Literature Review: Role of Vitamin D in Diabetic Foot Ulcer Wound Healing
DOI:
10.29303/jppipa.v9i10.5135Published:
2023-10-25Downloads
Abstract
DFU is a common consequence of DM. Vitamin D has multiple positive effects on DFU. Search data from; Google Scholar, Science Direct, Elsevier, EBSCO, Medline and PubMed. Publication at least ten years (2013 until 2022). Inclusion criteria; full paper in English, Study about vitamin D and DFU in human, exclusion criteria; animal model and invitro study. Results; 27 journals; Seven Randomized Controlled Trial. Vitamin D phase on DFU which one substantially smaller. Severe vitamin D insufficiency known with significance linked for an elevated risk of DFU. Vitamin D supplementation can prevent or improve diabetic foot complications
Keywords:
Diabetic Foot Ulcer Diabetes Mellitus Vitamin D Wound HealingReferences
Al-Ahmady, S. K. (2013). Study the effect of Zinc/or Vit. D3 on Percentage of Healing of Diabetic Foot Ulcer in Iraqi Patients. International Journal of Advances in Pharmacy, Biology And Chemistry, 2(4). https://www.pharmacy.uobasrah.edu.iq/images/Research_dr/dr_noor_mohammed/Study the effect of Zincor Vit.D3 on Percentage of.pdf
Alam, U., Fawwad, A., Shaheen, F., Tahir, B., Basit, A., Malik, R. A., & others. (2017). Improvement in neuropathy specific quality of life in patients with diabetes after vitamin D supplementation. Journal of Diabetes Research, 2017. https://doi.org/10.1155/2017/7928083
Alexiadou, K., & Doupis, J. (2012). Management of diabetic foot ulcers. Diabetes Therapy, 3, 1–15. https://doi.org/10.1007/s13300-012-0004-9
Arafat, E. S., Taha, I. M., Kattan, S. W., Babteen, N. A., & Fawzy, I. (2020). Associations between vitamin D and type 2 diabetes mellitus: The role of vitamin D receptor and binding protein. Journal of Diabetes Mellitus, 10(04), 222–235. https://doi.org/10.4236/jdm.2020.104018
Azizieh, F., Alyahya, K. O., & Raghupathy, R. (2016). Association between levels of vitamin D and inflammatory markers in healthy women. Journal of Inflammation Research, 51–57. https://doi.org/10.2147/JIR.S103298
Bartley, J. (2010). Vitamin D: emerging roles in infection and immunity. Expert Review of Anti-Infective Therapy, 8(12), 1359–1369. https://doi.org/10.1586/eri.10.102
Çağlar, S., Çağlarr, A., Pilten, S., Albay, C., Beytemur, O., & Sari, H. (2018). Osteoprotegerin and 25-hydroxy vitamin D levels in patients with diabetic foot. Eklem Hastaliklari ve Cerrahisi= Joint Diseases & Related Surgery, 29(3), 170–175. https://doi.org/10.5606/ehc.2018.60797
Dai, J., Jiang, C., Chen, H., & Chai, Y. (2019). Vitamin D and diabetic foot ulcer: a systematic review and meta-analysis. Nutrition & Diabetes, 9(1), 8. https://www.nature.com/articles/s41387-019-0078-9
Dashti, F., Mousavi, S. M., Larijani, B., & Esmaillzadeh, A. (2021). The effects of vitamin D supplementation on inflammatory biomarkers in patients with abnormal glucose homeostasis: A systematic review and meta-analysis of randomized controlled trials. Pharmacological Research, 170, 105727. https://doi.org/10.1016/j.phrs.2021.105727
El Hajj, C., Walrand, S., Helou, M., & Yammine, K. (2020). Effect of vitamin D supplementation on inflammatory markers in non-obese Lebanese patients with type 2 diabetes: a randomized controlled trial. Nutrients, 12(7), 2033. https://doi.org/10.3390/nu12072033
Feldkamp, J., Jungheim, K., Schott, M., Jacobs, B., & Roden, M. (2018). Severe vitamin D3 deficiency in the majority of patients with diabetic foot ulcers. Hormone and Metabolic Research, 50(08), 615–619. https://doi.org/10.1055/a-0648-8178
Gombart, A. F., Borregaard, N., & Koeffler, H. P. (2005). Human cathelicidin antimicrobial peptide (CAMP) gene is a direct target of the vitamin D receptor and is strongly up-regulated in myeloid cells by 1, 25-dihydroxyvitamin D3. The FASEB Journal, 19(9), 1067–1077. https://doi.org/10.1096/fj.04-3284com
Greenhagen, R. M., Frykberg, R. G., & Wukich, D. K. (2019). Serum vitamin D and diabetic foot complications. Diabetic Foot & Ankle, 10(1), 1579631. https://doi.org/10.1080/2000625X.2019.1579631
Gupta, B., Dwivedi, A., & Singh, S. K. (2017). Effect of vitamin D supplementation on cytokines expression in patients with diabetic foot infection. Indian Journal of Endocrinology & Metabolism, 21. https://web.s.ebscohost.com/abstract?direct=true&profile=ehost&scope=site&authtype=crawler&jrnl=22308210&AN=122227092&h=hAbCMUYXrfQhQx3oTsvoyEtm1jVWA%2BVi%2Bj5vyQEdEjv8tEzqFxMCyS9nqjdkDU7odAMA6cuTRYJDGFGtfQuJAA%3D%3D&crl=c&resultNs=AdminWebAuth&resultLocal=ErrCrlNotAuth&crlhashurl=login.aspx%3Fdirect%3Dtrue%26profile%3Dehost%26scope%3Dsite%26authtype%3Dcrawler%26jrnl%3D22308210%26AN%3D122227092
Halschou-Jensen, P. M., Sauer, J., Bouchelouche, P., Fabrin, J., Brorson, S., & Ohrt-Nissen, S. (2023). Improved healing of diabetic foot ulcers after high-dose vitamin D: a randomized double-blinded clinical trial. The International Journal of Lower Extremity Wounds, 22(3), 466–474. https://doi.org/10.1177/15347346211020268
Hewison, M. (2011). Vitamin D and innate and adaptive immunity. Vitamins & Hormones, 86, 23–62. https://doi.org/10.1016/B978-0-12-386960-9.00002-2
Ismailova, A., & White, J. H. (2022). Vitamin D, infections and immunity. Reviews in Endocrine and Metabolic Disorders, 1–13. https://doi.org/10.1007/s11154-021-09679-5
Kamble, A., & Swarnkar, M. (2019). A study of the prevalence and severity of vitamin D deficiency in patient with diabetic foot and its association with vascular calcification and effect on healing. International Surgery Journal, 6(5), 1654–1658. https://doi.org/10.18203/2349-2902.isj20191886
Karonova, T., Stepanova, A., Bystrova, A., & Jude, E. B. (2020). High-dose vitamin D supplementation improves microcirculation and reduces inflammation in diabetic neuropathy patients. Nutrients, 12(9), 2518. https://doi.org/10.3390/nu12092518
Khan, M. A. B., Hashim, M. J., King, J. K., Govender, R. D., Mustafa, H., & Al Kaabi, J. (2020). Epidemiology of type 2 diabetes--global burden of disease and forecasted trends. Journal of Epidemiology and Global Health, 10(1), 107. https://doi.org/10.2991/jegh.k.191028.001
Kinesya, E., Santoso, D., Arya, N. G., Cintya, E. P., Ambarini, P. S., Kinesya, B., Kartjito, M. S., & Mannagalli, Y. (2023). Vitamin D as adjuvant therapy for diabetic foot ulcers: Systematic review and meta-analysis approach. Clinical Nutrition ESPEN. https://doi.org/10.1016/j.clnesp.2023.01.011
Kurian, S. J., Miraj, S. S., Benson, R., Munisamy, M., Saravu, K., Rodrigues, G. S., & Rao, M. (2021). Vitamin D supplementation in diabetic foot ulcers: a current perspective. Current Diabetes Reviews, 17(4), 512–521. https://doi.org/10.2174/1573399816999201012195735
L Bishop, E., Ismailova, A., Dimeloe, S., Hewison, M., & White, J. H. (2021). Vitamin D and immune regulation: antibacterial, antiviral, anti-inflammatory. JBMR Plus, 5(1), e10405. https://doi.org/10.1002/jbm4.10405
Lennarz, W. J., & Lane, M. D. (2013). Encyclopedia of biological chemistry. Academic Press.
Lin, J., Mo, X., Yang, Y., Tang, C., & Chen, J. (2023). Association between vitamin D deficiency and diabetic foot ulcer wound in diabetic subjects: A meta-analysis. International Wound Journal, 20(1), 55–62. https://doi.org/10.1111/iwj.13836
Macido, A. (2018). Diabetic foot ulcers and vitamin D status: a literature review. SAGE Open Nursing, 4, 2377960818789027. https://doi.org/10.1177/2377960818789027
Marcinowska-Suchowierska, E., Kupisz-UrbaÅ„ska, M., Åukaszkiewicz, J., & PÅ‚udowski PaweÅ‚and Jones, G. (2018). Vitamin D toxicity--a clinical perspective. Frontiers in Endocrinology, 9, 550. https://doi.org/10.3389/fendo.2018.00550
Mariadoss, A. V. A., Sivakumar, A. S., Lee, C.-H., & Kim, S. J. (2022). Diabetes mellitus and diabetic foot ulcer: Etiology, biochemical and molecular based treatment strategies via gene and nanotherapy. Biomedicine & Pharmacotherapy, 151, 113134. https://doi.org/10.1016/j.biopha.2022.113134
Martens, P.-J., Gysemans, C., Verstuyf, A., & Mathieu, C. (2020). Vitamin D’s effect on immune function. Nutrients, 12(5), 1248. https://doi.org/10.3390/nu12051248
Mousa, A., Naderpoor, N., Teede, H., Scragg, R., & de Courten, B. (2018). Vitamin D supplementation for improvement of chronic low-grade inflammation in patients with type 2 diabetes: a systematic review and meta-analysis of randomized controlled trials. Nutrition Reviews, 76(5), 380–394. https://doi.org/10.1093/nutrit/nux077
Mozaffari-Khosravi, H., Haratian-Arab, M., Tavakkoli, H. M., & Nadjarzadeh, A. (2016). Comparative effect of two different doses of vitamin D on diabetic foot ulcer and inflammatory indices among the type 2 diabetic patients: a randomized clinical trial. Iranian Journal of Diabetes and Obesity, 8(4), 164–171. https://www.researchgate.net/profile/Mohsen-Haratian/publication/356442835_Comparative_Effect_of_Two_Different_Doses_of_Vitamin_D_on_Diabetic_Foot_Ulcer_and_Inflammatory_Indices_among_the_Type_2_Diabetic_Patients_a_Randomized_Clinical_Trial/links/619bfaa3d7d1af224b196a2c/Comparative-Effect-of-Two-Different-Doses-of-Vitamin-D-on-Diabetic-Foot-Ulcer-and-Inflammatory-Indices-among-the-Type-2-Diabetic-Patients-a-Randomized-Clinical-Trial.pdf
Putz, Z., Tordai, D., Hajdú, N., Vági, O. E., Kempler, M., Békeffy, M., Körei, A. E., Istenes, I., Horváth, V., Stoian, A. P., & others. (2022). Vitamin D in the prevention and treatment of diabetic neuropathy. Clinical Therapeutics, 44(5), 813–823. https://doi.org/10.1016/j.clinthera.2022.03.012
Ramasamy, I. (2020). Vitamin D metabolism and guidelines for vitamin D supplementation. The Clinical Biochemist Reviews, 41(3), 103. https://doi.org/10.33176/AACB-20-00006
Razzaghi, R., Pourbagheri, H., Momen-Heravi, M., Bahmani, F., Shadi, J., Soleimani, Z., & Asemi, Z. (2017). The effects of vitamin D supplementation on wound healing and metabolic status in patients with diabetic foot ulcer: a randomized, double-blind, placebo-controlled trial. Journal of Diabetes and Its Complications, 31(4), 766–772. https://doi.org/10.1016/j.jdiacomp.2016.06.017
Schauber, J., & Gallo, R. L. (2008). The vitamin D pathway: a new target for control of the skin’s immune response? Experimental Dermatology, 17(8), 633–639. https://doi.org/10.1111/j.1600-0625.2008.00768.x
Smith, K., & Hewlings, S. (2021). Correlation between vitamin D levels and hard-to-heal wounds: a systematic review. Journal of Wound Care, 30(Sup6), S4--S10. https://doi.org/10.12968/jowc.2021.30.Sup6.S4
Tang, Y., Huang, Y., Luo, L., Xu, M., Deng, D., Fang, Z., Zhao, X., & Chen, M. (2023). Level of 25-hydroxyvitamin D and vitamin D receptor in diabetic foot ulcer and factor associated with diabetic foot ulcers. Diabetology & Metabolic Syndrome, 15(1), 30. https://doi.org/10.1186/s13098-023-01002-3
Tiwari, S., Pratyush, D. D., Gupta, S. K., & Singh, S. K. (2014). Vitamin D deficiency is associated with inflammatory cytokine concentrations in patients with diabetic foot infection. British Journal of Nutrition, 112(12), 1938–1943. https://doi.org/10.1017/S0007114514003018
Urbanovych, A. M., & Shykula, S. I. (2022). Vitamin D and diabetes mellitus. International Journal Of Endocrinology (Ukraine), 18(1), 78–83. https://doi.org/10.22141/2224-0721.18.1.2022.1148
Wang, F., Zhou, L., Zhu, D., & Yang, C. (2022). A retrospective analysis of the relationship between 25-OH-vitamin D and diabetic foot ulcer. Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy, 1347–1355. https://doi.org/10.2147/DMSO.S358170
Wang, Y., Zhu, J., & DeLuca, H. F. (2012). Where is the vitamin D receptor? Archives of Biochemistry and Biophysics, 523(1), 123–133. https://doi.org/10.1016/j.abb.2012.04.001
Wu, C., Qiu, S., Zhu, X., & Li, L. (2017). Vitamin D supplementation and glycemic control in type 2 diabetes patients: A systematic review and meta-analysis. Metabolism, 73, 67–76. https://doi.org/10.1016/j.metabol.2017.05.006
Yamada, S., Shimizu, M., & Yamamoto, K. (2003). Vitamin D receptor. Endocrine Development, 6, 50–68.
Yammine, K., Hayek, F., & Assi, C. (2020). Is there an association between vitamin D and diabetic foot disease? A meta-analysis. Wound Repair and Regeneration, 28(1), 90–96. https://doi.org/10.1111/wrr.12762
Zhang, P., Lu, J., Jing, Y., Tang, S., Zhu, D., & Bi, Y. (2017). Global epidemiology of diabetic foot ulceration: a systematic review and meta-analysis. Annals of Medicine, 49(2), 106–116. https://doi.org/10.1080/07853890.2016.1231932
License
Copyright (c) 2023 Kemas Dahlan, Irfanuddin, Krisna Murti, Akhmadu Muradi
This work is licensed under a Creative Commons Attribution 4.0 International License.
Authors who publish with Jurnal Penelitian Pendidikan IPA, agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution 4.0 International License (CC-BY License). This license allows authors to use all articles, data sets, graphics, and appendices in data mining applications, search engines, web sites, blogs, and other platforms by providing an appropriate reference. The journal allows the author(s) to hold the copyright without restrictions and will retain publishing rights without restrictions.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in Jurnal Penelitian Pendidikan IPA.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
