Resistance To Antiretroviral Therapy In People With HIV
DOI:
10.29303/jppipa.v9i9.5283Published:
2023-09-25Downloads
Abstract
Human Immunodeficiency Virus (HIV) is a virus that damages the immune system, and has RNA genetic material which is converted by the reverse transcriptase enzyme into DNA. This research aims to determine the existence of resistance by identifying mutations related to drug resistance in HIV-1, especially in the genes encoding the PR and RT enzymes which are the targets of ARVs. This research uses the observational method. Research data analysis was carried out in the form of descriptive data analysis of the output of each formula based on the results of HIV measurements. This study contains a series of reviews that focus on the topic and incidence and possibility of HIV drug resistance (ART) in PLHIV/PLWHA. The main and important thing in detecting the possibility of resistance to ARV therapy is by examining the genotype and phenotype. Standardization between laboratories for drug resistance studies through the use of various methods, especially to identify mixed bases that cause estimated resistance mutations. Additionally, sequencing of protease, RT, and/or integrase is used to identify the clinical significance of DRM. There are two genetic mechanisms of NRTI resistance, namely: (1) discriminative mutations that activate RT to differentiate between the dideoxy-NRTI chain terminator and the cell's own dNTP; and (2) unblocking mutations that facilitate phosphorylytic excision of NRTI-triphosphate from viral DNA. Blocking mutations are also referred to as thymidine analogue mutations (TAMs). Â Â ARV resistance can be detected by examining the virus genotype which aims to determine the occurrence of mutations in one of the virus codons compared to ARV-sensitive wild type HIV-1 and by in vitro phenotyping, where this method takes quite a long time and is usually focused on finding a regimen new drug
Keywords:
ARV CD4 HIV INST NNRTI NRTI Viral loadReferences
Abram, M. E., Ferris, A. L., Shao, W., Alvord, W. G., & Hughes, S. H. (2010). Nature, position, and frequency of mutations made in a single cycle of HIV-1 replication. Journal of virology, 84(19), 9864-9878. https://doi.org/10.1128/jvi.00915-10
Allabidi, A. A. (2014). Comparison Between Flow Cytometry and Bead Method in Counting Cd4 and Cd8 T Lymphocytes in Mouse Spleen Cells Suspension. https://corescholar.libraries.wright.edu/cgi/viewcontent.cgi?article=2529&context=etd_all
Bennett, D. E., Camacho, R. J., Otelea, D., Kuritzkes, D. R., Fleury, H., Kiuchi, M., & Shafer, R. W. (2009). Drug resistance mutations for surveillance of transmitted HIV-1 drug-resistance: 2009 update. PloS one, 4(3), e4724. https://doi.org/10.1371/journal.pone.0004724
Bonner, K., Mezochow, A., Roberts, T., Ford, N., & Cohn, J. (2013). Viral load monitoring as a tool to reinforce adherence: a systematic review. JAIDS Journal of Acquired Immune Deficiency Syndromes, 64(1), 74-78. 10.1097/QAI.0b013e31829f05ac
Bonura, F., Tramuto, F., Vitale, F., Perna, A. M., Viviano, E., & Romano, N. (2010). Transmission of drug-resistant HIV type 1 strains in HAART-naive patients: a 5-year retrospective study in Sicily, Italy. AIDS research and human retroviruses, 26(9), 961-965. https://doi.org/10.1089/aid.2009.0250
Brown, L. K., & Lourie, K. J. (2000). Children and adolescents living with HIV and AIDS: A review. The Journal of Child Psychology and Psychiatry and Allied Disciplines, 41(1), 81-96. https://doi.org/10.1016/j.carbpol.2014.08.068
Charest, H., Doualla-Bell, F., Cantin, R., Murphy, D. G., Lemieux, L., Brenner, B., & Tremblay, C. (2014). A significant reduction in the frequency of HIV-1 drug resistance in Quebec from 2001 to 2011 is associated with a decrease in the monitored viral load. PloS one, 9(10), e109420. https://doi.org/10.1371/journal.pone.0109420
Clutter, D. S., Jordan, M. R., Bertagnolio, S., & Shafer, R. W. (2016). HIV-1 drug resistance and resistance testing. Infection, Genetics and Evolution, 46, 292-307. https://doi.org/10.1016/j.meegid.2016.08.031
Daskalopoulou, M., Rodger, A., Phillips, A. N., Sherr, L., Speakman, A., Collins, S., & Lampe, F. C. (2014). Recreational drug use, polydrug use, and sexual behaviour in HIV-diagnosed men who have sex with men in the UK: results from the cross-sectional ASTRA study. The lancet HIV, 1(1), e22-e31. https://doi.org/10.1016/S2352-3018(14)70001-3
Frost, F. A., & Kumar, M. (2000). INTSERVQUAL–an internal adaptation of the GAP model in a large service organisation. Journal of services marketing, 14(5), 358-377. https://doi.org/10.1108/08876040010340991
Gonzalez-Serna, A., Min, J. E., Woods, C., Chan, D., Lima, V. D., Montaner, J. S. G., ... & Swenson, L. C. (2014). Performance of HIV-1 drug resistance testing at low-level viremia and its ability to predict future virologic outcomes and viral evolution in treatment-naive individuals. Clinical infectious diseases, 58(8), 1165-1173. https://doi.org/10.1093/cid/ciu019
Gupta, R. K., Hill, A., Sawyer, A. W., Cozzi-Lepri, A., von Wyl, V., Yerly, S.. & Pillay, D. (2009). Virological monitoring and resistance to first-line highly active antiretroviral therapy in adults infected with HIV-1 treated under WHO guidelines: a systematic review and meta-analysis. The Lancet infectious diseases, 9(7), 409-417. https://doi.org/10.1016/S1473-3099(09)70136-7
Gustyawan, A., Wuryaningsih, E. W., & Kurniawan, D. E. (2022). Impact of Non-Governmental-Based Supporting Group toward Resilience Level among People with HIV AIDS in Indonesia. 2(4). https://doi.org/10.53713/nhs.v2i2.120
Hutapea, H. (2018). Gambaran kasus mutasi terkait resistensi antiretroviral pada orang dengan HIV-AIDS (ODHA) di tiga Kabupaten/Kota di Provinsi Papua. Buletin Penelitian Kesehatan, 46(3), 199-206. https://doi.org/10.22435/bpk.v46i3.902
Kapila, A., Chaudhary, S., Sharma, R. B., Vashist, H., Sisodia, S. S., & Gupta, A. (2016). A review on: Hiv aids. Indian Journal of Pharmaceutical and Biological Research, 4(3), 69-73. https://www.researchgate.net/profile/Ram-Babu-Sharma/publication/329769510_A_REVIEW_ON_HIV_AIDS/links/646079daf43b8a29ba4c14f3/A-REVIEW-ON-HIV-AIDS.pdf?_sg%5B0%5D=started_experiment_milestone&origin=journalDetail&_rtd=e30%3D
Keele, B. F., Giorgi, E. E., Salazar-Gonzalez, J. F., Decker, J. M., Pham, K. T., Salazar, M. G., ... & Shaw, G. M. (2008). Identification and characterization of transmitted and early founder virus envelopes in primary HIV-1 infection. Proceedings of the National Academy of Sciences, 105(21), 7552-7557. https://doi.org/10.1073/pnas.0802203105
Kiwanuka, N., Laeyendecker, O., Quinn, T. C., Wawer, M. J., Shepherd, J., Robb, M., & Gray, R. H. (2009). HIV-1 subtypes and differences in heterosexual HIV transmission among HIV-discordant couples in Rakai, Uganda. AIDS (London, England), 23(18), 2479. https://doi.org/10.1097%2FQAD.0b013e328330cc08
Koenig, S. P., Dorvil, N., Dévieux, J. G., Hedt-Gauthier, B. L., Riviere, C., Faustin, M., ... & Pape, J. W. (2017). Same-day HIV testing with initiation of antiretroviral therapy versus standard care for persons living with HIV: a randomized unblinded trial. PLoS medicine, 14(7), e1002357. https://doi.org/10.1371/journal.pmed.1002357
Kridaningsih, T. N., Widiyanti, M., Adiningsih, S., Hutapea, H. M. L., Fitriana, E., & Natalia, E. I. (2021). Profile of HIV/AIDS Patients Coinfected with Tuberculosis in Bumi Wonorejo Health Centre and Santo Rafael Clinic Nabire, Papua. Jurnal Kedokteran Brawijaya, 31(4), 247-252. https://doi.org/10.21776/ub.jkb.2021.031.04.10
Li, H. M., Peng, R. R., Li, J., Yin, Y. P., Wang, B., Cohen, M. S., & Chen, X. S. (2011). HIV incidence among men who have sex with men in China: a meta-analysis of published studies. PloS one, 6(8), e23431. https://doi.org/10.1371/journal.pone.0023431
Mohd Zain, R., Ibrahim, N., Ismail, S., Mat-Rahim, N. A., Suppiah, J., Thayan, R. & Saat, Z. (2016). Drug resistance mutations among virological failure HIV-1 infected patients in Malaysia. Tropical Biomedicine, 33(3), 486-493. https://www.researchgate.net/profile/Jeyanthi-Suppiah/publication/309527141_Drug_resistance_mutations_among_virological_failure_HIV-1_infected_patients_in_Malaysia/links/5823f23a08aeebc4f89896e9/Drug-resistance-mutations-among-virological-failure-HIV-1-infected-patients-in-Malaysia.pdf
Molina, J. M., Yazdanpanah, Y., Saud, A. A., Bettacchi, C., Anania, C. C., DeJesus, E., & Sklar, P. (2021). Islatravir in combination with doravirine for treatment-naive adults with HIV-1 infection receiving initial treatment with islatravir, doravirine, and lamivudine: a phase 2b, randomised, double-blind, dose-ranging trial. The Lancet HIV, 8(6), e324-e333. https://doi.org/10.1016/S2352-3018(21)00021-7
Nakano, K., Yokoyama, K., Shin, S., Uchida, K., Tsuji, K., Tanaka, M., & Watanabe, T. (2022). Exploring new functional aspects of HTLV-1 RNA-binding protein Rex: how does Rex control viral replication?. Viruses, 14(2), 407. https://doi.org/10.3390/v14020407
Ne, E., Palstra, R. J., & Mahmoudi, T. (2018). Transcription: insights from the HIV-1 promoter. International review of cell and molecular biology, 335, 191-243. https://doi.org/10.1016/bs.ircmb.2017.07.011
Perelson, A. S., & Ribeiro, R. M. (2013). Modeling the within-host dynamics of HIV infection. BMC biology, 11, 1-10. https://link.springer.com/article/10.1186/1741-7007-11-96
Raffi, F., Rachlis, A., Stellbrink, H. J., Hardy, W. D., Torti, C., Orkin, C. & Min, S. (2013). Once-daily dolutegravir versus raltegravir in antiretroviral-naive adults with HIV-1 infection: 48 week results from the randomised, double-blind, non-inferiority SPRING-2 study. The Lancet, 381(9868), 735-743. https://doi.org/10.1016/S0140-6736(12)61853-4
Rhee, S. Y., Sankaran, K., Varghese, V., Winters, M. A., Hurt, C. B., Eron, J. J., ... & Shafer, R. W. (2016). HIV-1 protease, reverse transcriptase, and integrase variation. Journal of virology, 90(13), 6058-6070. https://doi.org/10.1128/jvi.00495-16
Sadarang, R. A. I. (2022). Prevalence and factors affecting discrimination towards people living with HIV/AIDS in Indonesia. Journal of Preventive Medicine and Public Health, 55(2), 205. https://doi.org/10.3961%2Fjpmph.21.502
Sayan, M., Gündüz, A., Ersöz, G., İnan, A., Deveci, A., Özgür, G. & Akalın, H. (2016). Integrase strand transfer inhibitors (INSTIs) resistance mutations in HIV-1 infected Turkish patients. HIV clinical trials, 17(3), 109-113. https://doi.org/10.1080/15284336.2016.1153303
Skhosana, L., Steegen, K., Bronze, M., Lukhwareni, A., Letsoalo, E., Papathanasopoulos, M. A. & Stevens, W. S. (2015). High prevalence of the K65R mutation in HIV-1 subtype C infected patients failing tenofovir-based first-line regimens in South Africa. PloS one, 10(2), e0118145. https://doi.org/10.1371/journal.pone.0118145
Stover, J., Bollinger, L., Izazola, J. A., Loures, L., DeLay, P., Ghys, P. D., & Fast Track modeling working Group. (2016). What is required to end the AIDS epidemic as a public health threat by 2030? The cost and impact of the fast-track approach. PloS one, 11(5), e0154893. https://doi.org/10.1371/journal.pone.0154893
Tekin, D., Gokengin, D., Onay, H., Erensoy, S., & Sertoz, R. (2021). Investigation of drug resistance against protease, reverse transcriptase, and integrase inhibitors by nextâ€generation sequencing in HIVâ€positive patients. Journal of Medical Virology, 93(6), 3627-3633. https://doi.org/10.1002/jmv.26582
Theys, N., De Smedt, I., Van Gent, J., Danckaert, T., Wang, T., Hendrick, F. & Van Roozendael, M. (2015). Sulfur dioxide vertical column DOAS retrievals from the Ozone Monitoring Instrument: Global observations and comparison to groundâ€based and satellite data. Journal of Geophysical Research: Atmospheres, 120(6), 2470-2491. https://doi.org/10.1002/2014JD022657
World Health Organization. (2016). Progress report 2016: prevent HIV, test and treat all: WHO support for country impact (No. WHO/HIV/2016.24). World Health Organization. https://iris.who.int/bitstream/handle/10665/251713/whohiv?sequence=1
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