Materials and Osseointegration Processes in Dental Implants: A Systematic Review
DOI:
10.29303/jossed.v7i1.13455Published:
2026-04-30Downloads
Abstract
Tooth loss is a common oral health problem that affects chewing ability, appearance, and quality of life. Dental implants have become the most effective solution to restore both function and aesthetics. The success of dental implants depends on biomaterial composition and the osseointegration process between the implant and the alveolar bone. This study analyzed recent advancements in implant materials, surface modifications, and biological factors influencing osseointegration and long-term stability. A randomized clinical trial compared zirconia and titanium implants, evaluating various surface treatments and the use of nano-hydroxyapatite as a bioactive material to enhance osseointegration. Results showed that titanium and zirconia remain dominant implant materials, with clinical success rates above 90%. Surface treatments such as sandblasting, anodization, and nano-hydroxyapatite coating significantly improved osseointegration. Moreover, the application of Platelet-Rich Plasma (PRP) and Platelet-Rich Fibrin (PRF) accelerated tissue healing. Systemic conditions like diabetes, bone quality, and surgical techniques also affected outcomes. Overall, innovations in biomaterials and surface engineering have enhanced implant stability, aesthetics, and durability, showing great promise in improving clinical success and patients’ quality of life
Keywords:
Dental Implant Implant Surface Treatment OsseointegrationReferences
Acerra, A., Caggiano, M., Chiacchio, A., Scognamiglio, B., & D'Ambrosio, F. (2025). PRF and PRP in Dentistry: An Umbrella Review. Journal of Clinical Medicine, 14(9), 3224. https://doi.org/10.3390/jcm14093224
AlRowis, R., Albelaihi, F., Alquraini, H., Almojel, S., Alsudais, A., & Alaqeely, R. (2025). Factors Affecting Dental Implant Failure: A Retrospective Analysis. Healthcare, 13(12), 1356. https://doi.org/10.3390/healthcare13121356
Arefnia, B., Fakheran, O., Jakse, N., & Payer, M. (2025). Patient-reported outcomes of zirconia dental implants: a systematic review and future directions. Journal of Patient-Reported Outcomes, 9(1), 7.
Arsista, D., & Eriwati, Y. K. (2018). Desain dan fungsi implan kedokteran gigi yang beredar di pasaran (Design and Function of Dental Implants Widely Circulated on the Market). Jurnal Kedokteran Gigi Universitas Padjadjaran, 30(3), 168–174.
Chandra, A., & Gani, A. (2023). Successful dental implant placement in patients with diabetes mellitus. Makassar Dental Journal, 12(1), 129–132.
Cho, Y.-D., Kim, S., & Ku, Y. (2021). Effectiveness of dental implantation with the partial split-flap technique on vertical guided bone regeneration: A retrospective study. Journal of Periodontal & Implant Science, 51(6), 433–443. https://doi.org/10.5051/jpis.2103780189
Firdhaus, F., & Handoko, H. (2023). Desain dan Simulasi Dental Implant Resistens Menggunakan Finite Elemen Analysis. Quantum Teknika: Jurnal Teknik Mesin Terapan, 5(1), 21–25. https://doi.org/10.18196/jqt.v5i1.18831
Goker, F., Mali Rai, P., De Santis, D., Colombo, M., Gornati, L., Savoini, E., Panda, S., & Del Fabbro, M. (2025). Outcomes of Dental Implants in Routine Clinical Practice: A Retrospective Multicenter Study. International Journal of Dentistry, 2025, 9930477. https://doi.org/10.1155/ijod/9930477
Halim, A. K., & Poedjiastoeti, W. (2024). Penatalaksanaan Pemasangan Dental Implant pada Kasus Kehilangan Gigi Posterior Tunggal. Jurnal Kedokteran Gigi Terpadu, 6(1), 39–41.
Hao, C. P., Cao, N. J., Zhu, Y. H., et al. (2021). The osseointegration and stability of dental implants with different surface treatments in animal models: a network meta-analysis. Scientific Reports, 11, 13849. https://doi.org/10.1038/s41598-021-93307-4
Hossain, N., Mobarak, M. H., Al Mahmud, M. Z., Islam, M. A., Rayhan, M. T., Hossain, A., & Chowdhury, M. A. (2023). Recent development of dental implant materials, synthesis process, and failure – A review. Results in Chemistry, 5, 100999. https://doi.org/10.1016/j.rechem.2023.100999
Hu, H., Liu, L., Man, Y., Ye, Z., & You, M. (2025). Clinical and radiologic outcomes of dental implants in cemento-osseous dysplasia: a systematic review and retrospective case series. BMC Oral Health, 25, 1117. https://doi.org/10.1186/s12903-025-06509-x
Juliatri, J., & Anindita, P. S. (2021). Gambaran Kehilangan Gigi pada Mahasiswa Tahap Profesi Dokter Gigi. E-GiGi, 9(2), 362–367.
Karyadi, E., & Roza, M. A. (2021). Pengaruh mengunyah buah apel manalagi terhadap penurunan indeks plak usia 9–12 tahun. JIKG (Jurnal Ilmu Kedokteran Gigi), 3(2).
Kementerian Kesehatan Republik Indonesia. (2023). Kesehatan Gigi dan Mulut di Indonesia. Jakarta: Kementerian Kesehatan Republik Indonesia.
Kurniawati, H., Puri, K. E., & Aziz, A. (2023). Aksi Nyata Sehatkan Gigi Dan Mulut Masyarakat Guna Mewujudkan Indonesia Bebas Karies 2030 di SDN 1 Sandik Lombok Barat. Jurnal Pengabdian Magister Pendidikan IPA, 7(1), 355–357.
Kusuma, B., & Suwandi, T. (2023). Penatalaksanaan implan dengan screw cement retained prosthesis. Jurnal Kedokteran Gigi Terapan (KGT), 5(2), 5–8. https://doi.org/10.25105/jkgt.v5i2.18801
Morena, D., Leitão-Almeida, B., Pereira, M., Resende, R., Fernandes, J. C. H., Fernandes, G. V. O., & Borges, T. (2024). Comparative clinical behavior of zirconia versus titanium dental implants: a systematic review and meta-analysis of randomized controlled trials. Journal of Clinical Medicine, 13(15), 4488.
Muharni, R. (2023). Potential of Nano Hydroxyapatite in Dental Implants: Potensi Hidroksiapatit Nano pada Dental Implan. REM (Rekayasa Energi Manufaktur) Jurnal, 8(2), 87–92.
Prawesthi, E., & Handayani, S. (2023). Pembuatan Mahkota Tiruan All Zirconia Multilayered CAD/CAM Pada Pasien Dengan Dukungan Gigi Implan Tipe Endosseus (Laporan Kasus). Jurnal Ilmiah dan Teknologi Kedokteran Gigi, 19(2), 86–92.
Prawesthi, E., Tarsilah, & Marpaung, L. (2022). Penyebab Kehilangan Gigi Pada Remaja Dan Cara Mengatasinya. Poltekkes Kemenkes Jakarta II.
Puspitasari, G. A., Damayanti, L., & Kusumadewi, A. N. (2022). Pola kehilangan gigi berdasarkan klasifikasi Kennedy serta penyebab utama kehilangan gigi pada rahang atas atau rahang bawah usia dewasa muda. Jurnal Kedokteran Gigi Universitas Padjadjaran, 34(3), 216–225.
Ramadhan, A. A., Arifin, R., Hatta, I., Hamdani, R., & Dewi, N. (2023). Hubungan Pengetahuan Kesehatan Gigi dan Mulut Dengan Kehilangan Gigi di Wilayah Kerja Puskesmas Semangat Dalam. Dentin, 7(3).
Rinda, & Ariesanti, Y. (2023). Faktor-faktor yang mempengaruhi penurunan tulang marginal pada awal pemasangan implan dental. Jurnal Kedokteran Gigi Terapan (JKGT), 5(2), 23–25. https://doi.org/10.25105/jkgt.v5i2.18603
Rivero, R. R., da Silva, C. L., Cabral, D. de C., & Maruf, E. M. A. (2025). Preoperative evaluation and surgical planning for dental implant in a patient with systemic comorbidities: A case report. MedNEXT Journal of Medical and Health Sciences, 6(3). https://doi.org/10.54448/mdnt25303
Rostamzadeh, S., Ghasemirad, M., Gerayeli, M., Abasi, M., Pouresmaeliyan Roumani, M., Ganjehzadeh, S., & Moharrami, A. (2025). Radiographic Evaluation of Implant Stability and Osseointegration in Adult Orthodontic Patients. Galen Medical Journal, 14, e3799. https://doi.org/10.31661/gmj.v14i.3799
Sukaryo, S. G., Nugroho, W. S., Prabowo, Y., Nugraha, A., & Suroto, D. (2023). Synthesis and Ti-N sputtering of Zr-Nb alloys for dental implant material. Journal of Physics: Conference Series, 2556(1), 012024. https://doi.org/10.1088/1742-6596/2556/1/012024
Susanna Halim, F., Muharraran, D., Aulia, D. R., Kartika, D. C., & Selvina, W. (2024). Tinjauan Artikel: Pemasangan Dental Implant Setelah Elevasi Lantai Sinus dengan Teknik Osteotomi. Universitas Prima Indonesia.
Taghizadeh, E., Negargar, S., Noorizadeh, S., Mirmohammadi, S. M. M., & Salmani, Z. (2024). Efficacy of Platelet-Rich Plasma and Platelet-Rich Fibrin in Enhancing Dental Implant Osseointegration. Galen Medical Journal, 13(SP1), e3679.
Takefuji, Y. (2025). Dental implant prevalence and durability: A concise review of factors influencing success and failure. Biomaterials and Biosystems, 100109.
Shrivastava, D., Quadri, S. A., Alshadidi, A. A. F., Saini, R., Dewan, M., Oliveira Fernandes, G. V., & Srivastava, K. C. (2024). Clinical Assessment of the Relationship of Dental Implant Materials (Titanium and Zirconia) and Peri-Implantitis: A Systematic Review. Journal of Maxillofacial and Oral Surgery, 24(4), 1010–1028. https://doi.org/10.1007/s12663-024-02409-9
Wahyuni, L. A., Nurilawaty, V., Widiyastuti, R., & Purnama, T. (2021). Pengetahuan tentang penyebab dan dampak kehilangan gigi terhadap kejadian kehilangan gigi pada lansia. JDHT Journal of Dental Hygiene and Therapy, 2(2), 52–57.
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Copyright (c) 2026 Susanna Halim, Niki Yuchinda, Jessica Angelie, Annisa Rizkia Ginting, Vonny Maria

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