Literature Review: Role of Vitamin D in Diabetic Foot Ulcer Wound Healing


Kemas Dahlan , Irfanuddin , Krisna Murti , Akhmadu Muradi






Vol. 9 No. 10 (2023): October


Diabetic Foot Ulcer, Diabetes Mellitus, Vitamin D, Wound Healing



How to Cite

Dahlan, K. ., Irfanuddin, Murti, K. ., & Muradi, A. . (2023). Literature Review: Role of Vitamin D in Diabetic Foot Ulcer Wound Healing. Jurnal Penelitian Pendidikan IPA, 9(10), 854–867.


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DFU is a common consequence of DM. Vitamin D has multiple positive effects on DFU. Search data from; Google Scholar, Science Direct, Elsevier, EBSCO, Medline and PubMed. Publication at least ten years (2013 until 2022). Inclusion criteria; full paper in English, Study about vitamin D and DFU in human, exclusion criteria; animal model and invitro study. Results; 27 journals; Seven Randomized Controlled Trial. Vitamin D phase on DFU which one substantially smaller. Severe vitamin D insufficiency known with significance linked for an elevated risk of DFU. Vitamin D supplementation can prevent or improve diabetic foot complications


Al-Ahmady, S. K. (2013). Study the effect of Zinc/or Vit. D3 on Percentage of Healing of Diabetic Foot Ulcer in Iraqi Patients. International Journal of Advances in Pharmacy, Biology And Chemistry, 2(4). the effect of Zincor Vit.D3 on Percentage of.pdf

Alam, U., Fawwad, A., Shaheen, F., Tahir, B., Basit, A., Malik, R. A., & others. (2017). Improvement in neuropathy specific quality of life in patients with diabetes after vitamin D supplementation. Journal of Diabetes Research, 2017.

Alexiadou, K., & Doupis, J. (2012). Management of diabetic foot ulcers. Diabetes Therapy, 3, 1–15.

Arafat, E. S., Taha, I. M., Kattan, S. W., Babteen, N. A., & Fawzy, I. (2020). Associations between vitamin D and type 2 diabetes mellitus: The role of vitamin D receptor and binding protein. Journal of Diabetes Mellitus, 10(04), 222–235.

Azizieh, F., Alyahya, K. O., & Raghupathy, R. (2016). Association between levels of vitamin D and inflammatory markers in healthy women. Journal of Inflammation Research, 51–57.

Bartley, J. (2010). Vitamin D: emerging roles in infection and immunity. Expert Review of Anti-Infective Therapy, 8(12), 1359–1369.

Çağlar, S., Çağlarr, A., Pilten, S., Albay, C., Beytemur, O., & Sari, H. (2018). Osteoprotegerin and 25-hydroxy vitamin D levels in patients with diabetic foot. Eklem Hastaliklari ve Cerrahisi= Joint Diseases & Related Surgery, 29(3), 170–175.

Dai, J., Jiang, C., Chen, H., & Chai, Y. (2019). Vitamin D and diabetic foot ulcer: a systematic review and meta-analysis. Nutrition & Diabetes, 9(1), 8.

Dashti, F., Mousavi, S. M., Larijani, B., & Esmaillzadeh, A. (2021). The effects of vitamin D supplementation on inflammatory biomarkers in patients with abnormal glucose homeostasis: A systematic review and meta-analysis of randomized controlled trials. Pharmacological Research, 170, 105727.

El Hajj, C., Walrand, S., Helou, M., & Yammine, K. (2020). Effect of vitamin D supplementation on inflammatory markers in non-obese Lebanese patients with type 2 diabetes: a randomized controlled trial. Nutrients, 12(7), 2033.

Feldkamp, J., Jungheim, K., Schott, M., Jacobs, B., & Roden, M. (2018). Severe vitamin D3 deficiency in the majority of patients with diabetic foot ulcers. Hormone and Metabolic Research, 50(08), 615–619.

Gombart, A. F., Borregaard, N., & Koeffler, H. P. (2005). Human cathelicidin antimicrobial peptide (CAMP) gene is a direct target of the vitamin D receptor and is strongly up-regulated in myeloid cells by 1, 25-dihydroxyvitamin D3. The FASEB Journal, 19(9), 1067–1077.

Greenhagen, R. M., Frykberg, R. G., & Wukich, D. K. (2019). Serum vitamin D and diabetic foot complications. Diabetic Foot & Ankle, 10(1), 1579631.

Gupta, B., Dwivedi, A., & Singh, S. K. (2017). Effect of vitamin D supplementation on cytokines expression in patients with diabetic foot infection. Indian Journal of Endocrinology & Metabolism, 21.

Halschou-Jensen, P. M., Sauer, J., Bouchelouche, P., Fabrin, J., Brorson, S., & Ohrt-Nissen, S. (2023). Improved healing of diabetic foot ulcers after high-dose vitamin D: a randomized double-blinded clinical trial. The International Journal of Lower Extremity Wounds, 22(3), 466–474.

Hewison, M. (2011). Vitamin D and innate and adaptive immunity. Vitamins & Hormones, 86, 23–62.

Ismailova, A., & White, J. H. (2022). Vitamin D, infections and immunity. Reviews in Endocrine and Metabolic Disorders, 1–13.

Kamble, A., & Swarnkar, M. (2019). A study of the prevalence and severity of vitamin D deficiency in patient with diabetic foot and its association with vascular calcification and effect on healing. International Surgery Journal, 6(5), 1654–1658.

Karonova, T., Stepanova, A., Bystrova, A., & Jude, E. B. (2020). High-dose vitamin D supplementation improves microcirculation and reduces inflammation in diabetic neuropathy patients. Nutrients, 12(9), 2518.

Khan, M. A. B., Hashim, M. J., King, J. K., Govender, R. D., Mustafa, H., & Al Kaabi, J. (2020). Epidemiology of type 2 diabetes--global burden of disease and forecasted trends. Journal of Epidemiology and Global Health, 10(1), 107.

Kinesya, E., Santoso, D., Arya, N. G., Cintya, E. P., Ambarini, P. S., Kinesya, B., Kartjito, M. S., & Mannagalli, Y. (2023). Vitamin D as adjuvant therapy for diabetic foot ulcers: Systematic review and meta-analysis approach. Clinical Nutrition ESPEN.

Kurian, S. J., Miraj, S. S., Benson, R., Munisamy, M., Saravu, K., Rodrigues, G. S., & Rao, M. (2021). Vitamin D supplementation in diabetic foot ulcers: a current perspective. Current Diabetes Reviews, 17(4), 512–521.

L Bishop, E., Ismailova, A., Dimeloe, S., Hewison, M., & White, J. H. (2021). Vitamin D and immune regulation: antibacterial, antiviral, anti-inflammatory. JBMR Plus, 5(1), e10405.

Lennarz, W. J., & Lane, M. D. (2013). Encyclopedia of biological chemistry. Academic Press.

Lin, J., Mo, X., Yang, Y., Tang, C., & Chen, J. (2023). Association between vitamin D deficiency and diabetic foot ulcer wound in diabetic subjects: A meta-analysis. International Wound Journal, 20(1), 55–62.

Macido, A. (2018). Diabetic foot ulcers and vitamin D status: a literature review. SAGE Open Nursing, 4, 2377960818789027.

Marcinowska-Suchowierska, E., Kupisz-UrbaÅ„ska, M., Åukaszkiewicz, J., & PÅ‚udowski PaweÅ‚and Jones, G. (2018). Vitamin D toxicity--a clinical perspective. Frontiers in Endocrinology, 9, 550.

Mariadoss, A. V. A., Sivakumar, A. S., Lee, C.-H., & Kim, S. J. (2022). Diabetes mellitus and diabetic foot ulcer: Etiology, biochemical and molecular based treatment strategies via gene and nanotherapy. Biomedicine & Pharmacotherapy, 151, 113134.

Martens, P.-J., Gysemans, C., Verstuyf, A., & Mathieu, C. (2020). Vitamin D’s effect on immune function. Nutrients, 12(5), 1248.

Mousa, A., Naderpoor, N., Teede, H., Scragg, R., & de Courten, B. (2018). Vitamin D supplementation for improvement of chronic low-grade inflammation in patients with type 2 diabetes: a systematic review and meta-analysis of randomized controlled trials. Nutrition Reviews, 76(5), 380–394.

Mozaffari-Khosravi, H., Haratian-Arab, M., Tavakkoli, H. M., & Nadjarzadeh, A. (2016). Comparative effect of two different doses of vitamin D on diabetic foot ulcer and inflammatory indices among the type 2 diabetic patients: a randomized clinical trial. Iranian Journal of Diabetes and Obesity, 8(4), 164–171.

Putz, Z., Tordai, D., Hajdú, N., Vági, O. E., Kempler, M., Békeffy, M., Körei, A. E., Istenes, I., Horváth, V., Stoian, A. P., & others. (2022). Vitamin D in the prevention and treatment of diabetic neuropathy. Clinical Therapeutics, 44(5), 813–823.

Ramasamy, I. (2020). Vitamin D metabolism and guidelines for vitamin D supplementation. The Clinical Biochemist Reviews, 41(3), 103.

Razzaghi, R., Pourbagheri, H., Momen-Heravi, M., Bahmani, F., Shadi, J., Soleimani, Z., & Asemi, Z. (2017). The effects of vitamin D supplementation on wound healing and metabolic status in patients with diabetic foot ulcer: a randomized, double-blind, placebo-controlled trial. Journal of Diabetes and Its Complications, 31(4), 766–772.

Schauber, J., & Gallo, R. L. (2008). The vitamin D pathway: a new target for control of the skin’s immune response? Experimental Dermatology, 17(8), 633–639.

Smith, K., & Hewlings, S. (2021). Correlation between vitamin D levels and hard-to-heal wounds: a systematic review. Journal of Wound Care, 30(Sup6), S4--S10.

Tang, Y., Huang, Y., Luo, L., Xu, M., Deng, D., Fang, Z., Zhao, X., & Chen, M. (2023). Level of 25-hydroxyvitamin D and vitamin D receptor in diabetic foot ulcer and factor associated with diabetic foot ulcers. Diabetology & Metabolic Syndrome, 15(1), 30.

Tiwari, S., Pratyush, D. D., Gupta, S. K., & Singh, S. K. (2014). Vitamin D deficiency is associated with inflammatory cytokine concentrations in patients with diabetic foot infection. British Journal of Nutrition, 112(12), 1938–1943.

Urbanovych, A. M., & Shykula, S. I. (2022). Vitamin D and diabetes mellitus. International Journal Of Endocrinology (Ukraine), 18(1), 78–83.

Wang, F., Zhou, L., Zhu, D., & Yang, C. (2022). A retrospective analysis of the relationship between 25-OH-vitamin D and diabetic foot ulcer. Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy, 1347–1355.

Wang, Y., Zhu, J., & DeLuca, H. F. (2012). Where is the vitamin D receptor? Archives of Biochemistry and Biophysics, 523(1), 123–133.

Wu, C., Qiu, S., Zhu, X., & Li, L. (2017). Vitamin D supplementation and glycemic control in type 2 diabetes patients: A systematic review and meta-analysis. Metabolism, 73, 67–76.

Yamada, S., Shimizu, M., & Yamamoto, K. (2003). Vitamin D receptor. Endocrine Development, 6, 50–68.

Yammine, K., Hayek, F., & Assi, C. (2020). Is there an association between vitamin D and diabetic foot disease? A meta-analysis. Wound Repair and Regeneration, 28(1), 90–96.

Zhang, P., Lu, J., Jing, Y., Tang, S., Zhu, D., & Bi, Y. (2017). Global epidemiology of diabetic foot ulceration: a systematic review and meta-analysis. Annals of Medicine, 49(2), 106–116.

Author Biographies

Kemas Dahlan, Faculty of Medicine University of Sriwijaya

Irfanuddin, Faculty of Medicine University of Sriwijaya

Krisna Murti, Faculty of Medicine University of Sriwijaya

Akhmadu Muradi, Faculty of Medicine University of Indonesia


Copyright (c) 2023 Kemas Dahlan, Irfanuddin, Krisna Murti, Akhmadu Muradi

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