Antidiabetic Activity of Ethanol-Water Fraction of Longjack Root (Eurycoma longifolia Jack.) in Streptozotocin-Nicotinamide Induced Rats

Authors

Wiwik Hartika , Michelle Terrence , Ikhsan Samir , Ruqiah Ganda Putri Panjaitan

DOI:

10.29303/jppipa.v10i2.4759

Published:

2024-02-25

Issue:

Vol. 10 No. 2 (2024): February

Keywords:

Longjack root, Blood glucose level, Diabetes mellitus, MDA levels, Pancreatic histopathology

Research Articles

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How to Cite

Hartika, W., Terrence, M., Samir, I., & Panjaitan, R. G. P. (2024). Antidiabetic Activity of Ethanol-Water Fraction of Longjack Root (Eurycoma longifolia Jack.) in Streptozotocin-Nicotinamide Induced Rats. Jurnal Penelitian Pendidikan IPA, 10(2), 776–783. https://doi.org/10.29303/jppipa.v10i2.4759

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Abstract

This study aims to determine the decrease in glucose levels, MDA levels, and histopathological appearance of the pancreatic organs of Wistar white rats after administration of the ethanol-water fraction of longjack root. This study used a completely randomized design with four treatment groups and six replications. The treatment consisted of normal control, negative control (Na-CMC 0.5% 5 ml/200 g body weight), positive control (glibenclamide 0.09 mg/200 g body weight), and treatment of the ethanol-water fraction of longjack root with a dose of 500 mg/kg body weight. The results showed that the ethanol-water fraction of longjack root at a dose of 500 mg/kg body weight had antidiabetic activity comparable to that of glibenclamide at a dose of 0.09/200 g body weight, namely blood glucose levels and MDA levels in white rats of 123.55 mg/dl and 2.83 nmol/ml. The results of histopathological analysis of the pancreas of white rats showed that administration of the ethanol-water fraction of longjack root could repair damage to the islets of Langerhans due to the administration of streptozotocin-nicotinamide.

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Author Biographies

Wiwik Hartika, Tanjungpura University

Michelle Terrence, Tanjungpura University

Ikhsan Samir, Tanjungpura University

Ruqiah Ganda Putri Panjaitan, Tanjungpura University

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Copyright (c) 2024 Wiwik Hartika, Michelle Terrence, Ikhsan Samir, Ruqiah Ganda Putri Panjaitan

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