Vol. 10 No. 6 (2024): June
Open Access
Peer Reviewed

Ascorbic Acid Injection Efficacy to Increase Skin Collagen

Authors

Eny Anggraini , Putu Ayu Asri Damayanti

DOI:

10.29303/jppipa.v10i6.5282

Published:

2024-06-30

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Abstract

The aging process can be delayed by antioxidant supplement such as ascorbic acid. It is useful for reducing oxidative stress, inflammation, and cellular aging so that older people will be fitter and happier. The methodological approach used in this study is Literature Review (LR). This literature review will investigate the effect of ascorbic acid on inflammaging. Google Scholar, Researchgate, and Mendeley were used as the search engine. The keywords were ascorbic acid & skin collagen. The effect of ascorbic acid on geriatric beta-endorphin were analyzed from 14 articles. Body homeostasis, organ systems, and other changes will reduce the functional capacity in the skin collagen. To delay the   physiological process of aging, ascorbic acid potential to improve the skin collagen. The skin collagen can be improved by the effect of ascorbic acid for a better quality of aging process

Keywords:

Anti-aging Ascorbic acid Skin collagen

References

Alexander, M. S., Wilkes, J. G., Schroeder, S. R., Buettner, G. R., Wagner, B. A., Du, J., Gibson-Corley, K., O’Leary, B. R., Spitz, D. R., Buatti, J. M., Berg, D. J., Bodeker, K. L., Vollstedt, S., Brown, H. A., Allen, B. G., & Cullen, J. J. (2018). Pharmacologic ascorbate reduces radiation-induced normal tissue toxicity and enhances tumor radiosensitization in pancreatic cancer. Cancer Research, 78(24), 6838–6851. https://doi.org/10.1158/0008-5472.CAN-18-1680

Aust, M. C., Knobloch, K., Reimers, K., Redeker, J., Ipaktchi, R., Altintas, M. A., Gohritz, A., Schwaiger, N., & Vogt, P. M. (2010). Percutaneous collagen induction therapy: An alternative treatment for burn scars. Burns, 36(6), 836–843. https://doi.org/10.1016/j.burns.2009.11.014

Bacakova, M., Musilkova, J., Riedel, T., Stranska, D., Brynda, E., Zaloudkova, M., & Bacakova, L. (2016). The potential applications of fibrin-coated electrospun polylactide nanofibers in skin tissue engineering. International Journal of Nanomedicine, 11, 771–789. https://doi.org/10.2147/IJN.S99317

Bánvölgyi, A., Lorincz, K., Kiss, N., Avci, P., Fésus, L., Szipocs, R., Krenács, T., Gyöngyösi, N., Wikonkál, N., Kárpáti, S., & Németh, K. (2020). Efficiency of long-term high-dose intravenous ascorbic acid therapy in locally advanced basal cell carcinoma - A pilot study. Postepy Dermatologii i Alergologii, 37(4), 548–558. https://doi.org/10.5114/ada.2019.83027

Boo, Y. C. (2022). Ascorbic Acid (Vitamin C) as a Cosmeceutical to Increase Dermal Collagen for Skin Antiaging Purposes: Emerging Combination Therapies. Antioxidants, 11(9). https://doi.org/10.3390/antiox11091663

Casabona, G., & Marchese, P. (2017). Calcium Hydroxylapatite Combined with Microneedling and Ascorbic Acid is Effective for Treating Stretch Marks. Plastic and Reconstructive Surgery - Global Open, 5(9). https://doi.org/10.1097/GOX.0000000000001474

Dȩbska-Szmich, S., & Potemski, P. (2021). Vitamin C and cancer risk and treatment. Postepy Higieny i Medycyny Doswiadczalnej, 75(1), 987–1004. https://doi.org/10.2478/ahem-2021-0031

Dunn, J. A., Thorpe, S. R., Baynes, J. W., McCance, D. R., Lyons, T. J., & Baynes, J. W. (1991). Age-Dependent Accumulation of nє-(Carboxymethyl)Lysine and nє (Carboxymethyl)Hydroxylysine in Human Skin Collagen. Biochemistry, 30(5), 1205–1210. https://doi.org/10.1021/bi00219a007

Eggersdorfer, M. (2020). What is the optimal intake of vitamin C? Proceedings of the Nutrition Society, 79(OCE2). https://doi.org/10.1017/s0029665120005716

Elhabak, M., Ibrahim, S., & Abouelatta, S. M. (2021). Topical delivery of l-ascorbic acid spanlastics for stability enhancement and treatment of UVB induced damaged skin. Drug Delivery, 28(1), 445–453. https://doi.org/10.1080/10717544.2021.1886377

Franceschi, C., Garagnani, P., Parini, P., Giuliani, C., & Santoro, A. (2018). Inflammaging: a new immune–metabolic viewpoint for age-related diseases. Nature Reviews Endocrinology, 14(10), 576–590. https://doi.org/10.1038/s41574-018-0059-4

Fulop, T., Larbi, A., Pawelec, G., Khalil, A., Cohen, A. A., Hirokawa, K., Witkowski, J. M., & Franceschi, C. (2023). Immunology of Aging: the Birth of Inflammaging. Clinical Reviews in Allergy and Immunology, 64(2), 109–122. https://doi.org/10.1007/s12016-021-08899-6

Gref, R., Deloménie, C., Maksimenko, A., Gouadon, E., Percoco, G., Lati, E., Desmaële, D., Zouhiri, F., & Couvreur, P. (2020). Vitamin C–squalene bioconjugate promotes epidermal thickening and collagen production in human skin. Scientific Reports, 10(1). https://doi.org/10.1038/s41598-020-72704-1

Gross, J., & Schmitt, F. O. (1948). The structure of human skin collagen as studied with the electron microscope. The Journal of Experimental Medicine, 88(5), 555–568. https://doi.org/10.1084/jem.88.5.555

Hartono, A. (2022). Statistik Penduduk Lanjut Usia 2022. Badan Pusat Statistik. Retrieved from www.freepik.com

Işin, S., Yazihan, N., Kesikli, B., Biriken, D., Akdaş, S., Topal Celikkan, F., Bakirarar, B., & Aribal-Ayral, P. (2023). Effect of ascorbic acid on collagen and some inflammatory mediators in rats. Ankara Üniversitesi Veteriner Fakültesi Dergisi, 70(3), 303–308. https://doi.org/10.33988/auvfd.1019201

Jones, K. (2020). Which countries have the oldest populations in the world? World Economic Forum. Retrieved from https://www.weforum.org/agenda/2020/02/ageing-global-population

Kim, J. A., Chung, J. H., Moon, S. E., Youn, S. H., Kwon, O. S., & Eun, H. C. (1996). The effect of ascorbic acid, TGF-β, and IFN-γ on collagen synthesis in three-dimensional culture of normal human skin fibroblast. Korean Journal of Dermatology, 34(4), 608–615. Retrieved from https://pesquisa.bvsalud.org/portal/resource/pt/wpr-171091

Lee, J. E., & Boo, Y. C. (2022). Combination of Glycinamide and Ascorbic Acid Synergistically Promotes Collagen Production and Wound Healing in Human Dermal Fibroblasts. Biomedicines, 10(5). https://doi.org/10.3390/biomedicines10051029

Maekawa, T., Miyake, T., Tani, M., & Uemoto, S. (2022). Diverse antitumor effects of ascorbic acid on cancer cells and the tumor microenvironment. Frontiers in Oncology, 12. https://doi.org/10.3389/fonc.2022.981547

Miyata, T., Wada, Y., Cai, Z., Iida, Y., Horie, K., Yasuda, Y., Maeda, K., Kurokawa, K., & Van Ypersele De Strihou, C. (1997). Implication of an increased oxidative stress in the formation of advanced glycation end products in patients with end-stage renal failure. Kidney International, 51(4), 1170–1181. https://doi.org/10.1038/ki.1997.160

Neves, J., & Sousa-Victor, P. (2020). Regulation of inflammation as an anti-aging intervention. FEBS Journal, 287(1), 43–52. https://doi.org/10.1111/febs.15061

Papaccio, F., D’arino, A., Caputo, S., & Bellei, B. (2022). Focus on the Contribution of Oxidative Stress in Skin Aging. Antioxidants, 11(6). https://doi.org/10.3390/antiox11061121

Prakoeswa, C. R. S., Effendy, Z. F., Herwanto, N., Ervianty, E., & Rantam, F. A. (2021). Efficacy of topical application of a mixture of amniotic membrane stem cell metabolic products and vitamin C after microneedling treatment in patients with photoaging. Journal of Pakistan Association of Dermatologists, 30(3), 485–489. Retrieved from https://jpad.com.pk/index.php/jpad/article/view/1493

Pullar, J. M., Carr, A. C., & Vissers, M. C. M. (2017). The roles of vitamin C in skin health. Nutrients, 9(8). https://doi.org/10.3390/nu9080866

Puścion-Jakubik, A., Markiewicz-żukowska, R., Naliwajko, S. K., Gromkowska-Kępka, K. J., Moskwa, J., Grabia, M., Mielech, A., Bielecka, J., Karpińska, E., Mielcarek, K., Nowakowski, P., & Socha, K. (2021). Intake of antioxidant vitamins and minerals in relation to body composition, skin hydration and lubrication in young women. Antioxidants, 10(7). https://doi.org/10.3390/antiox10071110

Ryu, T. K., Lee, H., Yon, D. K., Nam, D. Y., Lee, S. Y., Shin, B. H., Choi, G. W., Jeon, D. S., Oh, B. B., Kim, J. H., Yoon, Y., Kim, H. J., Duteil, L., Bruno-Bonnet, C., Heo, C. Y., & Kang, S. M. (2022). The antiaging effects of a product containing collagen and ascorbic acid: In vitro, ex vivo, and pre-post intervention clinical trial. PLoS ONE, 17(12). https://doi.org/10.1371/journal.pone.0277188

Siddeeg, S. M., Alsaiari, N. S., Tahoon, M. A., & Rebah, F. B. (2020). The application of nanomaterials as electrode modifiers for the electrochemical detection of ascorbic acid: Review. International Journal of Electrochemical Science, 15. https://doi.org/10.20964/2020.04.13

Valdés, F. (2006). Vitamina C. Actas Dermo-Sifiliograficas, 97(9), 557–568. https://doi.org/10.1016/S0001-7310(06)73466-4

Yin, X., Chen, K., Cheng, H., Chen, X., Feng, S., Song, Y., & Liang, L. (2022). Chemical Stability of Ascorbic Acid Integrated into Commercial Products: A Review on Bioactivity and Delivery Technology. Antioxidants, 11(1). https://doi.org/10.3390/antiox11010153

Yusharyahya, S. N. (2021). Mekanisme Penuaan Kulit sebagai Dasar Pencegahan dan Pengobatan Kulit Menua. EJournal Kedokteran Indonesia, 9(2), 150. https://doi.org/10.23886/ejki.9.49.150

Author Biographies

Eny Anggraini, Udayana University

Author Origin : Indonesia

Putu Ayu Asri Damayanti, Pathology Department, Medical Faculty, Udayana University, 80234, Denpasar, Indonesia

Author Origin : Indonesia

Pathology Department, Medical Faculty, Udayana University, 80234, Denpasar, Indonesia

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How to Cite

Anggraini, E., & Damayanti, P. A. A. (2024). Ascorbic Acid Injection Efficacy to Increase Skin Collagen. Jurnal Penelitian Pendidikan IPA, 10(6), 3449–3454. https://doi.org/10.29303/jppipa.v10i6.5282