine or faeces. The research aims are to study MET stability in water and to evaluate the potential of pumice-based zeolite for treating MET contaminants. Zeolites were prepared from pumice via the hydrothermal treatment and characterized using Fourier Transform Infrared (FTIR) and X-Ray Diffraction (XRD). A simple spectrophotometric method was proposed for determining the stability of MET in aqueous solution with several different conditions. The result showed that the metformin solution was unstable under strong acid conditions (pH 2), marked by the loss of the maximum absorption peak in the 220-250 nm range. The stable metformin conditions in this study were obtained at the pH of solutions ranging from 6 to 10 and temperatures between 14 oC to 40 oC. Furthermore, the stability of MET can be maintained for up to 3 days of exposure time. Based on the adsorption result, zeolite uptake capacity (196 µg/g) was higher than pumice (87 µg/g) to reduce metformin concentration. In addition, the synthesized zeolite needs further modification to increase its adsorption performance.
References
Adegoke, K. A., Olagunju, A. O., Alagbada, T. C., Alao, O. C., Adesina, M. O., Afolabi, I. C., Adegoke, R. O., & Bello, O. S. (2022). Adsorptive removal of endocrine-disrupting chemicals from aqueous solutions: a review. Water, Air, & Soil Pollution, 233(2), 38. https://doi.org/10.1007/s11270-021-05405-8
Balakrishnan, A., Sillanpää, M., Jacob, M. M., & Vo, D. V. N. (2022). Metformin as an emerging concern in wastewater: Occurrence, analysis and treatment methods. Environmental Research, 213, 113613. https://doi.org/10.1016/j.envres.2022.113613
Bojanić, I., Bjerkeset, O., Williams, L. J., Berk, M., Bjørngaard, J. H., Sund, E. R., & Sletvold, H. (2023). Risk of antidepressant initiation among users of cardiovascular agents and metformin. Findings from the Trøndelag Health Study (HUNT) and Norwegian Prescription Database (NorPD), Norway. Pharmacology Research & Perspectives, 11(2), e01078. https://doi.org/10.1002/prp2.1078
Demiral, Ä°., Samdan, C., & Demiral, H. (2021). Enrichment of the surface functional groups of activated carbon by modification method. Surfaces and Interfaces, 22, 100873. https://doi.org/10.1016/j.surfin.2020.100873
El-Fattah, A., Maged, A., Kamel, R. M., & Kharbish, S. (2023). Recent Technologies for The Elimination of Pharmaceutical Compounds from aqueous solutions: A review. Frontiers in Scientific Research and Technology, 5(1). https://doi.org/10.21608/FSRT.2023.173676.1074
Ersoy, B., Sariisik, A., Dikmen, S., & Sariisik, G. (2010). Characterization of acidic pumice and determination of its electrokinetic properties in water. Powder Technology, 197, 129-135. https://doi.org/10.1016/j.powtec.2009.09.005
Fast, S. A., Gude, V. G., Truax, D. D., Martin, J., & Magbanua, B. S. (2017). A critical evaluation of advanced oxidation processes for emerging contaminants removal. Environmental Processes, 4, 283-302. https://doi.org/10.1007/s40710-017-0207-1
Gu, Y., Zhang, Y., Jiang, C., Dong, Z., & Bai, X. (2023). Efficient metformin transformation in sulfite/UV process co-present with oxygen. Frontiers in Environmental Science, 10, 1071963. https://doi.org/10.3389/fenvs.2022.1071963
Kalumpha, M., Guyo, U., Zinyama, N. P., Vakira, F. M., & Nyamunda, B. C. (2020). Adsorptive potential of Zea mays tassel activated carbon towards the removal of metformin hydrochloride from pharmaceutical effluent. International journal of phytoremediation, 22(2), 148-156. https://doi.org/10.1080/15226514.2019.1652561
Kim, J. Y., Jeon, J., & Kim, S. D. (2023). Prioritization of pharmaceuticals and personal care products in the surface waters of Korea: Application of an optimized risk-based methods. Ecotoxicology and Environmental Safety, 259, 115024. https://doi.org/10.1016/j.ecoenv.2023.115024
Liu, H., Wang, C., & Wang, G. (2020). Photocatalytic advanced oxidation processes for water treatment: recent advances and perspective. Chemistry–An Asian Journal, 15(20), 3239-3253. https://doi.org/10.1002/asia.202000895
Majithia, R. H., Khodadiya, A., & Patel, V. B. (2020). Spectrophotometric method development and validation for simultaneous estimation of Anagliptin and Metformin HCl BY Q-Absorption ratio method in synthetic mixture. Heliyon, 6(5). https://doi.org/10.1016/j.heliyon.2020.e03855
Martinez-Alcala, I., Guillén-Navarro, J. M., & Fernández-López, C. (2017). Pharmaceutical biological degradation, sorption and mass balance determination in a conventional activated-sludge wastewater treatment plant from Murcia, Spain. Chemical Engineering Journal, 316, 332-340. https://doi.org/10.1016/j.cej.2017.01.048
Moosavi, S., Lai, C. W., Gan, S., Zamiri, G., Akbarzadeh Pivehzhani, O., & Johan, M. R. (2020). Application of efficient magnetic particles and activated carbon for dye removal from wastewater. ACS omega, 5(33). https://doi.org/10.1021/acsomega.0c01905
Nuri, O. S., Irannajad, M., & Mehdilo, A. (2019). Reagent adsorption on modified mineral surfaces: isotherm, kinetic and thermodynamic aspects. Journal of Molecular Liquids, 291, 111311. https://doi.org/10.1016/j.molliq.2019.111311
Oosterhuis, M., Sacher, F., & Ter Laak, T. L. (2013). Prediction of concentration levels of metformin and other high consumption pharmaceuticals in wastewater and regional surface water based on sales data. Science of the Total Environment, 442. https://doi.org/10.1016/j.scitotenv.2012.10.046
Prajaputra, V., Abidin, Z., Budiarti, S., & Suryaningtyas, D. T. (2021). Synergistic effect of adsorption and Fenton-like oxidation processes for methylene blue removal using Na-P1 zeolite prepared from pumice. Desalination and Water Treatment, 218(2021), 401-408. https://doi.org/10.5004/dwt.2021.26976
Prajaputra, V., Abidin, Z., Budiarti, S., Suryaningtyas, D. T., & Isnaini, N. (2021). Comparative study of methylene blue adsorption using alkali-activated pumice from Bali and Banten. Journal of Physics: Conference Series, 1882(1), 012118. http://doi.org/10.1088/1742-6596/1882/1/012118
Prajaputra, V., Abidin, Z., Suryaningtyas, D. T., & Rizal, H. (2019). Characterization of Na-P1 zeolite synthesized from pumice as low-cost materials and its ability for methylene blue adsorption. IOP Conference Series: Earth and Environmental Science, 399(1), 012014. https://doi.org/10.1088/1755-1315/399/1/012014
Ratnam, M. V., Akilamudhan, P., Kumar, K. S., Reddy, S. N., Rao, K. N., Shaik, F., & Prasad, D. M. (2023). Carbon-Based Nanoadsorbents for the Removal of Emerging Pollutants. Adsorption Science & Technology, 2023. https://doi.org/10.1155/2023/3579165
Rebecca, Y. M., Sudha, V., Bharathiraja, T., Kannan, T., Lavanya, J., & Kumar, A. K. H. (2023). Urinary excretion of metformin in diabetic patients with and without tuberculosis. Indian Journal of Tuberculosis, 70(1). https://doi.org/10.1016/j.ijtb.2022.03.004
Salovska, B., Gao, E., Müllerâ€Dott, S., Li, W., Cordon, C. C., Wang, S., Dugourd, A., Rosenberger, G., Saezâ€Rodriguez, J., & Liu, Y. (2023). Phosphoproteomic analysis of metformin signaling in colorectal cancer cells elucidates mechanism of action and potential therapeutic opportunities. Clinical and Translational Medicine, 13(2). https://doi.org/10.1002/ctm2.1179
Sayedali, E., Yalin, A. E., & Yalin, S. (2023). Association between metformin and vitamin B12 deficiency in patients with type 2 diabetes. World Journal of Diabetes, 14(5), 585-593. https://doi.org/10.4239/wjd.v14.i5.585
Sharma, V. K., Nautiyal, V., Goel, K. K., & Sharma, A. (2010). Assessment of thermal stability of metformin hydrochloride. Asian Journal of Chemistry, 22(5), 3561. Retrieved from https://asianjournalofchemistry.co.in/User/ViewFreeArticle.aspx?ArticleID=22_5_33
Sousa, M., Rodrigues, S., Pretti, C., Meucci, V., Battaglia, F., Freitas, R., & Antunes, S. C. (2023). A forecast effects of climate change and anthropogenic compounds in Gambusia holbrooki: ecotoxicological effects of salinity and metformin. Aquatic Toxicology, 258, 106494. https://doi.org/10.1016/j.aquatox.2023.106494
Toktamış, D. (2023). Thermoluminescence in pumice stone collected from the Mediterranean coast. Luminescence, 38(3), 318-325. https://doi.org/10.1002/bio.4452
Triggle, C. R., Mohammed, I., Bshesh, K., Marei, I., Ye, K., Ding, H., MacDonald, R., Hollenberg, M. D., & Hill, M. A. (2022). Metformin: Is it a drug for all reasons and diseases? Metabolism, 133, 155223. https://doi.org/10.1016/j.metabol.2022.155223
Wan Ibrahim, W. M. H., Mohamad Amini, M. H., Sulaiman, N. S., & Wan Abdul Kadir, W. R. (2021). Evaluation of alkaline-based activated carbon from Leucaena Leucocephala produced at different activation temperatures for cadmium adsorption. Applied Water Science, 11, 1-13. https://doi.org/10.1007/s13201-020-01330-z
Wu, L., Lu, X., Wu, Y., Huang, C., Gu, C., Tian, Y., & Ma, J. (2023). An electrochemical sensor based on synergistic enhancement effects between nitrogen-doped carbon nanotubes and copper ions for ultrasensitive determination of anti-diabetic metformin. Science of The Total Environment, 878. https://doi.org/10.1016/j.scitotenv.2023.163120
Author Biographies
Vicky Prajaputra, Universitas Syiah Kuala
Nadia Isnaini, Department of Pharmacy, Universitas Syiah Kuala, Indonesia
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Copyright (c) 2023 Vicky Prajaputra, Nadia Isnaini
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